Q5M8H5 (MOGT2_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-acylglycerol O-acyltransferase 2
EC=2.3.1.22

Alternative name(s):
Acyl-CoA:monoacylglycerol acyltransferase 2
Short name=MGAT2
Monoacylglycerol O-acyltransferase 2

Gene names

Name:

mogat2

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA By similarity.
Catalytic activity	Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
Pathway	Glycerolipid metabolism; triacylglycerol biosynthesis.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the diacylglycerol acyltransferase family.

Ontologies

Keywords
Biological process	Glycerol metabolism Lipid metabolism Lipid synthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Acyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycerol metabolic process Inferred from electronic annotation. Source: UniProtKB-KW lipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2-acylglycerol O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	2-acylglycerol O-acyltransferase 2		PRO_0000249066
Regions
	Transmembrane	24 – 44	21	Helical; Potential
	Transmembrane	104 – 124	21	Helical; Potential
Amino acid modifications
	Glycosylation	206	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5M8H5 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: B970656C15837ED2	FASTA	335	37,897
	10 20 30 40 50 60 MWIHFAPLKI PFSRRLQTGA VLQWAVSFLA MAQCCIALYI LLLFSRYWYL AVLYGVWLYI 70 80 90 100 110 120 DWDTPSKGGR RSNWVRSWTV WKYFAEYFPI KLLCTAPLDP KYNYIMGFHP HGVLVVGAFG 130 140 150 160 170 180 NFCTEGTGFS RLFPGLTPHL LMLPAWFRVP FFREYIMSGS LVSSDRSSAH HLLSQKSGGQ 190 200 210 220 230 240 ALVIAVGGPP EALDAKPGEL TLQLLNRTGF IKMALTHGAH LVPVLSFGEN DLYNQVNNPR 250 260 270 280 290 300 GSLLRATQEK LQKIFGIALP LFHGRGVFQY SWGLLPHRRP IYTVVGSPIH VTKTPCPTRE 310 320 330 QISSLHSLYI AKLRDLFETH KGNYGIPEDR SLVLC

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC088019 mRNA. Translation: AAH88019.1.
RefSeq	NP_001011301.1. NM_001011301.1.
UniGene	Str.27777.
3D structure databases
ProteinModelPortal	Q5M8H5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSXETT00000008697; ENSXETP00000008697; ENSXETG00000004012.
GeneID	496754.
KEGG	xtr:496754.
Organism-specific databases
CTD	496214.
Xenbase	XB-GENE-6040330. mogat2.1.
Phylogenomic databases
eggNOG	veNOG04599.
GeneTree	ENSGT00550000074276.
HOGENOM	HBG561030.
HOVERGEN	HBG065791.
InParanoid	Q5M8H5.
OMA	VENHENN.
OrthoDB	EOG4BP1C4.
Gene expression databases
Bgee	Q5M8H5.
Family and domain databases
InterPro	IPR007130. DAGAT. [Graphical view]
KO	K14457.
PANTHER	PTHR12317. DAGAT. 1 hit.
Pfam	PF03982. DAGAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MOGT2_XENTR

Accession

Primary (citable) accession number: Q5M8H5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	February 1, 2005
Last modified:	November 16, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program