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Protein

Dipeptidase 2

Gene

Dpep2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4).By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by L-penicillamine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi90Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi92Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi189Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi189Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei216SubstratePROSITE-ProRule annotation1
Metal bindingi262Zinc 2; catalyticPROSITE-ProRule annotation1
Metal bindingi283Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei294SubstratePROSITE-ProRule annotation1
Binding sitei352SubstratePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionDipeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM19.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidase 2 (EC:3.4.13.19)
Gene namesi
Name:Dpep2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1305746. Dpep2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000023160731 – 462Dipeptidase 2Add BLAST432
PropeptideiPRO_0000231608463 – 481Removed in mature formSequence analysisAdd BLAST19

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi112N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi139 ↔ 218PROSITE-ProRule annotation
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi290 ↔ 322PROSITE-ProRule annotation
Disulfide bondi427InterchainPROSITE-ProRule annotation
Lipidationi462GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ5M872.
PRIDEiQ5M872.

Expressioni

Gene expression databases

BgeeiENSRNOG00000023303.
GenevisibleiQ5M872. RN.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.PROSITE-ProRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031955.

Structurei

3D structure databases

ProteinModelPortaliQ5M872.
SMRiQ5M872.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4127. Eukaryota.
COG2355. LUCA.
GeneTreeiENSGT00390000017920.
HOGENOMiHOG000072016.
HOVERGENiHBG002339.
InParanoidiQ5M872.
KOiK01273.
OMAiFPVLILW.
OrthoDBiEOG091G09CU.
PhylomeDBiQ5M872.
TreeFamiTF324523.

Family and domain databases

CDDicd01301. rDP_like. 1 hit.
InterProiView protein in InterPro
IPR000180. Dipep_AS.
IPR032466. Metal_Hydrolase.
IPR008257. Renal_dipep_fam.
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiView protein in Pfam
PF01244. Peptidase_M19. 1 hit.
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiView protein in PROSITE
PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5M872-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKGLEGHW VLSQVFLLVV VLLLLGPSEP LIRAQTKPGI ADASTAPSPL
60 70 80 90 100
RTLTKPAIFS IPTTPGNPNF PDLRDRTRAL MQDFPLIDGH NDLPLVLRQF
110 120 130 140 150
YQNGLQDTNL RNFTHGQTSL NRLKDGFVGA QFWSAYVPCQ TQDRDALRLT
160 170 180 190 200
LEQIDLIRRM CASYSELELV TSVQALNSTQ KLACLIGVEG GHSLDNSLAV
210 220 230 240 250
LRSFYLLGVR YLTLTHTCNT PWAESSSKDV HSFYSSVKGL TSFGEKVVAE
260 270 280 290 300
MNRLGMMIDL SHVSDATARQ ALEVSQAPVI FSHSAARAVC PNARNLPDDI
310 320 330 340 350
LQLLKKNGGI VMVTFAVGVL PCNPLANVST VADHFDHIRT VIGSEFIGVG
360 370 380 390 400
GDYDGTKQFP QGLEDVSTYP VLIEELLRRG WGEQELQGVL RGNLLRVFRQ
410 420 430 440 450
VEQVREKNKW QSPLEDMIPE EQLDSACHSV LPHRRQYPEK DPPETPDSHT
460 470 480
HKLSPKMPYS KSSPLRASSL TIMATFLGLL I
Length:481
Mass (Da):53,285
Last modified:February 1, 2005 - v1
Checksum:iDC39B50C10A96AC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088195 mRNA. Translation: AAH88195.1.
RefSeqiNP_001011928.1. NM_001011928.1.
UniGeneiRn.20731.

Genome annotation databases

EnsembliENSRNOT00000034722; ENSRNOP00000031955; ENSRNOG00000023303.
GeneIDi291984.
KEGGirno:291984.
UCSCiRGD:1305746. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDPEP2_RAT
AccessioniPrimary (citable) accession number: Q5M872
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 1, 2005
Last modified: July 5, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families