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Protein

G0/G1 switch protein 2

Gene

G0s2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.By similarity

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. extrinsic apoptotic signaling pathway Source: UniProtKB
  3. positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle

Enzyme and pathway databases

ReactomeiREACT_196408. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
G0/G1 switch protein 2
Alternative name(s):
G0S2-like protein
Gene namesi
Name:G0s2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi1311675. G0s2.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 103103G0/G1 switch protein 2PRO_0000416594Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ5M840.

Interactioni

Subunit structurei

Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007879.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG45933.
GeneTreeiENSGT00390000005294.
HOGENOMiHOG000112682.
HOVERGENiHBG004465.
InParanoidiQ5M840.
OMAiKELMAHK.
OrthoDBiEOG7FBRMG.
PhylomeDBiQ5M840.
TreeFamiTF336218.

Family and domain databases

InterProiIPR016821. G0S2.
[Graphical view]
PfamiPF15103. G0-G1_switch_2. 1 hit.
[Graphical view]
PIRSFiPIRSF023925. G0/G1_switch_p2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5M840-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESVQELIPL AKEMMTQKSR GKLVKLYVLG SVLAFFGVVL GLVETVCSPF
60 70 80 90 100
TAASRLRDQE AAVAELRDAC EQQSLHKQAL IAEGKTQEAT LCSRALSLRQ

HAS
Length:103
Mass (Da):11,232
Last modified:February 1, 2005 - v1
Checksum:iB921FAB9D9AB709A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473985 Genomic DNA. Translation: EDL95033.1.
BC088248 mRNA. Translation: AAH88248.1.
RefSeqiNP_001009632.1. NM_001009632.1.
UniGeneiRn.1040.

Genome annotation databases

EnsembliENSRNOT00000007879; ENSRNOP00000007879; ENSRNOG00000006019.
GeneIDi289388.
KEGGirno:289388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473985 Genomic DNA. Translation: EDL95033.1.
BC088248 mRNA. Translation: AAH88248.1.
RefSeqiNP_001009632.1. NM_001009632.1.
UniGeneiRn.1040.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007879.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007879; ENSRNOP00000007879; ENSRNOG00000006019.
GeneIDi289388.
KEGGirno:289388.

Organism-specific databases

CTDi50486.
RGDi1311675. G0s2.

Phylogenomic databases

eggNOGiNOG45933.
GeneTreeiENSGT00390000005294.
HOGENOMiHOG000112682.
HOVERGENiHBG004465.
InParanoidiQ5M840.
OMAiKELMAHK.
OrthoDBiEOG7FBRMG.
PhylomeDBiQ5M840.
TreeFamiTF336218.

Enzyme and pathway databases

ReactomeiREACT_196408. PPARA activates gene expression.

Miscellaneous databases

NextBioi629752.
PROiQ5M840.

Gene expression databases

GenevestigatoriQ5M840.

Family and domain databases

InterProiIPR016821. G0S2.
[Graphical view]
PfamiPF15103. G0-G1_switch_2. 1 hit.
[Graphical view]
PIRSFiPIRSF023925. G0/G1_switch_p2. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiG0S2_RAT
AccessioniPrimary (citable) accession number: Q5M840
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: February 1, 2005
Last modified: January 7, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.