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Protein

SPRY domain-containing SOCS box protein 2

Gene

Spsb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
SPRY domain-containing SOCS box protein 2
Short name:
SSB-2
Gene namesi
Name:Spsb2
Synonyms:Ssb2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 4, Chromosome 9

Organism-specific databases

RGDi1310854. Spsb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264SPRY domain-containing SOCS box protein 2PRO_0000238476Add
BLAST

Proteomic databases

PaxDbiQ5M877.

Expressioni

Gene expression databases

GenevisibleiQ5M877. RN.

Interactioni

Subunit structurei

Component of the probable ECS(SPSB2) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, elongin BC complex and WSB1. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Interacts with PAWR and MET (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064453.

Structurei

3D structure databases

ProteinModelPortaliQ5M877.
SMRiQ5M877. Positions 12-228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 221196B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST
Domaini222 – 26443SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Belongs to the SPSB family.Curated
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3953. Eukaryota.
ENOG410XQC1. LUCA.
GeneTreeiENSGT00390000009402.
HOGENOMiHOG000230524.
HOVERGENiHBG055793.
InParanoidiQ5M877.
KOiK10344.
OMAiWPREQRG.
OrthoDBiEOG72C513.
PhylomeDBiQ5M877.
TreeFamiTF312822.

Family and domain databases

InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR001496. SOCS_box.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF07525. SOCS_box. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M877-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQTALARGS SSTPSSHALY SDLSPPEGLE ELLSAPPPDL GAQRHHGWNP
60 70 80 90 100
KDCSENIDVK EGGLCFERRP VAQSTDGVRG KRGYSRGLHA WEISWPLEQR
110 120 130 140 150
GTHAVVGVAT ALAPLQADHY AALLGSNSES WGWDIGRGKL YHQSKGLEAP
160 170 180 190 200
QYPAGPQGEQ LVVPERLLVV LDMEEGTLGY SIGGTYLGPA FRGLKGRTLY
210 220 230 240 250
PSVSAVWGQC QVRIRYLGER RAEEPQSLLH LSRLCVRHAL GDTRLGQISS
260
LPLPPAMKRY LLYK
Length:264
Mass (Da):28,797
Last modified:February 1, 2005 - v1
Checksum:i2C3578010FE81C02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088189 mRNA. Translation: AAH88189.1.
RefSeqiNP_001009660.1. NM_001009660.1.
XP_003750703.1. XM_003750655.3.
XP_006237398.1. XM_006237336.2.
XP_006237399.1. XM_006237337.2.
XP_006244687.1. XM_006244625.2.
XP_006244688.1. XM_006244626.2.
UniGeneiRn.162769.

Genome annotation databases

EnsembliENSRNOT00000020493; ENSRNOP00000020493; ENSRNOG00000015125.
ENSRNOT00000072086; ENSRNOP00000064453; ENSRNOG00000047113.
GeneIDi100911548.
297592.
KEGGirno:100911548.
rno:297592.
UCSCiRGD:1310854. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088189 mRNA. Translation: AAH88189.1.
RefSeqiNP_001009660.1. NM_001009660.1.
XP_003750703.1. XM_003750655.3.
XP_006237398.1. XM_006237336.2.
XP_006237399.1. XM_006237337.2.
XP_006244687.1. XM_006244625.2.
XP_006244688.1. XM_006244626.2.
UniGeneiRn.162769.

3D structure databases

ProteinModelPortaliQ5M877.
SMRiQ5M877. Positions 12-228.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064453.

Proteomic databases

PaxDbiQ5M877.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020493; ENSRNOP00000020493; ENSRNOG00000015125.
ENSRNOT00000072086; ENSRNOP00000064453; ENSRNOG00000047113.
GeneIDi100911548.
297592.
KEGGirno:100911548.
rno:297592.
UCSCiRGD:1310854. rat.

Organism-specific databases

CTDi84727.
RGDi1310854. Spsb2.

Phylogenomic databases

eggNOGiKOG3953. Eukaryota.
ENOG410XQC1. LUCA.
GeneTreeiENSGT00390000009402.
HOGENOMiHOG000230524.
HOVERGENiHBG055793.
InParanoidiQ5M877.
KOiK10344.
OMAiWPREQRG.
OrthoDBiEOG72C513.
PhylomeDBiQ5M877.
TreeFamiTF312822.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-RNO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

NextBioi642443.
PROiQ5M877.

Gene expression databases

GenevisibleiQ5M877. RN.

Family and domain databases

InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR001496. SOCS_box.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF07525. SOCS_box. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiSPSB2_RAT
AccessioniPrimary (citable) accession number: Q5M877
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: February 1, 2005
Last modified: May 11, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.