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Q5M872

- DPEP2_RAT

UniProt

Q5M872 - DPEP2_RAT

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Protein

Dipeptidase 2

Gene

Dpep2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4).By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zinc.PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by L-penicillamine.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi90 – 901Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi92 – 921Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi189 – 1891Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi189 – 1891Zinc 2; catalyticPROSITE-ProRule annotation
Binding sitei216 – 2161SubstratePROSITE-ProRule annotation
Metal bindingi262 – 2621Zinc 2; catalyticPROSITE-ProRule annotation
Metal bindingi283 – 2831Zinc 2; catalyticPROSITE-ProRule annotation
Binding sitei294 – 2941SubstratePROSITE-ProRule annotation
Binding sitei352 – 3521SubstratePROSITE-ProRule annotation

GO - Molecular functioni

  1. dipeptidase activity Source: UniProtKB-KW
  2. dipeptidyl-peptidase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. metalloexopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_197237. Synthesis of Leukotrienes (LT) and Eoxins (EX).

Protein family/group databases

MEROPSiM19.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidase 2 (EC:3.4.13.19)
Gene namesi
Name:Dpep2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 19

Organism-specific databases

RGDi1305746. Dpep2.

Subcellular locationi

Membrane By similarity; Lipid-anchorGPI-anchor By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 462432Dipeptidase 2PRO_0000231607Add
BLAST
Propeptidei463 – 48119Removed in mature formSequence AnalysisPRO_0000231608Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi112 – 1121N-linked (GlcNAc...)By similarity
Disulfide bondi139 ↔ 218PROSITE-ProRule annotation
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi290 ↔ 322PROSITE-ProRule annotation
Disulfide bondi427 – 427InterchainPROSITE-ProRule annotation
Lipidationi462 – 4621GPI-anchor amidated serineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiQ5M872.

Expressioni

Gene expression databases

GenevestigatoriQ5M872.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.PROSITE-ProRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031955.

Structurei

3D structure databases

ProteinModelPortaliQ5M872.
SMRiQ5M872. Positions 72-430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2355.
GeneTreeiENSGT00390000017920.
HOGENOMiHOG000072016.
HOVERGENiHBG002339.
InParanoidiQ5M872.
OMAiDTQKLAC.
OrthoDBiEOG7SJD4N.
PhylomeDBiQ5M872.
TreeFamiTF324523.

Family and domain databases

InterProiIPR000180. Dipep_AS.
IPR028531. Dpep2.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PTHR10443:SF9. PTHR10443:SF9. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5M872-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLKGLEGHW VLSQVFLLVV VLLLLGPSEP LIRAQTKPGI ADASTAPSPL
60 70 80 90 100
RTLTKPAIFS IPTTPGNPNF PDLRDRTRAL MQDFPLIDGH NDLPLVLRQF
110 120 130 140 150
YQNGLQDTNL RNFTHGQTSL NRLKDGFVGA QFWSAYVPCQ TQDRDALRLT
160 170 180 190 200
LEQIDLIRRM CASYSELELV TSVQALNSTQ KLACLIGVEG GHSLDNSLAV
210 220 230 240 250
LRSFYLLGVR YLTLTHTCNT PWAESSSKDV HSFYSSVKGL TSFGEKVVAE
260 270 280 290 300
MNRLGMMIDL SHVSDATARQ ALEVSQAPVI FSHSAARAVC PNARNLPDDI
310 320 330 340 350
LQLLKKNGGI VMVTFAVGVL PCNPLANVST VADHFDHIRT VIGSEFIGVG
360 370 380 390 400
GDYDGTKQFP QGLEDVSTYP VLIEELLRRG WGEQELQGVL RGNLLRVFRQ
410 420 430 440 450
VEQVREKNKW QSPLEDMIPE EQLDSACHSV LPHRRQYPEK DPPETPDSHT
460 470 480
HKLSPKMPYS KSSPLRASSL TIMATFLGLL I
Length:481
Mass (Da):53,285
Last modified:February 1, 2005 - v1
Checksum:iDC39B50C10A96AC1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC088195 mRNA. Translation: AAH88195.1.
RefSeqiNP_001011928.1. NM_001011928.1.
UniGeneiRn.20731.

Genome annotation databases

EnsembliENSRNOT00000034722; ENSRNOP00000031955; ENSRNOG00000023303.
GeneIDi291984.
KEGGirno:291984.
UCSCiRGD:1305746. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC088195 mRNA. Translation: AAH88195.1 .
RefSeqi NP_001011928.1. NM_001011928.1.
UniGenei Rn.20731.

3D structure databases

ProteinModelPortali Q5M872.
SMRi Q5M872. Positions 72-430.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000031955.

Protein family/group databases

MEROPSi M19.004.

Proteomic databases

PRIDEi Q5M872.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000034722 ; ENSRNOP00000031955 ; ENSRNOG00000023303 .
GeneIDi 291984.
KEGGi rno:291984.
UCSCi RGD:1305746. rat.

Organism-specific databases

CTDi 64174.
RGDi 1305746. Dpep2.

Phylogenomic databases

eggNOGi COG2355.
GeneTreei ENSGT00390000017920.
HOGENOMi HOG000072016.
HOVERGENi HBG002339.
InParanoidi Q5M872.
OMAi DTQKLAC.
OrthoDBi EOG7SJD4N.
PhylomeDBi Q5M872.
TreeFami TF324523.

Enzyme and pathway databases

Reactomei REACT_197237. Synthesis of Leukotrienes (LT) and Eoxins (EX).

Miscellaneous databases

NextBioi 633560.
PROi Q5M872.

Gene expression databases

Genevestigatori Q5M872.

Family and domain databases

InterProi IPR000180. Dipep_AS.
IPR028531. Dpep2.
IPR008257. Renal_dipep_fam.
[Graphical view ]
PANTHERi PTHR10443. PTHR10443. 1 hit.
PTHR10443:SF9. PTHR10443:SF9. 1 hit.
Pfami PF01244. Peptidase_M19. 1 hit.
[Graphical view ]
PROSITEi PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiDPEP2_RAT
AccessioniPrimary (citable) accession number: Q5M872
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 1, 2005
Last modified: October 1, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3