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Protein

Fas apoptotic inhibitory molecule 3

Gene

Fcmr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Fas apoptotic inhibitory molecule 3By similarity
Alternative name(s):
IgM Fc fragment receptorBy similarityImported
Regulator of Fas-induced apoptosis TosoBy similarity
Gene namesi
Name:FcmrBy similarityImported
Synonyms:Faim3, Toso
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359282. Fcmr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei267 – 28721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 426409Fas apoptotic inhibitory molecule 3PRO_0000284423Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 103By similarity
Modified residuei91 – 911PhosphothreonineCombined sources

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ5M871.
PRIDEiQ5M871.

PTM databases

iPTMnetiQ5M871.
PhosphoSiteiQ5M871.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004441.
GenevisibleiQ5M871. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036615.

Structurei

3D structure databases

ProteinModelPortaliQ5M871.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 10472Ig-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi289 – 34355Arg-richAdd
BLAST

Domaini

The Ig-like domain is required for the anti-apoptotic ability.By similarity

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ2J. Eukaryota.
ENOG41113GQ. LUCA.
HOGENOMiHOG000013142.
HOVERGENiHBG107910.
InParanoidiQ5M871.
OrthoDBiEOG091G0K4T.
PhylomeDBiQ5M871.
TreeFamiTF338713.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5M871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLWLWLLYF LPVSGTLKVL PEVRLEVELG GSVFIECPLP QTHVRMYLCR
60 70 80 90 100
QMTNPAICAT VVSNIFVKKE YKRRVTLKPS LNKKLFLVEM TQLTKDDEGI
110 120 130 140 150
YACGVGTNTD LGKTQKVTLN VRNEFPEYPE PFWDDEPTSE PSPRWWLHRY
160 170 180 190 200
PEELPWLKMG EHASPSGFID KVTTLSPKTE APPVHQPSTN TSVSRHPRVY
210 220 230 240 250
GASSETPTKP SALLPATTAF KTSARQASRL LEASYSHHTR LHGERTPHYG
260 270 280 290 300
SQYGREDRGL HISIPEFHIL IPTFLGFLLL VLLGLVVKRA IQRRRAFSRR
310 320 330 340 350
VGRMARRMRG RGPSRQIPTQ RRDAPQRPRS QNNVYSACPR RAREPDNVGS
360 370 380 390 400
AEALLLNAPA SAPPALPLVI ETSWPHTPSL KMSCEYVSLG HQPAVNVEDQ
410 420
DSNDYINIPG LPHLPSKPPG PRPSRQ
Length:426
Mass (Da):48,055
Last modified:February 1, 2005 - v1
Checksum:iB8CE97B14EE46EA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088197 mRNA. Translation: AAH88197.1.
RefSeqiNP_001014843.1. NM_001014843.2.
UniGeneiRn.23441.

Genome annotation databases

GeneIDi548326.
KEGGirno:548326.
UCSCiRGD:1359282. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088197 mRNA. Translation: AAH88197.1.
RefSeqiNP_001014843.1. NM_001014843.2.
UniGeneiRn.23441.

3D structure databases

ProteinModelPortaliQ5M871.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036615.

PTM databases

iPTMnetiQ5M871.
PhosphoSiteiQ5M871.

Proteomic databases

PaxDbiQ5M871.
PRIDEiQ5M871.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi548326.
KEGGirno:548326.
UCSCiRGD:1359282. rat.

Organism-specific databases

CTDi9214.
RGDi1359282. Fcmr.

Phylogenomic databases

eggNOGiENOG410IJ2J. Eukaryota.
ENOG41113GQ. LUCA.
HOGENOMiHOG000013142.
HOVERGENiHBG107910.
InParanoidiQ5M871.
OrthoDBiEOG091G0K4T.
PhylomeDBiQ5M871.
TreeFamiTF338713.

Miscellaneous databases

PROiQ5M871.

Gene expression databases

BgeeiENSRNOG00000004441.
GenevisibleiQ5M871. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFAIM3_RAT
AccessioniPrimary (citable) accession number: Q5M871
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: February 1, 2005
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.