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Q5M8L0 (OTU6B_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
OTU domain-containing protein 6B

EC=3.4.19.12
Gene names
Name:otud6b
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Contains 1 OTU domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294OTU domain-containing protein 6B
PRO_0000076284

Regions

Domain150 – 287138OTU
Region155 – 1617Cys-loop By similarity
Region222 – 23211Variable-loop By similarity
Region270 – 28011His-loop By similarity

Sites

Active site1581 By similarity
Active site1611Nucleophile By similarity
Active site2801 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5M8L0 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 646F5246455D08D6

FASTA29433,367
        10         20         30         40         50         60 
MDEAEGNSEE SGLIKQHRKE KRDLQAKIQS MKNSVPKNDK KRRKQLTEDI AKLEADLDVR 

        70         80         90        100        110        120 
HKEELEAFAQ KQPEPTQVSG ITNGVTSLDL GNEAPVQQPR QSKAQKRREK KAAQEKERDE 

       130        140        150        160        170        180 
RIAEAEIANL SGARHLESQK LARILAEREL QIRQIPSDGH CMYRAIEHQL RERGNDLTVA 

       190        200        210        220        230        240 
NLRSQTADYM QNHAEDFLPF LTNSSTGDMY TQEEFLKYCT DIVNTPAWGG QLELRALSHI 

       250        260        270        280        290 
LKTAIEVIQA ESSPIVIGEE YSSKAITLVY MRHAYGLGEH YNSVELLDTS TENS 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC087978 mRNA. Translation: AAH87978.1.
RefSeqNP_001011269.1. NM_001011269.1.
UniGeneStr.11832.

3D structure databases

ProteinModelPortalQ5M8L0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000031929.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID496720.
KEGGxtr:496720.

Organism-specific databases

CTD51633.
XenbaseXB-GENE-985119. otud6b.

Phylogenomic databases

eggNOGCOG5539.
HOGENOMHOG000192906.
HOVERGENHBG080227.
InParanoidQ5M8L0.

Gene expression databases

BgeeQ5M8L0.

Family and domain databases

InterProIPR003323. OTU.
[Graphical view]
PfamPF02338. OTU. 1 hit.
[Graphical view]
PROSITEPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOTU6B_XENTR
AccessionPrimary (citable) accession number: Q5M8L0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: February 1, 2005
Last modified: November 13, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families