Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5M821

- PPM1H_RAT

UniProt

Q5M821 - PPM1H_RAT

Protein

Protein phosphatase 1H

Gene

Ppm1h

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (15 May 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1H (EC:3.1.3.16)
    Gene namesi
    Name:Ppm1h
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi1309528. Ppm1h.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513Protein phosphatase 1HPRO_0000286605Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei123 – 1231PhosphoserineBy similarity
    Modified residuei210 – 2101PhosphoserineBy similarity
    Modified residuei220 – 2201PhosphoserineBy similarity
    Modified residuei223 – 2231PhosphothreonineBy similarity
    Modified residuei421 – 4211PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ5M821.
    PRIDEiQ5M821.

    PTM databases

    PhosphoSiteiQ5M821.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5M821.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000005798.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5M821.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini136 – 506371PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00530000063231.
    HOGENOMiHOG000251606.
    HOVERGENiHBG105802.
    InParanoidiQ5M821.
    KOiK17503.
    OMAiERTVYNI.
    OrthoDBiEOG7F511J.
    PhylomeDBiQ5M821.
    TreeFamiTF314700.

    Family and domain databases

    Gene3Di3.60.40.10. 3 hits.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 2 hits.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 4 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Named isoforms=2.

    Isoform 1 (identifier: Q5M821-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLTRVKSAVA NFMGGIMAGS SGSEHGGSGC GGSDLPLRFP YGRPEFLGLS    50
    QDEVECSADH IARPILILKE TRRLPWATGY AEVINAGKST HNEDQASCEV 100
    LTVKKKVGTI TSTPNRNSKR RSSLPNGEGL QLKENSESEG ISCHYWSLFD 150
    GHAGSGAAVV ASRLLQHHIT QQLQDIVEIL KNSAILPPTC LGEEPESTPA 200
    HGRTLTRAAS LRGGVGAPGS PSTPPTRFFT EKKIPHECLV IGALESAFKE 250
    MDLQIERERS AYNISGGCTA LIVVCLLGKL YVANAGDSRA IIIRNGEIIP 300
    MSSEFTPETE RQRLQYLAFM QPHLLGNEFT HLEFPRRVQR KELGKKMLYR 350
    DFNMTGWAYK TIEDDDLKFP LIYGEGKKAR VMATIGVTRG LGDHDLKVHD 400
    SNIYIKPFLS SAPEVRVYDL SKYEHGADDV LILATDGLWD VLSNEEVAEA 450
    ITQFLPNCDP DDPHRYTLAA QDLVMRARGV LKDRGWRISN DRLGSGDDIS 500
    VYVIPLIHGN KLS 513
    Length:513
    Mass (Da):56,380
    Last modified:May 15, 2007 - v2
    Checksum:i4CA4B69E70C106FD
    GO
    Isoform 2 (identifier: Q5M821-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-319: Missing.
         320-357: MQPHLLGNEF...LYRDFNMTGW → MEEFRYKYVP...RKKTASEMIR

    Note: No experimental confirmation available.

    Show »
    Length:194
    Mass (Da):21,848
    Checksum:i4705C49C473B519F
    GO

    Sequence cautioni

    The sequence AAH88307.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 319319Missing in isoform 2. 1 PublicationVSP_025123Add
    BLAST
    Alternative sequencei320 – 35738MQPHL…NMTGW → MEEFRYKYVPWSSEIQQEGG GMRATVSTRKKTASEMIR in isoform 2. 1 PublicationVSP_025124Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03055580 Genomic DNA. No translation available.
    AABR03055960 Genomic DNA. No translation available.
    AABR03056001 Genomic DNA. No translation available.
    AABR03056562 Genomic DNA. No translation available.
    AABR03058099 Genomic DNA. No translation available.
    AABR03058942 Genomic DNA. No translation available.
    BC088307 mRNA. Translation: AAH88307.1. Different initiation.
    RefSeqiNP_001258008.1. NM_001271079.1. [Q5M821-1]
    UniGeneiRn.198204.

    Genome annotation databases

    EnsembliENSRNOT00000005798; ENSRNOP00000005798; ENSRNOG00000004314. [Q5M821-1]
    ENSRNOT00000066381; ENSRNOP00000061506; ENSRNOG00000004314. [Q5M821-2]
    GeneIDi314897.
    KEGGirno:314897.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03055580 Genomic DNA. No translation available.
    AABR03055960 Genomic DNA. No translation available.
    AABR03056001 Genomic DNA. No translation available.
    AABR03056562 Genomic DNA. No translation available.
    AABR03058099 Genomic DNA. No translation available.
    AABR03058942 Genomic DNA. No translation available.
    BC088307 mRNA. Translation: AAH88307.1 . Different initiation.
    RefSeqi NP_001258008.1. NM_001271079.1. [Q5M821-1 ]
    UniGenei Rn.198204.

    3D structure databases

    ProteinModelPortali Q5M821.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000005798.

    PTM databases

    PhosphoSitei Q5M821.

    Proteomic databases

    PaxDbi Q5M821.
    PRIDEi Q5M821.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000005798 ; ENSRNOP00000005798 ; ENSRNOG00000004314 . [Q5M821-1 ]
    ENSRNOT00000066381 ; ENSRNOP00000061506 ; ENSRNOG00000004314 . [Q5M821-2 ]
    GeneIDi 314897.
    KEGGi rno:314897.

    Organism-specific databases

    CTDi 57460.
    RGDi 1309528. Ppm1h.

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00530000063231.
    HOGENOMi HOG000251606.
    HOVERGENi HBG105802.
    InParanoidi Q5M821.
    KOi K17503.
    OMAi ERTVYNI.
    OrthoDBi EOG7F511J.
    PhylomeDBi Q5M821.
    TreeFami TF314700.

    Miscellaneous databases

    NextBioi 668355.
    PROi Q5M821.

    Gene expression databases

    Genevestigatori Q5M821.

    Family and domain databases

    Gene3Di 3.60.40.10. 3 hits.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 2 hits.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 4 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Liver.

    Entry informationi

    Entry nameiPPM1H_RAT
    AccessioniPrimary (citable) accession number: Q5M821
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3