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Protein

Fas apoptotic inhibitory molecule 3

Gene

Fcmr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
Fas apoptotic inhibitory molecule 3By similarity
Alternative name(s):
IgM Fc fragment receptorBy similarityImported
Regulator of Fas-induced apoptosis TosoBy similarity
Gene namesi
Name:FcmrBy similarityImported
Synonyms:Faim3, Toso
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359282. Fcmr.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000028442318 – 426Fas apoptotic inhibitory molecule 3Add BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 103By similarity
Modified residuei91PhosphothreonineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ5M871.
PRIDEiQ5M871.

PTM databases

iPTMnetiQ5M871.
PhosphoSitePlusiQ5M871.

Expressioni

Gene expression databases

GenevisibleiQ5M871. RN.

Structurei

3D structure databases

ProteinModelPortaliQ5M871.
SMRiQ5M871.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 104Ig-likeAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi289 – 343Arg-richAdd BLAST55

Domaini

The Ig-like domain is required for the anti-apoptotic ability.By similarity

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ2J. Eukaryota.
ENOG41113GQ. LUCA.
HOGENOMiHOG000013142.
HOVERGENiHBG107910.
InParanoidiQ5M871.
OrthoDBiEOG091G0K4T.
PhylomeDBiQ5M871.
TreeFamiTF338713.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5M871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLWLWLLYF LPVSGTLKVL PEVRLEVELG GSVFIECPLP QTHVRMYLCR
60 70 80 90 100
QMTNPAICAT VVSNIFVKKE YKRRVTLKPS LNKKLFLVEM TQLTKDDEGI
110 120 130 140 150
YACGVGTNTD LGKTQKVTLN VRNEFPEYPE PFWDDEPTSE PSPRWWLHRY
160 170 180 190 200
PEELPWLKMG EHASPSGFID KVTTLSPKTE APPVHQPSTN TSVSRHPRVY
210 220 230 240 250
GASSETPTKP SALLPATTAF KTSARQASRL LEASYSHHTR LHGERTPHYG
260 270 280 290 300
SQYGREDRGL HISIPEFHIL IPTFLGFLLL VLLGLVVKRA IQRRRAFSRR
310 320 330 340 350
VGRMARRMRG RGPSRQIPTQ RRDAPQRPRS QNNVYSACPR RAREPDNVGS
360 370 380 390 400
AEALLLNAPA SAPPALPLVI ETSWPHTPSL KMSCEYVSLG HQPAVNVEDQ
410 420
DSNDYINIPG LPHLPSKPPG PRPSRQ
Length:426
Mass (Da):48,055
Last modified:February 1, 2005 - v1
Checksum:iB8CE97B14EE46EA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088197 mRNA. Translation: AAH88197.1.
RefSeqiNP_001014843.1. NM_001014843.2.
UniGeneiRn.23441.

Genome annotation databases

GeneIDi548326.
KEGGirno:548326.
UCSCiRGD:1359282. rat.

Similar proteinsi

Entry informationi

Entry nameiFAIM3_RAT
AccessioniPrimary (citable) accession number: Q5M871
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: February 1, 2005
Last modified: November 22, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome