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Q5M840

- G0S2_RAT

UniProt

Q5M840 - G0S2_RAT

Protein

G0/G1 switch protein 2

Gene

G0s2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.By similarity

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. extrinsic apoptotic signaling pathway Source: UniProtKB
    3. positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB

    Keywords - Biological processi

    Apoptosis, Cell cycle

    Enzyme and pathway databases

    ReactomeiREACT_196408. PPARA activates gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G0/G1 switch protein 2
    Alternative name(s):
    G0S2-like protein
    Gene namesi
    Name:G0s2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi1311675. G0s2.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 103103G0/G1 switch protein 2PRO_0000416594Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriQ5M840.

    Interactioni

    Subunit structurei

    Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000007879.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG45933.
    GeneTreeiENSGT00390000005294.
    HOGENOMiHOG000112682.
    HOVERGENiHBG004465.
    InParanoidiQ5M840.
    OMAiKELMAHK.
    OrthoDBiEOG7FBRMG.
    PhylomeDBiQ5M840.
    TreeFamiTF336218.

    Family and domain databases

    InterProiIPR016821. G0S2.
    [Graphical view]
    PfamiPF15103. G0-G1_switch_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF023925. G0/G1_switch_p2. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5M840-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESVQELIPL AKEMMTQKSR GKLVKLYVLG SVLAFFGVVL GLVETVCSPF    50
    TAASRLRDQE AAVAELRDAC EQQSLHKQAL IAEGKTQEAT LCSRALSLRQ 100
    HAS 103
    Length:103
    Mass (Da):11,232
    Last modified:February 1, 2005 - v1
    Checksum:iB921FAB9D9AB709A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH473985 Genomic DNA. Translation: EDL95033.1.
    BC088248 mRNA. Translation: AAH88248.1.
    RefSeqiNP_001009632.1. NM_001009632.1.
    UniGeneiRn.1040.

    Genome annotation databases

    EnsembliENSRNOT00000007879; ENSRNOP00000007879; ENSRNOG00000006019.
    GeneIDi289388.
    KEGGirno:289388.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH473985 Genomic DNA. Translation: EDL95033.1 .
    BC088248 mRNA. Translation: AAH88248.1 .
    RefSeqi NP_001009632.1. NM_001009632.1.
    UniGenei Rn.1040.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000007879.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000007879 ; ENSRNOP00000007879 ; ENSRNOG00000006019 .
    GeneIDi 289388.
    KEGGi rno:289388.

    Organism-specific databases

    CTDi 50486.
    RGDi 1311675. G0s2.

    Phylogenomic databases

    eggNOGi NOG45933.
    GeneTreei ENSGT00390000005294.
    HOGENOMi HOG000112682.
    HOVERGENi HBG004465.
    InParanoidi Q5M840.
    OMAi KELMAHK.
    OrthoDBi EOG7FBRMG.
    PhylomeDBi Q5M840.
    TreeFami TF336218.

    Enzyme and pathway databases

    Reactomei REACT_196408. PPARA activates gene expression.

    Miscellaneous databases

    NextBioi 629752.
    PROi Q5M840.

    Gene expression databases

    Genevestigatori Q5M840.

    Family and domain databases

    InterProi IPR016821. G0S2.
    [Graphical view ]
    Pfami PF15103. G0-G1_switch_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF023925. G0/G1_switch_p2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiG0S2_RAT
    AccessioniPrimary (citable) accession number: Q5M840
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2012
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3