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Q5M8L0

- OTU6B_XENTR

UniProt

Q5M8L0 - OTU6B_XENTR

Protein

OTU domain-containing protein 6B

Gene

otud6b

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei158 – 1581By similarity
    Active sitei161 – 1611NucleophileBy similarity
    Active sitei280 – 2801By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    OTU domain-containing protein 6B (EC:3.4.19.12)
    Gene namesi
    Name:otud6b
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-985119. otud6b.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294OTU domain-containing protein 6BPRO_0000076284Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ5M8L0.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000031929.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5M8L0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini150 – 287138OTUPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni155 – 1617Cys-loopBy similarity
    Regioni222 – 23211Variable-loopBy similarityAdd
    BLAST
    Regioni270 – 28011His-loopBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 OTU domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5539.
    HOGENOMiHOG000192906.
    HOVERGENiHBG080227.
    InParanoidiQ5M8L0.
    KOiK18342.

    Family and domain databases

    InterProiIPR003323. OTU.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5M8L0-1 [UniParc]FASTAAdd to Basket

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    MDEAEGNSEE SGLIKQHRKE KRDLQAKIQS MKNSVPKNDK KRRKQLTEDI    50
    AKLEADLDVR HKEELEAFAQ KQPEPTQVSG ITNGVTSLDL GNEAPVQQPR 100
    QSKAQKRREK KAAQEKERDE RIAEAEIANL SGARHLESQK LARILAEREL 150
    QIRQIPSDGH CMYRAIEHQL RERGNDLTVA NLRSQTADYM QNHAEDFLPF 200
    LTNSSTGDMY TQEEFLKYCT DIVNTPAWGG QLELRALSHI LKTAIEVIQA 250
    ESSPIVIGEE YSSKAITLVY MRHAYGLGEH YNSVELLDTS TENS 294
    Length:294
    Mass (Da):33,367
    Last modified:February 1, 2005 - v1
    Checksum:i646F5246455D08D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC087978 mRNA. Translation: AAH87978.1.
    RefSeqiNP_001011269.1. NM_001011269.1.
    UniGeneiStr.11832.

    Genome annotation databases

    GeneIDi496720.
    KEGGixtr:496720.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC087978 mRNA. Translation: AAH87978.1 .
    RefSeqi NP_001011269.1. NM_001011269.1.
    UniGenei Str.11832.

    3D structure databases

    ProteinModelPortali Q5M8L0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000031929.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 496720.
    KEGGi xtr:496720.

    Organism-specific databases

    CTDi 51633.
    Xenbasei XB-GENE-985119. otud6b.

    Phylogenomic databases

    eggNOGi COG5539.
    HOGENOMi HOG000192906.
    HOVERGENi HBG080227.
    InParanoidi Q5M8L0.
    KOi K18342.

    Gene expression databases

    Bgeei Q5M8L0.

    Family and domain databases

    InterProi IPR003323. OTU.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiOTU6B_XENTR
    AccessioniPrimary (citable) accession number: Q5M8L0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3