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Protein

Deubiquitinase OTUD6B

Gene

otud6b

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of different cellular processes.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei158By similarity1
Active sitei161NucleophileBy similarity1
Active sitei280By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Protein family/group databases

MEROPSiC85.008

Names & Taxonomyi

Protein namesi
Recommended name:
Deubiquitinase OTUD6BCurated (EC:3.4.19.12By similarity)
Gene namesi
Name:otud6b
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-985119 otud6b

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000762841 – 294Deubiquitinase OTUD6BAdd BLAST294

Proteomic databases

PaxDbiQ5M8L0

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000031929

Structurei

3D structure databases

ProteinModelPortaliQ5M8L0
SMRiQ5M8L0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini150 – 287OTUPROSITE-ProRule annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni155 – 161Cys-loopBy similarity7
Regioni222 – 232Variable-loopBy similarityAdd BLAST11
Regioni270 – 280His-loopBy similarityAdd BLAST11

Phylogenomic databases

eggNOGiKOG2606 Eukaryota
COG5539 LUCA
HOGENOMiHOG000192906
HOVERGENiHBG080227
InParanoidiQ5M8L0
KOiK18342
OrthoDBiEOG091G0VVZ

Family and domain databases

InterProiView protein in InterPro
IPR003323 OTU_dom
IPR038765 Papain_like_cys_pep_sf
PfamiView protein in Pfam
PF02338 OTU, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50802 OTU, 1 hit

Sequencei

Sequence statusi: Complete.

Q5M8L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEAEGNSEE SGLIKQHRKE KRDLQAKIQS MKNSVPKNDK KRRKQLTEDI
60 70 80 90 100
AKLEADLDVR HKEELEAFAQ KQPEPTQVSG ITNGVTSLDL GNEAPVQQPR
110 120 130 140 150
QSKAQKRREK KAAQEKERDE RIAEAEIANL SGARHLESQK LARILAEREL
160 170 180 190 200
QIRQIPSDGH CMYRAIEHQL RERGNDLTVA NLRSQTADYM QNHAEDFLPF
210 220 230 240 250
LTNSSTGDMY TQEEFLKYCT DIVNTPAWGG QLELRALSHI LKTAIEVIQA
260 270 280 290
ESSPIVIGEE YSSKAITLVY MRHAYGLGEH YNSVELLDTS TENS
Length:294
Mass (Da):33,367
Last modified:February 1, 2005 - v1
Checksum:i646F5246455D08D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087978 mRNA Translation: AAH87978.1
RefSeqiNP_001011269.1, NM_001011269.1
UniGeneiStr.11832

Genome annotation databases

GeneIDi496720
KEGGixtr:496720

Similar proteinsi

Entry informationi

Entry nameiOTU6B_XENTR
AccessioniPrimary (citable) accession number: Q5M8L0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: February 1, 2005
Last modified: June 20, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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