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Protein

Dipeptidase 2

Gene

Dpep2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4).By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by L-penicillamine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi90Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi92Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi189Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi189Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei216SubstratePROSITE-ProRule annotation1
Metal bindingi262Zinc 2; catalyticPROSITE-ProRule annotation1
Metal bindingi283Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei294SubstratePROSITE-ProRule annotation1
Binding sitei352SubstratePROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM19.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidase 2 (EC:3.4.13.19)
Gene namesi
Name:Dpep2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1305746. Dpep2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000023160731 – 462Dipeptidase 2Add BLAST432
PropeptideiPRO_0000231608463 – 481Removed in mature formSequence analysisAdd BLAST19

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi112N-linked (GlcNAc...)By similarity1
Disulfide bondi139 ↔ 218PROSITE-ProRule annotation
Glycosylationi177N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi290 ↔ 322PROSITE-ProRule annotation
Disulfide bondi427InterchainPROSITE-ProRule annotation
Lipidationi462GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ5M872.
PRIDEiQ5M872.

Expressioni

Gene expression databases

BgeeiENSRNOG00000023303.
GenevisibleiQ5M872. RN.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.PROSITE-ProRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031955.

Structurei

3D structure databases

ProteinModelPortaliQ5M872.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4127. Eukaryota.
COG2355. LUCA.
GeneTreeiENSGT00390000017920.
HOGENOMiHOG000072016.
HOVERGENiHBG002339.
InParanoidiQ5M872.
KOiK01273.
OMAiSFYNNVT.
OrthoDBiEOG091G09CU.
PhylomeDBiQ5M872.
TreeFamiTF324523.

Family and domain databases

CDDicd01301. rDP_like. 1 hit.
InterProiIPR000180. Dipep_AS.
IPR028531. Dpep2.
IPR032466. Metal_Hydrolase.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PTHR10443:SF9. PTHR10443:SF9. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5M872-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKGLEGHW VLSQVFLLVV VLLLLGPSEP LIRAQTKPGI ADASTAPSPL
60 70 80 90 100
RTLTKPAIFS IPTTPGNPNF PDLRDRTRAL MQDFPLIDGH NDLPLVLRQF
110 120 130 140 150
YQNGLQDTNL RNFTHGQTSL NRLKDGFVGA QFWSAYVPCQ TQDRDALRLT
160 170 180 190 200
LEQIDLIRRM CASYSELELV TSVQALNSTQ KLACLIGVEG GHSLDNSLAV
210 220 230 240 250
LRSFYLLGVR YLTLTHTCNT PWAESSSKDV HSFYSSVKGL TSFGEKVVAE
260 270 280 290 300
MNRLGMMIDL SHVSDATARQ ALEVSQAPVI FSHSAARAVC PNARNLPDDI
310 320 330 340 350
LQLLKKNGGI VMVTFAVGVL PCNPLANVST VADHFDHIRT VIGSEFIGVG
360 370 380 390 400
GDYDGTKQFP QGLEDVSTYP VLIEELLRRG WGEQELQGVL RGNLLRVFRQ
410 420 430 440 450
VEQVREKNKW QSPLEDMIPE EQLDSACHSV LPHRRQYPEK DPPETPDSHT
460 470 480
HKLSPKMPYS KSSPLRASSL TIMATFLGLL I
Length:481
Mass (Da):53,285
Last modified:February 1, 2005 - v1
Checksum:iDC39B50C10A96AC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088195 mRNA. Translation: AAH88195.1.
RefSeqiNP_001011928.1. NM_001011928.1.
UniGeneiRn.20731.

Genome annotation databases

EnsembliENSRNOT00000034722; ENSRNOP00000031955; ENSRNOG00000023303.
GeneIDi291984.
KEGGirno:291984.
UCSCiRGD:1305746. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088195 mRNA. Translation: AAH88195.1.
RefSeqiNP_001011928.1. NM_001011928.1.
UniGeneiRn.20731.

3D structure databases

ProteinModelPortaliQ5M872.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031955.

Protein family/group databases

MEROPSiM19.004.

Proteomic databases

PaxDbiQ5M872.
PRIDEiQ5M872.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000034722; ENSRNOP00000031955; ENSRNOG00000023303.
GeneIDi291984.
KEGGirno:291984.
UCSCiRGD:1305746. rat.

Organism-specific databases

CTDi64174.
RGDi1305746. Dpep2.

Phylogenomic databases

eggNOGiKOG4127. Eukaryota.
COG2355. LUCA.
GeneTreeiENSGT00390000017920.
HOGENOMiHOG000072016.
HOVERGENiHBG002339.
InParanoidiQ5M872.
KOiK01273.
OMAiSFYNNVT.
OrthoDBiEOG091G09CU.
PhylomeDBiQ5M872.
TreeFamiTF324523.

Miscellaneous databases

PROiQ5M872.

Gene expression databases

BgeeiENSRNOG00000023303.
GenevisibleiQ5M872. RN.

Family and domain databases

CDDicd01301. rDP_like. 1 hit.
InterProiIPR000180. Dipep_AS.
IPR028531. Dpep2.
IPR032466. Metal_Hydrolase.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PTHR10443:SF9. PTHR10443:SF9. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPEP2_RAT
AccessioniPrimary (citable) accession number: Q5M872
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 1, 2005
Last modified: November 30, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.