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Q5M840 (G0S2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
G0/G1 switch protein 2
Alternative name(s):
G0S2-like protein
Gene names
Name:G0s2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length103 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers By similarity.

Subunit structure

Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 103103G0/G1 switch protein 2
PRO_0000416594

Sequences

Sequence LengthMass (Da)Tools
Q5M840 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: B921FAB9D9AB709A

FASTA10311,232
        10         20         30         40         50         60 
MESVQELIPL AKEMMTQKSR GKLVKLYVLG SVLAFFGVVL GLVETVCSPF TAASRLRDQE 

        70         80         90        100 
AAVAELRDAC EQQSLHKQAL IAEGKTQEAT LCSRALSLRQ HAS 

« Hide

References

[1]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH473985 Genomic DNA. Translation: EDL95033.1.
BC088248 mRNA. Translation: AAH88248.1.
RefSeqNP_001009632.1. NM_001009632.1.
UniGeneRn.1040.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000007879.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000007879; ENSRNOP00000007879; ENSRNOG00000006019.
GeneID289388.
KEGGrno:289388.

Organism-specific databases

CTD50486.
RGD1311675. G0s2.

Phylogenomic databases

eggNOGNOG45933.
GeneTreeENSGT00390000005294.
HOGENOMHOG000112682.
HOVERGENHBG004465.
InParanoidQ5M840.
OMAKELMAHK.
OrthoDBEOG7FBRMG.
PhylomeDBQ5M840.
TreeFamTF336218.

Gene expression databases

GenevestigatorQ5M840.

Family and domain databases

InterProIPR016821. G0S2.
[Graphical view]
PfamPF15103. G0-G1_switch_2. 1 hit.
[Graphical view]
PIRSFPIRSF023925. G0/G1_switch_p2. 1 hit.
ProtoNetSearch...

Other

NextBio629752.
PROQ5M840.

Entry information

Entry nameG0S2_RAT
AccessionPrimary (citable) accession number: Q5M840
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program