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Q5M872

- DPEP2_RAT

UniProt

Q5M872 - DPEP2_RAT

Protein

Dipeptidase 2

Gene

Dpep2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4).By similarity

    Catalytic activityi

    Hydrolysis of dipeptides.PROSITE-ProRule annotation

    Cofactori

    Zinc.PROSITE-ProRule annotation

    Enzyme regulationi

    Inhibited by L-penicillamine.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi90 – 901Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi92 – 921Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi189 – 1891Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi189 – 1891Zinc 2; catalyticPROSITE-ProRule annotation
    Binding sitei216 – 2161SubstratePROSITE-ProRule annotation
    Metal bindingi262 – 2621Zinc 2; catalyticPROSITE-ProRule annotation
    Metal bindingi283 – 2831Zinc 2; catalyticPROSITE-ProRule annotation
    Binding sitei294 – 2941SubstratePROSITE-ProRule annotation
    Binding sitei352 – 3521SubstratePROSITE-ProRule annotation

    GO - Molecular functioni

    1. dipeptidase activity Source: UniProtKB-KW
    2. dipeptidyl-peptidase activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW
    4. metalloexopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Dipeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_197237. Synthesis of Leukotrienes (LT) and Eoxins (EX).

    Protein family/group databases

    MEROPSiM19.004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dipeptidase 2 (EC:3.4.13.19)
    Gene namesi
    Name:Dpep2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 19

    Organism-specific databases

    RGDi1305746. Dpep2.

    Subcellular locationi

    Membrane By similarity; Lipid-anchorGPI-anchor By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 462432Dipeptidase 2PRO_0000231607Add
    BLAST
    Propeptidei463 – 48119Removed in mature formSequence AnalysisPRO_0000231608Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi112 – 1121N-linked (GlcNAc...)By similarity
    Disulfide bondi139 ↔ 218PROSITE-ProRule annotation
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi290 ↔ 322PROSITE-ProRule annotation
    Disulfide bondi427 – 427InterchainPROSITE-ProRule annotation
    Lipidationi462 – 4621GPI-anchor amidated serineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PRIDEiQ5M872.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5M872.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.PROSITE-ProRule annotation

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000031955.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5M872.
    SMRiQ5M872. Positions 72-430.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M19 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2355.
    GeneTreeiENSGT00390000017920.
    HOGENOMiHOG000072016.
    HOVERGENiHBG002339.
    InParanoidiQ5M872.
    OMAiDTQKLAC.
    OrthoDBiEOG7SJD4N.
    PhylomeDBiQ5M872.
    TreeFamiTF324523.

    Family and domain databases

    InterProiIPR000180. Dipep_AS.
    IPR028531. Dpep2.
    IPR008257. Renal_dipep_fam.
    [Graphical view]
    PANTHERiPTHR10443. PTHR10443. 1 hit.
    PTHR10443:SF9. PTHR10443:SF9. 1 hit.
    PfamiPF01244. Peptidase_M19. 1 hit.
    [Graphical view]
    PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
    PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5M872-1 [UniParc]FASTAAdd to Basket

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    MSLKGLEGHW VLSQVFLLVV VLLLLGPSEP LIRAQTKPGI ADASTAPSPL    50
    RTLTKPAIFS IPTTPGNPNF PDLRDRTRAL MQDFPLIDGH NDLPLVLRQF 100
    YQNGLQDTNL RNFTHGQTSL NRLKDGFVGA QFWSAYVPCQ TQDRDALRLT 150
    LEQIDLIRRM CASYSELELV TSVQALNSTQ KLACLIGVEG GHSLDNSLAV 200
    LRSFYLLGVR YLTLTHTCNT PWAESSSKDV HSFYSSVKGL TSFGEKVVAE 250
    MNRLGMMIDL SHVSDATARQ ALEVSQAPVI FSHSAARAVC PNARNLPDDI 300
    LQLLKKNGGI VMVTFAVGVL PCNPLANVST VADHFDHIRT VIGSEFIGVG 350
    GDYDGTKQFP QGLEDVSTYP VLIEELLRRG WGEQELQGVL RGNLLRVFRQ 400
    VEQVREKNKW QSPLEDMIPE EQLDSACHSV LPHRRQYPEK DPPETPDSHT 450
    HKLSPKMPYS KSSPLRASSL TIMATFLGLL I 481
    Length:481
    Mass (Da):53,285
    Last modified:February 1, 2005 - v1
    Checksum:iDC39B50C10A96AC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC088195 mRNA. Translation: AAH88195.1.
    RefSeqiNP_001011928.1. NM_001011928.1.
    UniGeneiRn.20731.

    Genome annotation databases

    EnsembliENSRNOT00000034722; ENSRNOP00000031955; ENSRNOG00000023303.
    GeneIDi291984.
    KEGGirno:291984.
    UCSCiRGD:1305746. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC088195 mRNA. Translation: AAH88195.1 .
    RefSeqi NP_001011928.1. NM_001011928.1.
    UniGenei Rn.20731.

    3D structure databases

    ProteinModelPortali Q5M872.
    SMRi Q5M872. Positions 72-430.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000031955.

    Protein family/group databases

    MEROPSi M19.004.

    Proteomic databases

    PRIDEi Q5M872.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000034722 ; ENSRNOP00000031955 ; ENSRNOG00000023303 .
    GeneIDi 291984.
    KEGGi rno:291984.
    UCSCi RGD:1305746. rat.

    Organism-specific databases

    CTDi 64174.
    RGDi 1305746. Dpep2.

    Phylogenomic databases

    eggNOGi COG2355.
    GeneTreei ENSGT00390000017920.
    HOGENOMi HOG000072016.
    HOVERGENi HBG002339.
    InParanoidi Q5M872.
    OMAi DTQKLAC.
    OrthoDBi EOG7SJD4N.
    PhylomeDBi Q5M872.
    TreeFami TF324523.

    Enzyme and pathway databases

    Reactomei REACT_197237. Synthesis of Leukotrienes (LT) and Eoxins (EX).

    Miscellaneous databases

    NextBioi 633560.
    PROi Q5M872.

    Gene expression databases

    Genevestigatori Q5M872.

    Family and domain databases

    InterProi IPR000180. Dipep_AS.
    IPR028531. Dpep2.
    IPR008257. Renal_dipep_fam.
    [Graphical view ]
    PANTHERi PTHR10443. PTHR10443. 1 hit.
    PTHR10443:SF9. PTHR10443:SF9. 1 hit.
    Pfami PF01244. Peptidase_M19. 1 hit.
    [Graphical view ]
    PROSITEi PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
    PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.

    Entry informationi

    Entry nameiDPEP2_RAT
    AccessioniPrimary (citable) accession number: Q5M872
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3