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Q5M848 (CRCM1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Calcium release-activated calcium channel protein 1
Alternative name(s):
Protein orai-1
Transmembrane protein 142A
Gene names
Name:Orai1
Synonyms:Cracm1, Tmem142a
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ca2+ release-activated Ca2+ (CRAC) channel subunit which mediates Ca2+ influx following depletion of intracellular Ca2+ stores and channel activation by the Ca2+ sensor, STIM1. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT By similarity.

Subunit structure

Interacts with STIM1 and STIM2. Interacts with EFCAB4B/CRACR2A; the interaction is direct and takes place in absence of Ca2+. Forms a complex with EFCAB4B/CRACR2A and STIM1 at low concentration of Ca2+, the complex dissociates at elevated Ca2+ concentrations By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the Orai family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 304304Calcium release-activated calcium channel protein 1
PRO_0000234383

Regions

Topological domain1 – 8888Cytoplasmic Potential
Transmembrane89 – 10618Helical; Potential
Topological domain107 – 12014Extracellular Potential
Transmembrane121 – 14121Helical; Potential
Topological domain142 – 17433Cytoplasmic Potential
Transmembrane175 – 19521Helical; Potential
Topological domain196 – 23742Extracellular Potential
Transmembrane238 – 25821Helical; Potential
Topological domain259 – 30446Cytoplasmic Potential
Compositional bias43 – 497Poly-Pro

Amino acid modifications

Modified residue2981Phosphothreonine By similarity
Glycosylation2251N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5M848 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 98264D8880982C74

FASTA30433,040
        10         20         30         40         50         60 
MHPEPAPPPN NSNPELPLSG GSSTSGSRRS RRRSGDGEPT GAPPLPPPPA VSYPDWIGQS 

        70         80         90        100        110        120 
YSEVMSLNEH SMQALSWRKL YLSRAKLKAS SRTSALLSGF AMVAMVEVQL DTDHDYPPGL 

       130        140        150        160        170        180 
LIVFSACTTV LVAVHLFALM ISTCILPNIE AVSNVHNLNS VKESPHERMH RHIELAWAFS 

       190        200        210        220        230        240 
TVIGTLLFLA EVVLLCWVKF LPLKRQAGQP SPTKPPTEPA VVVANSSNNG GITPGEAAAI 

       250        260        270        280        290        300 
ASTAIMVPCG LVFIVFAVHF YRSLVSHKTD RQFQELNELA EFARLQDQLD HRGDHSLTPG 


THYA

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC088225 mRNA. Translation: AAH88225.1.
IPIIPI00370905.
RefSeqNP_001014004.1. NM_001013982.1.
UniGeneRn.3869.

3D structure databases

ModBaseSearch...

Proteomic databases

PaxDbQ5M848.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID304496.
KEGGrno:304496.
UCSCRGD:1311873. rat.

Organism-specific databases

CTD84876.
RGD1311873. Orai1.

Phylogenomic databases

eggNOGNOG263788.
HOGENOMHOG000246925.
HOVERGENHBG081343.
KOK16056.
OrthoDBEOG4WH8MR.

Gene expression databases

ArrayExpressQ5M848.
GenevestigatorQ5M848.
GermOnlineENSRNOG00000001336. Rattus norvegicus.

Family and domain databases

InterProIPR012446. CRAC_channel.
[Graphical view]
PfamPF07856. Orai-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio653128.

Entry information

Entry nameCRCM1_RAT
AccessionPrimary (citable) accession number: Q5M848
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: February 1, 2005
Last modified: May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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