Q5M882 (RPP29_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein subunit p29
EC=3.1.26.5

Gene names

Name:	Pop4
Synonyms:	Rpp29

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P By similarity.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
Subunit structure	Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of a RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and POP5 By similarity.
Subcellular location	Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 1 family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Nucleus
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA cleavage Inferred from electronic annotation. Source: InterPro rRNA processing Inferred from electronic annotation. Source: InterPro tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleolar ribonuclease P complex Inferred from electronic annotation. Source: InterPro ribonuclease MRP complex Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease P activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Ribonuclease P protein subunit p29		PRO_0000128421
Amino acid modifications
	Modified residue	10	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5M882 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 1BC37779DD9B099E	FASTA	221	25,633
	10 20 30 40 50 60 MKAVIYHAFS HKEAKDHDVQ ELGTQRAEAF VRAFLKQSIP HMSQQDCESH LQRKAVILEY 70 80 90 100 110 120 FTRLKPKPRP KKKSKGLSAK QRRELRLFDI KPEQQRYSLF LPLHELWKQY IRDLCNGLKP 130 140 150 160 170 180 DTQPQMIQAK LLKADLHGAV ISVTKSKCPS YVGVTGILLQ ETKHVFKIIT KEDHLKVIPK 190 200 210 220 QNCVFTIEID DFISYIYGSK FQLRASERSA KKFKAKGTID L

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC088183 mRNA. Translation: AAH88183.1.
IPI	IPI00364315.
RefSeq	NP_001009642.1. NM_001009642.1.
UniGene	Rn.3013.
3D structure databases
ProteinModelPortal	Q5M882.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000020474.
Proteomic databases
PaxDb	Q5M882.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000020474; ENSRNOP00000020474; ENSRNOG00000027646.
GeneID	292831.
KEGG	rno:292831.
UCSC	RGD:1305955. rat.
Organism-specific databases
CTD	10775.
RGD	1305955. Pop4.
Phylogenomic databases
eggNOG	NOG255667.
GeneTree	ENSGT00390000010067.
HOGENOM	HOG000007746.
HOVERGEN	HBG002676.
InParanoid	Q5M882.
KO	K03538.
OrthoDB	EOG4TXBT7.
Gene expression databases
Genevestigator	Q5M882.
GermOnline	ENSRNOG00000027646. Rattus norvegicus.
Family and domain databases
Gene3D	2.30.30.210. 1 hit.
InterPro	IPR002730. RNase_P/MRP_p29. IPR016848. RNase_P/MRP_p29-subunit. IPR023534. Rof/RNase_P-like. [Graphical view]
Pfam	PF01868. UPF0086. 1 hit. [Graphical view]
PIRSF	PIRSF027081. RNase_P/MRP_p29_subunit. 1 hit.
SMART	SM00538. POP4. 1 hit. [Graphical view]
SUPFAM	SSF101744. RNase_P_Rpp29. 1 hit.
ProtoNet	Search...
Other
NextBio	634875.

Entry information

Entry name

RPP29_RAT

Accession

Primary (citable) accession number: Q5M882

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	February 1, 2005
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program