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Protein

SHC-transforming protein 1

Gene

Shc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity).By similarity

GO - Molecular functioni

  1. epidermal growth factor receptor binding Source: BHF-UCL
  2. phosphoprotein binding Source: RGD
  3. phosphotyrosine binding Source: RGD
  4. protein complex binding Source: RGD
  5. protein kinase binding Source: GO_Central
  6. protein phosphatase 2A binding Source: RGD
  7. receptor tyrosine kinase binding Source: UniProtKB

GO - Biological processi

  1. actin cytoskeleton organization Source: RGD
  2. activation of MAPK activity Source: RGD
  3. aging Source: RGD
  4. angiogenesis Source: UniProtKB-KW
  5. cellular response to insulin stimulus Source: RGD
  6. epidermal growth factor receptor signaling pathway Source: GO_Central
  7. insulin receptor signaling pathway Source: BHF-UCL
  8. intracellular signal transduction Source: InterPro
  9. neuron differentiation Source: RGD
  10. neuron projection development Source: RGD
  11. organ regeneration Source: RGD
  12. positive regulation of DNA replication Source: BHF-UCL
  13. positive regulation of smooth muscle cell proliferation Source: RGD
  14. positive regulation of vasoconstriction Source: RGD
  15. regulation of growth Source: UniProtKB-KW
  16. response to glucocorticoid Source: RGD
  17. response to hydrogen peroxide Source: RGD
  18. response to hypoxia Source: RGD
  19. response to insulin Source: RGD
  20. response to nicotine Source: RGD
  21. response to organic cyclic compound Source: RGD
  22. response to toxic substance Source: RGD
Complete GO annotation...

Keywords - Biological processi

Angiogenesis, Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SHC-transforming protein 1
Alternative name(s):
Src homology 2 domain-containing-transforming protein C1
Short name:
SH2 domain protein C1
Gene namesi
Name:Shc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620446. Shc1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. endosome membrane Source: RGD
  3. nucleus Source: RGD
  4. plasma membrane Source: RGD
  5. Shc-EGFR complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469SHC-transforming protein 1PRO_0000327222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291PhosphoserineBy similarity
Modified residuei44 – 441N6-acetyllysineBy similarity
Modified residuei239 – 2391PhosphotyrosineBy similarity
Modified residuei240 – 2401PhosphotyrosineBy similarity
Modified residuei312 – 3121PhosphoserineBy similarity
Modified residuei313 – 3131PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to KIT signaling. Tyrosine phosphorylated in response to FLT3 signaling and by ligand-activated ALK. Tyrosine phosphorylated by TEK/TIE2 (By similarity). Tyrosine phosphorylated by ligand-activated PDGFRB (By similarity). May be tyrosine phosphorylated by activated PTK2/FAK1 (By similarity). Dephosphorylation by PTPN2 may regulate interaction with GRB2 (By similarity). Phosphorylated in response to FLT4 signaling. Tyrosine phosphorylated by activated PTK2B/PYK2.By similarity2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5M824.
PRIDEiQ5M824.

PTM databases

PhosphoSiteiQ5M824.

Expressioni

Gene expression databases

GenevestigatoriQ5M824.

Interactioni

Subunit structurei

Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR in vitro via the PID domain. Once activated, binds to GRB2. Interacts with tyrosine-phosphorylated CD3T and DDR2. Interacts with the N-terminal region of APS. Interacts with phosphorylated LRP1 and IRS4. Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. Interacts with ALK, GAB2, GRB7 and KIT. Interacts with PTPN6/SHP (tyrosine phosphorylated). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2A, SRC, SHC1, GAP43 and CTTN. Interacts with EPHB1 and GRB2; activates the MAPK/ERK cascade to regulate cell migration. Interacts with PDGFRB (tyrosine-phosphorylated). Interacts with ERBB4. Interacts with TEK/TIE2 (tyrosine-phosphorylated). Interacts with PTK2/FAK1 (By similarity). Interacts with FLT4 (tyrosine-phosphorylated). Interacts with the Trk receptors NTRK1, NTRK2 and NTRK3; in a phosphotyrosine-dependent manner.By similarity3 Publications

Protein-protein interaction databases

BioGridi250090. 5 interactions.
IntActiQ5M824. 4 interactions.
STRINGi10116.ENSRNOP00000028038.

Structurei

3D structure databases

ProteinModelPortaliQ5M824.
SMRiQ5M824. Positions 1-207, 366-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 229184PIDPROSITE-ProRule annotationAdd
BLAST
Domaini374 – 46592SH2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni230 – 373144CH1Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi297 – 36064Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 PID domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG315087.
HOGENOMiHOG000231974.
HOVERGENiHBG050121.
InParanoidiQ5M824.
KOiK06279.
PhylomeDBiQ5M824.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR029586. Shc1/ShcA.
[Graphical view]
PANTHERiPTHR10337:SF2. PTHR10337:SF2. 1 hit.
PfamiPF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS01179. PID. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M824-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKLSGGGGR RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV
60 70 80 90 100
SYLVRYMGCV EVLQSMRALD FNTRTQVTRE AISLVCEAVP GAKGAMRRRK
110 120 130 140 150
PCSRPLSSIL GRSNLKFAGM PITLTVSTSS LNLMAADCKQ IIANHHMQSI
160 170 180 190 200
SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV ISTIGQAFEL
210 220 230 240 250
RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEELPDHQYY NDFPGKEPPL
260 270 280 290 300
GGVVDMRLRE GAARPTLPST QMPSHLGATL PIGQHVTGDH EVRKQMLPPP
310 320 330 340 350
PCPGRELFDD PSYVNIQNLD KARQAGGGAG PPNPSVNGSA PRDLFDMKPF
360 370 380 390 400
EDALRVPPAP QSMSMAEQLQ GESWFHGKLS RREAEALLQL NGDFLVREST
410 420 430 440 450
TTPGQYVLTG LQSGQPKHLL LVDPEGVVRT KDHRFESVSH LISYHMDNHL
460
PIISAGSELC LQQPVDRKV
Length:469
Mass (Da):51,503
Last modified:February 1, 2005 - v1
Checksum:i9BFEE9D33E07B3F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088298 mRNA. Translation: AAH88298.1.
RefSeqiNP_445969.2. NM_053517.2.
UniGeneiRn.138818.

Genome annotation databases

GeneIDi85385.
KEGGirno:85385.
UCSCiRGD:620446. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088298 mRNA. Translation: AAH88298.1.
RefSeqiNP_445969.2. NM_053517.2.
UniGeneiRn.138818.

3D structure databases

ProteinModelPortaliQ5M824.
SMRiQ5M824. Positions 1-207, 366-469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250090. 5 interactions.
IntActiQ5M824. 4 interactions.
STRINGi10116.ENSRNOP00000028038.

PTM databases

PhosphoSiteiQ5M824.

Proteomic databases

PaxDbiQ5M824.
PRIDEiQ5M824.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi85385.
KEGGirno:85385.
UCSCiRGD:620446. rat.

Organism-specific databases

CTDi6464.
RGDi620446. Shc1.

Phylogenomic databases

eggNOGiNOG315087.
HOGENOMiHOG000231974.
HOVERGENiHBG050121.
InParanoidiQ5M824.
KOiK06279.
PhylomeDBiQ5M824.

Miscellaneous databases

NextBioi617490.
PROiQ5M824.

Gene expression databases

GenevestigatoriQ5M824.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR029586. Shc1/ShcA.
[Graphical view]
PANTHERiPTHR10337:SF2. PTHR10337:SF2. 1 hit.
PfamiPF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS01179. PID. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  2. "Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions."
    Lev S., Moreno H., Martinez R., Canoll P., Peles E., Musacchio J.M., Plowman G.D., Rudy B., Schlessinger J.
    Nature 376:737-745(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
    Tissue: Brain.
  3. "Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor."
    Fournier E., Dubreuil P., Birnbaum D., Borg J.P.
    Oncogene 11:921-931(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, INTERACTION WITH FLT4.
  4. "Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction."
    McCarty J.H., Feinstein S.C.
    Oncogene 16:1691-1700(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NTRK2.
  5. "Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation."
    Yang K., Kim J.H., Kim H.J., Park I.S., Kim I.Y., Yang B.S.
    J. Biol. Chem. 280:39058-39066(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DDR2.

Entry informationi

Entry nameiSHC1_RAT
AccessioniPrimary (citable) accession number: Q5M824
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: February 1, 2005
Last modified: February 4, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.