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Q5M840

- G0S2_RAT

UniProt

Q5M840 - G0S2_RAT

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Protein

G0/G1 switch protein 2

Gene

G0s2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.By similarity

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. extrinsic apoptotic signaling pathway Source: UniProtKB
  3. positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle

Enzyme and pathway databases

ReactomeiREACT_196408. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
G0/G1 switch protein 2
Alternative name(s):
G0S2-like protein
Gene namesi
Name:G0s2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi1311675. G0s2.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 103103G0/G1 switch protein 2PRO_0000416594Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ5M840.

Interactioni

Subunit structurei

Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007879.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG45933.
GeneTreeiENSGT00390000005294.
HOGENOMiHOG000112682.
HOVERGENiHBG004465.
InParanoidiQ5M840.
OMAiKELMAHK.
OrthoDBiEOG7FBRMG.
PhylomeDBiQ5M840.
TreeFamiTF336218.

Family and domain databases

InterProiIPR016821. G0S2.
[Graphical view]
PfamiPF15103. G0-G1_switch_2. 1 hit.
[Graphical view]
PIRSFiPIRSF023925. G0/G1_switch_p2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5M840-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESVQELIPL AKEMMTQKSR GKLVKLYVLG SVLAFFGVVL GLVETVCSPF
60 70 80 90 100
TAASRLRDQE AAVAELRDAC EQQSLHKQAL IAEGKTQEAT LCSRALSLRQ

HAS
Length:103
Mass (Da):11,232
Last modified:February 1, 2005 - v1
Checksum:iB921FAB9D9AB709A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473985 Genomic DNA. Translation: EDL95033.1.
BC088248 mRNA. Translation: AAH88248.1.
RefSeqiNP_001009632.1. NM_001009632.1.
UniGeneiRn.1040.

Genome annotation databases

EnsembliENSRNOT00000007879; ENSRNOP00000007879; ENSRNOG00000006019.
GeneIDi289388.
KEGGirno:289388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473985 Genomic DNA. Translation: EDL95033.1 .
BC088248 mRNA. Translation: AAH88248.1 .
RefSeqi NP_001009632.1. NM_001009632.1.
UniGenei Rn.1040.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000007879.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000007879 ; ENSRNOP00000007879 ; ENSRNOG00000006019 .
GeneIDi 289388.
KEGGi rno:289388.

Organism-specific databases

CTDi 50486.
RGDi 1311675. G0s2.

Phylogenomic databases

eggNOGi NOG45933.
GeneTreei ENSGT00390000005294.
HOGENOMi HOG000112682.
HOVERGENi HBG004465.
InParanoidi Q5M840.
OMAi KELMAHK.
OrthoDBi EOG7FBRMG.
PhylomeDBi Q5M840.
TreeFami TF336218.

Enzyme and pathway databases

Reactomei REACT_196408. PPARA activates gene expression.

Miscellaneous databases

NextBioi 629752.
PROi Q5M840.

Gene expression databases

Genevestigatori Q5M840.

Family and domain databases

InterProi IPR016821. G0S2.
[Graphical view ]
Pfami PF15103. G0-G1_switch_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF023925. G0/G1_switch_p2. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiG0S2_RAT
AccessioniPrimary (citable) accession number: Q5M840
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: February 1, 2005
Last modified: October 1, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3