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Protein

OTU domain-containing protein 6B

Gene

otud6b

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei158 – 1581By similarity
Active sitei161 – 1611NucleophileBy similarity
Active sitei280 – 2801By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 6B (EC:3.4.19.12)
Gene namesi
Name:otud6b
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-985119. otud6b.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294OTU domain-containing protein 6BPRO_0000076284Add
BLAST

Expressioni

Gene expression databases

BgeeiQ5M8L0.
ExpressionAtlasiQ5M8L0. baseline.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000031929.

Structurei

3D structure databases

ProteinModelPortaliQ5M8L0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini150 – 287138OTUPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni155 – 1617Cys-loopBy similarity
Regioni222 – 23211Variable-loopBy similarityAdd
BLAST
Regioni270 – 28011His-loopBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 OTU domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5539.
HOGENOMiHOG000192906.
HOVERGENiHBG080227.
InParanoidiQ5M8L0.
KOiK18342.

Family and domain databases

InterProiIPR003323. OTU_dom.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M8L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEAEGNSEE SGLIKQHRKE KRDLQAKIQS MKNSVPKNDK KRRKQLTEDI
60 70 80 90 100
AKLEADLDVR HKEELEAFAQ KQPEPTQVSG ITNGVTSLDL GNEAPVQQPR
110 120 130 140 150
QSKAQKRREK KAAQEKERDE RIAEAEIANL SGARHLESQK LARILAEREL
160 170 180 190 200
QIRQIPSDGH CMYRAIEHQL RERGNDLTVA NLRSQTADYM QNHAEDFLPF
210 220 230 240 250
LTNSSTGDMY TQEEFLKYCT DIVNTPAWGG QLELRALSHI LKTAIEVIQA
260 270 280 290
ESSPIVIGEE YSSKAITLVY MRHAYGLGEH YNSVELLDTS TENS
Length:294
Mass (Da):33,367
Last modified:February 1, 2005 - v1
Checksum:i646F5246455D08D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087978 mRNA. Translation: AAH87978.1.
RefSeqiNP_001011269.1. NM_001011269.1.
UniGeneiStr.11832.

Genome annotation databases

GeneIDi496720.
KEGGixtr:496720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087978 mRNA. Translation: AAH87978.1.
RefSeqiNP_001011269.1. NM_001011269.1.
UniGeneiStr.11832.

3D structure databases

ProteinModelPortaliQ5M8L0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000031929.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi496720.
KEGGixtr:496720.

Organism-specific databases

CTDi51633.
XenbaseiXB-GENE-985119. otud6b.

Phylogenomic databases

eggNOGiCOG5539.
HOGENOMiHOG000192906.
HOVERGENiHBG080227.
InParanoidiQ5M8L0.
KOiK18342.

Gene expression databases

BgeeiQ5M8L0.
ExpressionAtlasiQ5M8L0. baseline.

Family and domain databases

InterProiIPR003323. OTU_dom.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiOTU6B_XENTR
AccessioniPrimary (citable) accession number: Q5M8L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: February 1, 2005
Last modified: June 24, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.