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Protein

CB1 cannabinoid receptor-interacting protein 1

Gene

Cnrip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
CB1 cannabinoid receptor-interacting protein 1
Short name:
CRIP-1
Gene namesi
Name:Cnrip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1917505 Cnrip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000893621 – 164CB1 cannabinoid receptor-interacting protein 1Add BLAST164

Proteomic databases

MaxQBiQ5M8N0
PaxDbiQ5M8N0
PeptideAtlasiQ5M8N0
PRIDEiQ5M8N0

PTM databases

iPTMnetiQ5M8N0
PhosphoSitePlusiQ5M8N0

Expressioni

Tissue specificityi

Highly expressed in brain. Also detected in heart, lung, intestine, kidney, testis, spleen, liver and muscle (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000044629
CleanExiMM_CNRIP1
ExpressionAtlasiQ5M8N0 baseline and differential
GenevisibleiQ5M8N0 MM

Interactioni

Subunit structurei

Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi237596, 2 interactors
IntActiQ5M8N0, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ5M8N0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CNRIP family.Curated

Phylogenomic databases

eggNOGiENOG410IK8D Eukaryota
ENOG41123ZA LUCA
GeneTreeiENSGT00390000004284
HOGENOMiHOG000089982
HOVERGENiHBG056498
InParanoidiQ5M8N0
OMAiRQPIQVN
PhylomeDBiQ5M8N0
TreeFamiTF332485

Family and domain databases

InterProiView protein in InterPro
IPR029204 CNRIP1
PANTHERiPTHR31952 PTHR31952, 1 hit
PfamiView protein in Pfam
PF15043 CNRIP1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5M8N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDLPGLVRL SIALRIQPND GPVFFKVDGQ RFGQNRTIKL LTGSSYKVEV
60 70 80 90 100
KIKPTTLQVE NISIGGVLVP LELKGKEPDG ERVVYTGIYD TEGVAPTKSG
110 120 130 140 150
ERQPIQITMP FTDIGTFETV WQVKFYNYHK RDHCQWGSPF SVIEYECKPN
160
ETRSLMWVNK ESFL
Length:164
Mass (Da):18,612
Last modified:February 1, 2005 - v1
Checksum:i856D3B0E240ACD8D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149P → H in BAE28498 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148349 mRNA Translation: BAE28498.1
AK171947 mRNA Translation: BAE42741.1
AL606466 Genomic DNA Translation: CAI51922.1
CH466574 Genomic DNA Translation: EDL40679.1
CH466574 Genomic DNA Translation: EDL40680.1
BC087946 mRNA Translation: AAH87946.1
CCDSiCCDS24447.1
RefSeqiNP_084137.1, NM_029861.2
UniGeneiMm.425666

Genome annotation databases

EnsembliENSMUST00000058159; ENSMUSP00000050036; ENSMUSG00000044629
GeneIDi380686
KEGGimmu:380686
UCSCiuc007iby.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCNRP1_MOUSE
AccessioniPrimary (citable) accession number: Q5M8N0
Secondary accession number(s): Q3TAC7, Q3UFR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: February 1, 2005
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health