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Protein

CB1 cannabinoid receptor-interacting protein 1

Gene

Cnrip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
CB1 cannabinoid receptor-interacting protein 1
Short name:
CRIP-1
Gene namesi
Name:Cnrip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1917505. Cnrip1.

Subcellular locationi

GO - Cellular componenti

  • myelin sheath Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 164164CB1 cannabinoid receptor-interacting protein 1PRO_0000089362Add
BLAST

Proteomic databases

EPDiQ5M8N0.
MaxQBiQ5M8N0.
PaxDbiQ5M8N0.
PeptideAtlasiQ5M8N0.
PRIDEiQ5M8N0.

PTM databases

iPTMnetiQ5M8N0.
PhosphoSiteiQ5M8N0.

Expressioni

Tissue specificityi

Highly expressed in brain. Also detected in heart, lung, intestine, kidney, testis, spleen, liver and muscle (at protein level).1 Publication

Gene expression databases

BgeeiQ5M8N0.
CleanExiMM_CNRIP1.
ExpressionAtlasiQ5M8N0. baseline and differential.
GenevisibleiQ5M8N0. MM.

Interactioni

Subunit structurei

Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050036.

Structurei

3D structure databases

ProteinModelPortaliQ5M8N0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CNRIP family.Curated

Phylogenomic databases

eggNOGiENOG410IK8D. Eukaryota.
ENOG41123ZA. LUCA.
GeneTreeiENSGT00390000004284.
HOGENOMiHOG000089982.
HOVERGENiHBG056498.
InParanoidiQ5M8N0.
OMAiRQPIQVN.
PhylomeDBiQ5M8N0.
TreeFamiTF332485.

Family and domain databases

InterProiIPR029204. CNRIP1.
[Graphical view]
PfamiPF15043. CNRIP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M8N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDLPGLVRL SIALRIQPND GPVFFKVDGQ RFGQNRTIKL LTGSSYKVEV
60 70 80 90 100
KIKPTTLQVE NISIGGVLVP LELKGKEPDG ERVVYTGIYD TEGVAPTKSG
110 120 130 140 150
ERQPIQITMP FTDIGTFETV WQVKFYNYHK RDHCQWGSPF SVIEYECKPN
160
ETRSLMWVNK ESFL
Length:164
Mass (Da):18,612
Last modified:February 1, 2005 - v1
Checksum:i856D3B0E240ACD8D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti149 – 1491P → H in BAE28498 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148349 mRNA. Translation: BAE28498.1.
AK171947 mRNA. Translation: BAE42741.1.
AL606466 Genomic DNA. Translation: CAI51922.1.
CH466574 Genomic DNA. Translation: EDL40679.1.
CH466574 Genomic DNA. Translation: EDL40680.1.
BC087946 mRNA. Translation: AAH87946.1.
CCDSiCCDS24447.1.
RefSeqiNP_084137.1. NM_029861.2.
UniGeneiMm.425666.

Genome annotation databases

EnsembliENSMUST00000058159; ENSMUSP00000050036; ENSMUSG00000044629.
GeneIDi380686.
KEGGimmu:380686.
UCSCiuc007iby.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148349 mRNA. Translation: BAE28498.1.
AK171947 mRNA. Translation: BAE42741.1.
AL606466 Genomic DNA. Translation: CAI51922.1.
CH466574 Genomic DNA. Translation: EDL40679.1.
CH466574 Genomic DNA. Translation: EDL40680.1.
BC087946 mRNA. Translation: AAH87946.1.
CCDSiCCDS24447.1.
RefSeqiNP_084137.1. NM_029861.2.
UniGeneiMm.425666.

3D structure databases

ProteinModelPortaliQ5M8N0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050036.

PTM databases

iPTMnetiQ5M8N0.
PhosphoSiteiQ5M8N0.

Proteomic databases

EPDiQ5M8N0.
MaxQBiQ5M8N0.
PaxDbiQ5M8N0.
PeptideAtlasiQ5M8N0.
PRIDEiQ5M8N0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058159; ENSMUSP00000050036; ENSMUSG00000044629.
GeneIDi380686.
KEGGimmu:380686.
UCSCiuc007iby.1. mouse.

Organism-specific databases

CTDi25927.
MGIiMGI:1917505. Cnrip1.

Phylogenomic databases

eggNOGiENOG410IK8D. Eukaryota.
ENOG41123ZA. LUCA.
GeneTreeiENSGT00390000004284.
HOGENOMiHOG000089982.
HOVERGENiHBG056498.
InParanoidiQ5M8N0.
OMAiRQPIQVN.
PhylomeDBiQ5M8N0.
TreeFamiTF332485.

Miscellaneous databases

PROiQ5M8N0.
SOURCEiSearch...

Gene expression databases

BgeeiQ5M8N0.
CleanExiMM_CNRIP1.
ExpressionAtlasiQ5M8N0. baseline and differential.
GenevisibleiQ5M8N0. MM.

Family and domain databases

InterProiIPR029204. CNRIP1.
[Graphical view]
PfamiPF15043. CNRIP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a."
    Niehaus J.L., Liu Y., Wallis K.T., Egertova M., Bhartur S.G., Mukhopadhyay S., Shi S., He H., Selley D.E., Howlett A.C., Elphick M.R., Lewis D.L.
    Mol. Pharmacol. 72:1557-1566(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiCNRP1_MOUSE
AccessioniPrimary (citable) accession number: Q5M8N0
Secondary accession number(s): Q3TAC7, Q3UFR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: February 1, 2005
Last modified: July 6, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.