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Protein

Chloride intracellular channel protein 2

Gene

Clic2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiR-RNO-2672351. Stimuli-sensing channels.
R-RNO-5578775. Ion homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride intracellular channel protein 2
Gene namesi
Name:Clic2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1306580. Clic2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52Helical; Note=After insertion into the membraneSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442061 – 245Chloride intracellular channel protein 2Add BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 33In soluble formBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ5M883.
PRIDEiQ5M883.

PTM databases

iPTMnetiQ5M883.
PhosphoSitePlusiQ5M883.

Expressioni

Gene expression databases

BgeeiENSRNOG00000000728.
GenevisibleiQ5M883. RN.

Interactioni

Subunit structurei

Monomer. Interacts with TRAPPC2 and RYR2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000955.

Structurei

3D structure databases

ProteinModelPortaliQ5M883.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 239GST C-terminalAdd BLAST141

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 96Required for insertion into the membraneBy similarityAdd BLAST96

Domaini

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).By similarity

Sequence similaritiesi

Belongs to the chloride channel CLIC family.Curated
Contains 1 GST C-terminal domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1422. Eukaryota.
ENOG410ZRK6. LUCA.
GeneTreeiENSGT00550000074477.
HOGENOMiHOG000231548.
HOVERGENiHBG050994.
InParanoidiQ5M883.
KOiK05022.
OMAiHDGENIG.
OrthoDBiEOG091G0IHT.
PhylomeDBiQ5M883.
TreeFamiTF315438.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR002946. CLIC.
IPR030253. CLIC-2.
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11260:SF133. PTHR11260:SF133. 2 hits.
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01263. INTCLCHANNEL.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00862. O-ClC. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLALNTQA DPEIELFVKA GSDGESIGNC PFCQRLFMIL WLKGVKFNVT
60 70 80 90 100
TIDTARKPEE LKDLAPGTNP PFLIYNKELK TDFIKIEEFL EKTLAPPRYP
110 120 130 140 150
HLSPKYKESF DVGCNLFAKF SAYIKNTQKE ANKNFEKSLL REFKRLDDYL
160 170 180 190 200
NTPLLDEIDP DSTEERTLSR RLFLDGDQLT LADCSLLPKL NIIKVAAKKY
210 220 230 240
RDFDIPAEFS GVWRYLHNAY AREEFAHTCP EDKEIENTYA SVAKQ
Length:245
Mass (Da):28,161
Last modified:February 1, 2005 - v1
Checksum:iDE6379E6FC9C86A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088182 mRNA. Translation: AAH88182.1.
RefSeqiNP_001009651.1. NM_001009651.1.
UniGeneiRn.103254.

Genome annotation databases

EnsembliENSRNOT00000000955; ENSRNOP00000000955; ENSRNOG00000000728.
GeneIDi294141.
KEGGirno:294141.
UCSCiRGD:1306580. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088182 mRNA. Translation: AAH88182.1.
RefSeqiNP_001009651.1. NM_001009651.1.
UniGeneiRn.103254.

3D structure databases

ProteinModelPortaliQ5M883.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000955.

PTM databases

iPTMnetiQ5M883.
PhosphoSitePlusiQ5M883.

Proteomic databases

PaxDbiQ5M883.
PRIDEiQ5M883.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000955; ENSRNOP00000000955; ENSRNOG00000000728.
GeneIDi294141.
KEGGirno:294141.
UCSCiRGD:1306580. rat.

Organism-specific databases

CTDi1193.
RGDi1306580. Clic2.

Phylogenomic databases

eggNOGiKOG1422. Eukaryota.
ENOG410ZRK6. LUCA.
GeneTreeiENSGT00550000074477.
HOGENOMiHOG000231548.
HOVERGENiHBG050994.
InParanoidiQ5M883.
KOiK05022.
OMAiHDGENIG.
OrthoDBiEOG091G0IHT.
PhylomeDBiQ5M883.
TreeFamiTF315438.

Enzyme and pathway databases

ReactomeiR-RNO-2672351. Stimuli-sensing channels.
R-RNO-5578775. Ion homeostasis.

Miscellaneous databases

PROiQ5M883.

Gene expression databases

BgeeiENSRNOG00000000728.
GenevisibleiQ5M883. RN.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR002946. CLIC.
IPR030253. CLIC-2.
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11260:SF133. PTHR11260:SF133. 2 hits.
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01263. INTCLCHANNEL.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00862. O-ClC. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLIC2_RAT
AccessioniPrimary (citable) accession number: Q5M883
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: February 1, 2005
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.