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Protein

G0/G1 switch protein 2

Gene

G0s2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
G0/G1 switch protein 2
Alternative name(s):
G0S2-like protein
Gene namesi
Name:G0s2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1311675. G0s2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 103103G0/G1 switch protein 2PRO_0000416594Add
BLAST

Expressioni

Gene expression databases

GenevisibleiQ5M840. RN.

Interactioni

Subunit structurei

Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007879.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG45933.
GeneTreeiENSGT00390000005294.
HOGENOMiHOG000112682.
HOVERGENiHBG004465.
InParanoidiQ5M840.
OMAiKELMAHK.
OrthoDBiEOG7FBRMG.
PhylomeDBiQ5M840.
TreeFamiTF336218.

Family and domain databases

InterProiIPR016821. G0S2.
[Graphical view]
PfamiPF15103. G0-G1_switch_2. 1 hit.
[Graphical view]
PIRSFiPIRSF023925. G0/G1_switch_p2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5M840-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESVQELIPL AKEMMTQKSR GKLVKLYVLG SVLAFFGVVL GLVETVCSPF
60 70 80 90 100
TAASRLRDQE AAVAELRDAC EQQSLHKQAL IAEGKTQEAT LCSRALSLRQ

HAS
Length:103
Mass (Da):11,232
Last modified:February 1, 2005 - v1
Checksum:iB921FAB9D9AB709A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473985 Genomic DNA. Translation: EDL95033.1.
BC088248 mRNA. Translation: AAH88248.1.
RefSeqiNP_001009632.1. NM_001009632.1.
UniGeneiRn.1040.

Genome annotation databases

EnsembliENSRNOT00000007879; ENSRNOP00000007879; ENSRNOG00000006019.
GeneIDi289388.
KEGGirno:289388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473985 Genomic DNA. Translation: EDL95033.1.
BC088248 mRNA. Translation: AAH88248.1.
RefSeqiNP_001009632.1. NM_001009632.1.
UniGeneiRn.1040.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007879.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007879; ENSRNOP00000007879; ENSRNOG00000006019.
GeneIDi289388.
KEGGirno:289388.

Organism-specific databases

CTDi50486.
RGDi1311675. G0s2.

Phylogenomic databases

eggNOGiNOG45933.
GeneTreeiENSGT00390000005294.
HOGENOMiHOG000112682.
HOVERGENiHBG004465.
InParanoidiQ5M840.
OMAiKELMAHK.
OrthoDBiEOG7FBRMG.
PhylomeDBiQ5M840.
TreeFamiTF336218.

Miscellaneous databases

NextBioi629752.
PROiQ5M840.

Gene expression databases

GenevisibleiQ5M840. RN.

Family and domain databases

InterProiIPR016821. G0S2.
[Graphical view]
PfamiPF15103. G0-G1_switch_2. 1 hit.
[Graphical view]
PIRSFiPIRSF023925. G0/G1_switch_p2. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiG0S2_RAT
AccessioniPrimary (citable) accession number: Q5M840
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: February 1, 2005
Last modified: June 24, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.