Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SPRY domain-containing SOCS box protein 2

Gene

Spsb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-8951664. Neddylation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
SPRY domain-containing SOCS box protein 2
Short name:
SSB-2
Gene namesi
Name:Spsb2
Synonyms:Ssb2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 4, Chromosome 9

Organism-specific databases

RGDi1310854. Spsb2.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002384761 – 264SPRY domain-containing SOCS box protein 2Add BLAST264

Proteomic databases

PaxDbiQ5M877.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015125.
GenevisibleiQ5M877. RN.

Interactioni

Subunit structurei

Component of the probable ECS(SPSB2) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB2. Interacts with CUL5, RNF7, ELOB and ELOC. Interacts with MET. Interacts (via B30.2/SPRY domain) with PAWR; this interaction occurs in association with the Elongin BC complex.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064453.

Structurei

3D structure databases

ProteinModelPortaliQ5M877.
SMRiQ5M877.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 221B30.2/SPRYPROSITE-ProRule annotationAdd BLAST196
Domaini222 – 264SOCS boxPROSITE-ProRule annotationAdd BLAST43

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Belongs to the SPSB family.Curated

Phylogenomic databases

eggNOGiKOG3953. Eukaryota.
ENOG410XQC1. LUCA.
GeneTreeiENSGT00390000009402.
HOGENOMiHOG000230524.
HOVERGENiHBG055793.
InParanoidiQ5M877.
KOiK10344.
OMAiISWPREQ.
OrthoDBiEOG091G0DF0.
PhylomeDBiQ5M877.
TreeFamiTF312822.

Family and domain databases

InterProiView protein in InterPro
IPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom_sf.
IPR001496. SOCS_box.
IPR036036. SOCS_box-like_dom_sf.
IPR003877. SPRY_dom.
PfamiView protein in Pfam
PF07525. SOCS_box. 1 hit.
PF00622. SPRY. 1 hit.
SMARTiView protein in SMART
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
SM00449. SPRY. 1 hit.
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS50188. B302_SPRY. 1 hit.
PS50225. SOCS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5M877-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQTALARGS SSTPSSHALY SDLSPPEGLE ELLSAPPPDL GAQRHHGWNP
60 70 80 90 100
KDCSENIDVK EGGLCFERRP VAQSTDGVRG KRGYSRGLHA WEISWPLEQR
110 120 130 140 150
GTHAVVGVAT ALAPLQADHY AALLGSNSES WGWDIGRGKL YHQSKGLEAP
160 170 180 190 200
QYPAGPQGEQ LVVPERLLVV LDMEEGTLGY SIGGTYLGPA FRGLKGRTLY
210 220 230 240 250
PSVSAVWGQC QVRIRYLGER RAEEPQSLLH LSRLCVRHAL GDTRLGQISS
260
LPLPPAMKRY LLYK
Length:264
Mass (Da):28,797
Last modified:February 1, 2005 - v1
Checksum:i2C3578010FE81C02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088189 mRNA. Translation: AAH88189.1.
RefSeqiNP_001009660.1. NM_001009660.1.
XP_003750703.1. XM_003750655.4.
UniGeneiRn.162769.

Genome annotation databases

EnsembliENSRNOT00000020493; ENSRNOP00000020493; ENSRNOG00000015125.
ENSRNOT00000072086; ENSRNOP00000064453; ENSRNOG00000047113.
GeneIDi100911548.
297592.
KEGGirno:100911548.
rno:297592.
UCSCiRGD:1310854. rat.

Similar proteinsi

Entry informationi

Entry nameiSPSB2_RAT
AccessioniPrimary (citable) accession number: Q5M877
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: February 1, 2005
Last modified: November 22, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families