Q5M840 (G0S2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G0/G1 switch protein 2

Alternative name(s):
G0S2-like protein

Gene names

Name:

G0s2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	103 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers By similarity.
Subunit structure	Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex By similarity.
Subcellular location	Mitochondrion By similarity.

Ontologies

Keywords
Biological process	Apoptosis Cell cycle
Cellular component	Mitochondrion
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB cell cycle Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	mitochondrion Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 103	103	G0/G1 switch protein 2		PRO_0000416594

Sequences

	Sequence		Length	Mass (Da)
	Q5M840 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: B921FAB9D9AB709A	FASTA	103	11,232
	10 20 30 40 50 60 MESVQELIPL AKEMMTQKSR GKLVKLYVLG SVLAFFGVVL GLVETVCSPF TAASRLRDQE 70 80 90 100 AAVAELRDAC EQQSLHKQAL IAEGKTQEAT LCSRALSLRQ HAS

References

[1]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH473985 Genomic DNA. Translation: EDL95033.1. BC088248 mRNA. Translation: AAH88248.1.
IPI	IPI00371554.
RefSeq	NP_001009632.1. NM_001009632.1.
UniGene	Rn.1040.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000007879.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000007879; ENSRNOP00000007879; ENSRNOG00000006019.
GeneID	289388.
KEGG	rno:289388.
Organism-specific databases
CTD	50486.
RGD	1311675. G0s2.
Phylogenomic databases
eggNOG	NOG45933.
GeneTree	ENSGT00390000005294.
HOGENOM	HOG000112682.
HOVERGEN	HBG004465.
InParanoid	Q5M840.
OMA	KELMAHK.
OrthoDB	EOG42NJ24.
Gene expression databases
Genevestigator	Q5M840.
Family and domain databases
InterPro	IPR016821. G0/G1_switch_2_put. [Graphical view]
PIRSF	PIRSF023925. G0/G1_switch_p2. 1 hit.
ProtoNet	Search...
Other
NextBio	629752.

Entry information

Entry name

G0S2_RAT

Accession

Primary (citable) accession number: Q5M840

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 18, 2012
Last sequence update:	February 1, 2005
Last modified:	April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program