Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5M824

- SHC1_RAT

UniProt

Q5M824 - SHC1_RAT

Protein

SHC-transforming protein 1

Gene

Shc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis By similarity.By similarity

    GO - Molecular functioni

    1. epidermal growth factor receptor binding Source: BHF-UCL
    2. phosphoprotein binding Source: RGD
    3. phosphotyrosine binding Source: RGD
    4. protein binding Source: RGD
    5. protein complex binding Source: RGD
    6. receptor tyrosine kinase binding Source: UniProtKB

    GO - Biological processi

    1. actin cytoskeleton organization Source: RGD
    2. activation of MAPK activity Source: RGD
    3. aging Source: RGD
    4. angiogenesis Source: UniProtKB-KW
    5. insulin receptor signaling pathway Source: BHF-UCL
    6. intracellular signal transduction Source: InterPro
    7. neuron differentiation Source: RGD
    8. neuron projection development Source: RGD
    9. organ regeneration Source: RGD
    10. positive regulation of DNA replication Source: BHF-UCL
    11. positive regulation of smooth muscle cell proliferation Source: RGD
    12. positive regulation of vasoconstriction Source: RGD
    13. regulation of growth Source: UniProtKB-KW
    14. response to glucocorticoid Source: RGD
    15. response to hydrogen peroxide Source: RGD
    16. response to hypoxia Source: RGD
    17. response to insulin Source: RGD
    18. response to nicotine Source: RGD
    19. response to organic cyclic compound Source: RGD
    20. response to toxic substance Source: RGD

    Keywords - Biological processi

    Angiogenesis, Growth regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SHC-transforming protein 1
    Alternative name(s):
    Src homology 2 domain-containing-transforming protein C1
    Short name:
    SH2 domain protein C1
    Gene namesi
    Name:Shc1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620446. Shc1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. endosome membrane Source: RGD
    3. nucleus Source: RGD
    4. plasma membrane Source: RGD
    5. Shc-EGFR complex Source: BHF-UCL

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 469469SHC-transforming protein 1PRO_0000327222Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei29 – 291PhosphoserineBy similarity
    Modified residuei44 – 441N6-acetyllysineBy similarity
    Modified residuei239 – 2391PhosphotyrosineBy similarity
    Modified residuei240 – 2401PhosphotyrosineBy similarity
    Modified residuei312 – 3121PhosphoserineBy similarity
    Modified residuei313 – 3131PhosphotyrosineBy similarity

    Post-translational modificationi

    Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to KIT signaling. Tyrosine phosphorylated in response to FLT3 signaling and by ligand-activated ALK. Tyrosine phosphorylated by TEK/TIE2 By similarity. Tyrosine phosphorylated by ligand-activated PDGFRB By similarity. May be tyrosine phosphorylated by activated PTK2/FAK1 By similarity. Dephosphorylation by PTPN2 may regulate interaction with GRB2 By similarity. Phosphorylated in response to FLT4 signaling. Tyrosine phosphorylated by activated PTK2B/PYK2.By similarity2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ5M824.
    PRIDEiQ5M824.

    PTM databases

    PhosphoSiteiQ5M824.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5M824.

    Interactioni

    Subunit structurei

    Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR in vitro via the PID domain. Once activated, binds to GRB2. Interacts with tyrosine-phosphorylated CD3T and DDR2. Interacts with the N-terminal region of APS. Interacts with phosphorylated LRP1 and IRS4. Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. Interacts with ALK, GAB2, GRB7 and KIT. Interacts with PTPN6/SHP (tyrosine phosphorylated). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2A, SRC, SHC1, GAP43 and CTTN. Interacts with EPHB1 and GRB2; activates the MAPK/ERK cascade to regulate cell migration. Interacts with PDGFRB (tyrosine-phosphorylated). Interacts with ERBB4. Interacts with TEK/TIE2 (tyrosine-phosphorylated). Interacts with PTK2/FAK1 By similarity. Interacts with FLT4 (tyrosine-phosphorylated). Interacts with the Trk receptors NTRK1, NTRK2 and NTRK3; in a phosphotyrosine-dependent manner.By similarity3 Publications

    Protein-protein interaction databases

    BioGridi250090. 5 interactions.
    IntActiQ5M824. 4 interactions.
    STRINGi10116.ENSRNOP00000028038.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5M824.
    SMRiQ5M824. Positions 1-207, 366-469.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 229184PIDPROSITE-ProRule annotationAdd
    BLAST
    Domaini374 – 46592SH2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni230 – 373144CH1Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi297 – 36064Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PID domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG315087.
    HOGENOMiHOG000231974.
    HOVERGENiHBG050121.
    InParanoidiQ5M824.
    KOiK06279.
    PhylomeDBiQ5M824.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011993. PH_like_dom.
    IPR006019. PID_Shc-like.
    IPR006020. PTB/PI_dom.
    IPR000980. SH2.
    [Graphical view]
    PfamiPF00640. PID. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00629. SHCPIDOMAIN.
    SMARTiSM00462. PTB. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    PROSITEiPS01179. PID. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5M824-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKLSGGGGR RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV    50
    SYLVRYMGCV EVLQSMRALD FNTRTQVTRE AISLVCEAVP GAKGAMRRRK 100
    PCSRPLSSIL GRSNLKFAGM PITLTVSTSS LNLMAADCKQ IIANHHMQSI 150
    SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV ISTIGQAFEL 200
    RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEELPDHQYY NDFPGKEPPL 250
    GGVVDMRLRE GAARPTLPST QMPSHLGATL PIGQHVTGDH EVRKQMLPPP 300
    PCPGRELFDD PSYVNIQNLD KARQAGGGAG PPNPSVNGSA PRDLFDMKPF 350
    EDALRVPPAP QSMSMAEQLQ GESWFHGKLS RREAEALLQL NGDFLVREST 400
    TTPGQYVLTG LQSGQPKHLL LVDPEGVVRT KDHRFESVSH LISYHMDNHL 450
    PIISAGSELC LQQPVDRKV 469
    Length:469
    Mass (Da):51,503
    Last modified:February 1, 2005 - v1
    Checksum:i9BFEE9D33E07B3F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC088298 mRNA. Translation: AAH88298.1.
    RefSeqiNP_445969.2. NM_053517.2.
    UniGeneiRn.138818.

    Genome annotation databases

    GeneIDi85385.
    KEGGirno:85385.
    UCSCiRGD:620446. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC088298 mRNA. Translation: AAH88298.1 .
    RefSeqi NP_445969.2. NM_053517.2.
    UniGenei Rn.138818.

    3D structure databases

    ProteinModelPortali Q5M824.
    SMRi Q5M824. Positions 1-207, 366-469.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 250090. 5 interactions.
    IntActi Q5M824. 4 interactions.
    STRINGi 10116.ENSRNOP00000028038.

    PTM databases

    PhosphoSitei Q5M824.

    Proteomic databases

    PaxDbi Q5M824.
    PRIDEi Q5M824.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 85385.
    KEGGi rno:85385.
    UCSCi RGD:620446. rat.

    Organism-specific databases

    CTDi 6464.
    RGDi 620446. Shc1.

    Phylogenomic databases

    eggNOGi NOG315087.
    HOGENOMi HOG000231974.
    HOVERGENi HBG050121.
    InParanoidi Q5M824.
    KOi K06279.
    PhylomeDBi Q5M824.

    Miscellaneous databases

    NextBioi 617490.
    PROi Q5M824.

    Gene expression databases

    Genevestigatori Q5M824.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011993. PH_like_dom.
    IPR006019. PID_Shc-like.
    IPR006020. PTB/PI_dom.
    IPR000980. SH2.
    [Graphical view ]
    Pfami PF00640. PID. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00629. SHCPIDOMAIN.
    SMARTi SM00462. PTB. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    PROSITEi PS01179. PID. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    2. "Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions."
      Lev S., Moreno H., Martinez R., Canoll P., Peles E., Musacchio J.M., Plowman G.D., Rudy B., Schlessinger J.
      Nature 376:737-745(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION.
      Tissue: Brain.
    3. "Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor."
      Fournier E., Dubreuil P., Birnbaum D., Borg J.P.
      Oncogene 11:921-931(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, INTERACTION WITH FLT4.
    4. "Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction."
      McCarty J.H., Feinstein S.C.
      Oncogene 16:1691-1700(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NTRK2.
    5. "Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation."
      Yang K., Kim J.H., Kim H.J., Park I.S., Kim I.Y., Yang B.S.
      J. Biol. Chem. 280:39058-39066(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DDR2.

    Entry informationi

    Entry nameiSHC1_RAT
    AccessioniPrimary (citable) accession number: Q5M824
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3