Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein phosphatase 1H

Gene

Ppm1h

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1H (EC:3.1.3.16)
Gene namesi
Name:Ppm1h
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1309528. Ppm1h.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002866051 – 513Protein phosphatase 1HAdd BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineBy similarity1
Modified residuei113PhosphothreonineCombined sources1
Modified residuei123PhosphoserineBy similarity1
Modified residuei210PhosphoserineBy similarity1
Modified residuei212Omega-N-methylarginineBy similarity1
Modified residuei220PhosphoserineBy similarity1
Modified residuei223PhosphothreonineBy similarity1
Modified residuei421PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ5M821.
PRIDEiQ5M821.

PTM databases

iPTMnetiQ5M821.
PhosphoSitePlusiQ5M821.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004314.
ExpressionAtlasiQ5M821. baseline and differential.
GenevisibleiQ5M821. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005798.

Structurei

3D structure databases

ProteinModelPortaliQ5M821.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 506PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST430

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1323. Eukaryota.
ENOG410XP4B. LUCA.
GeneTreeiENSGT00530000063231.
HOGENOMiHOG000251606.
HOVERGENiHBG105802.
InParanoidiQ5M821.
KOiK17503.
OMAiFQRRVTK.
OrthoDBiEOG091G05FH.
PhylomeDBiQ5M821.
TreeFamiTF314700.

Family and domain databases

Gene3Di3.60.40.10. 3 hits.
InterProiIPR015655. PP2C.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 4 hits.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 4 hits.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Named isoforms=2.
Isoform 1 (identifier: Q5M821-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTRVKSAVA NFMGGIMAGS SGSEHGGSGC GGSDLPLRFP YGRPEFLGLS
60 70 80 90 100
QDEVECSADH IARPILILKE TRRLPWATGY AEVINAGKST HNEDQASCEV
110 120 130 140 150
LTVKKKVGTI TSTPNRNSKR RSSLPNGEGL QLKENSESEG ISCHYWSLFD
160 170 180 190 200
GHAGSGAAVV ASRLLQHHIT QQLQDIVEIL KNSAILPPTC LGEEPESTPA
210 220 230 240 250
HGRTLTRAAS LRGGVGAPGS PSTPPTRFFT EKKIPHECLV IGALESAFKE
260 270 280 290 300
MDLQIERERS AYNISGGCTA LIVVCLLGKL YVANAGDSRA IIIRNGEIIP
310 320 330 340 350
MSSEFTPETE RQRLQYLAFM QPHLLGNEFT HLEFPRRVQR KELGKKMLYR
360 370 380 390 400
DFNMTGWAYK TIEDDDLKFP LIYGEGKKAR VMATIGVTRG LGDHDLKVHD
410 420 430 440 450
SNIYIKPFLS SAPEVRVYDL SKYEHGADDV LILATDGLWD VLSNEEVAEA
460 470 480 490 500
ITQFLPNCDP DDPHRYTLAA QDLVMRARGV LKDRGWRISN DRLGSGDDIS
510
VYVIPLIHGN KLS
Length:513
Mass (Da):56,380
Last modified:May 15, 2007 - v2
Checksum:i4CA4B69E70C106FD
GO
Isoform 2 (identifier: Q5M821-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-319: Missing.
     320-357: MQPHLLGNEF...LYRDFNMTGW → MEEFRYKYVP...RKKTASEMIR

Note: No experimental confirmation available.
Show »
Length:194
Mass (Da):21,848
Checksum:i4705C49C473B519F
GO

Sequence cautioni

The sequence AAH88307 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0251231 – 319Missing in isoform 2. 1 PublicationAdd BLAST319
Alternative sequenceiVSP_025124320 – 357MQPHL…NMTGW → MEEFRYKYVPWSSEIQQEGG GMRATVSTRKKTASEMIR in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03055580 Genomic DNA. No translation available.
AABR03055960 Genomic DNA. No translation available.
AABR03056001 Genomic DNA. No translation available.
AABR03056562 Genomic DNA. No translation available.
AABR03058099 Genomic DNA. No translation available.
AABR03058942 Genomic DNA. No translation available.
BC088307 mRNA. Translation: AAH88307.1. Different initiation.
RefSeqiNP_001258008.1. NM_001271079.2. [Q5M821-1]
UniGeneiRn.198204.

Genome annotation databases

EnsembliENSRNOT00000005798; ENSRNOP00000005798; ENSRNOG00000004314. [Q5M821-1]
GeneIDi314897.
KEGGirno:314897.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03055580 Genomic DNA. No translation available.
AABR03055960 Genomic DNA. No translation available.
AABR03056001 Genomic DNA. No translation available.
AABR03056562 Genomic DNA. No translation available.
AABR03058099 Genomic DNA. No translation available.
AABR03058942 Genomic DNA. No translation available.
BC088307 mRNA. Translation: AAH88307.1. Different initiation.
RefSeqiNP_001258008.1. NM_001271079.2. [Q5M821-1]
UniGeneiRn.198204.

3D structure databases

ProteinModelPortaliQ5M821.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005798.

PTM databases

iPTMnetiQ5M821.
PhosphoSitePlusiQ5M821.

Proteomic databases

PaxDbiQ5M821.
PRIDEiQ5M821.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005798; ENSRNOP00000005798; ENSRNOG00000004314. [Q5M821-1]
GeneIDi314897.
KEGGirno:314897.

Organism-specific databases

CTDi57460.
RGDi1309528. Ppm1h.

Phylogenomic databases

eggNOGiKOG1323. Eukaryota.
ENOG410XP4B. LUCA.
GeneTreeiENSGT00530000063231.
HOGENOMiHOG000251606.
HOVERGENiHBG105802.
InParanoidiQ5M821.
KOiK17503.
OMAiFQRRVTK.
OrthoDBiEOG091G05FH.
PhylomeDBiQ5M821.
TreeFamiTF314700.

Miscellaneous databases

PROiQ5M821.

Gene expression databases

BgeeiENSRNOG00000004314.
ExpressionAtlasiQ5M821. baseline and differential.
GenevisibleiQ5M821. RN.

Family and domain databases

Gene3Di3.60.40.10. 3 hits.
InterProiIPR015655. PP2C.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 4 hits.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 4 hits.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPM1H_RAT
AccessioniPrimary (citable) accession number: Q5M821
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 2, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.