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Q5M821

- PPM1H_RAT

UniProt

Q5M821 - PPM1H_RAT

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Protein

Protein phosphatase 1H

Gene

Ppm1h

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1H (EC:3.1.3.16)
Gene namesi
Name:Ppm1h
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi1309528. Ppm1h.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Protein phosphatase 1HPRO_0000286605Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei123 – 1231PhosphoserineBy similarity
Modified residuei210 – 2101PhosphoserineBy similarity
Modified residuei220 – 2201PhosphoserineBy similarity
Modified residuei223 – 2231PhosphothreonineBy similarity
Modified residuei421 – 4211PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5M821.
PRIDEiQ5M821.

PTM databases

PhosphoSiteiQ5M821.

Expressioni

Gene expression databases

GenevestigatoriQ5M821.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005798.

Structurei

3D structure databases

ProteinModelPortaliQ5M821.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini136 – 506371PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00530000063231.
HOGENOMiHOG000251606.
HOVERGENiHBG105802.
InParanoidiQ5M821.
KOiK17503.
OMAiERTVYNI.
OrthoDBiEOG7F511J.
PhylomeDBiQ5M821.
TreeFamiTF314700.

Family and domain databases

Gene3Di3.60.40.10. 3 hits.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 4 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Named isoforms=2.

Isoform 1 (identifier: Q5M821-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTRVKSAVA NFMGGIMAGS SGSEHGGSGC GGSDLPLRFP YGRPEFLGLS
60 70 80 90 100
QDEVECSADH IARPILILKE TRRLPWATGY AEVINAGKST HNEDQASCEV
110 120 130 140 150
LTVKKKVGTI TSTPNRNSKR RSSLPNGEGL QLKENSESEG ISCHYWSLFD
160 170 180 190 200
GHAGSGAAVV ASRLLQHHIT QQLQDIVEIL KNSAILPPTC LGEEPESTPA
210 220 230 240 250
HGRTLTRAAS LRGGVGAPGS PSTPPTRFFT EKKIPHECLV IGALESAFKE
260 270 280 290 300
MDLQIERERS AYNISGGCTA LIVVCLLGKL YVANAGDSRA IIIRNGEIIP
310 320 330 340 350
MSSEFTPETE RQRLQYLAFM QPHLLGNEFT HLEFPRRVQR KELGKKMLYR
360 370 380 390 400
DFNMTGWAYK TIEDDDLKFP LIYGEGKKAR VMATIGVTRG LGDHDLKVHD
410 420 430 440 450
SNIYIKPFLS SAPEVRVYDL SKYEHGADDV LILATDGLWD VLSNEEVAEA
460 470 480 490 500
ITQFLPNCDP DDPHRYTLAA QDLVMRARGV LKDRGWRISN DRLGSGDDIS
510
VYVIPLIHGN KLS
Length:513
Mass (Da):56,380
Last modified:May 15, 2007 - v2
Checksum:i4CA4B69E70C106FD
GO
Isoform 2 (identifier: Q5M821-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-319: Missing.
     320-357: MQPHLLGNEF...LYRDFNMTGW → MEEFRYKYVP...RKKTASEMIR

Note: No experimental confirmation available.

Show »
Length:194
Mass (Da):21,848
Checksum:i4705C49C473B519F
GO

Sequence cautioni

The sequence AAH88307.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 319319Missing in isoform 2. 1 PublicationVSP_025123Add
BLAST
Alternative sequencei320 – 35738MQPHL…NMTGW → MEEFRYKYVPWSSEIQQEGG GMRATVSTRKKTASEMIR in isoform 2. 1 PublicationVSP_025124Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03055580 Genomic DNA. No translation available.
AABR03055960 Genomic DNA. No translation available.
AABR03056001 Genomic DNA. No translation available.
AABR03056562 Genomic DNA. No translation available.
AABR03058099 Genomic DNA. No translation available.
AABR03058942 Genomic DNA. No translation available.
BC088307 mRNA. Translation: AAH88307.1. Different initiation.
RefSeqiNP_001258008.1. NM_001271079.2. [Q5M821-1]
UniGeneiRn.198204.

Genome annotation databases

EnsembliENSRNOT00000005798; ENSRNOP00000005798; ENSRNOG00000004314. [Q5M821-1]
ENSRNOT00000066381; ENSRNOP00000061506; ENSRNOG00000004314. [Q5M821-2]
GeneIDi314897.
KEGGirno:314897.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03055580 Genomic DNA. No translation available.
AABR03055960 Genomic DNA. No translation available.
AABR03056001 Genomic DNA. No translation available.
AABR03056562 Genomic DNA. No translation available.
AABR03058099 Genomic DNA. No translation available.
AABR03058942 Genomic DNA. No translation available.
BC088307 mRNA. Translation: AAH88307.1 . Different initiation.
RefSeqi NP_001258008.1. NM_001271079.2. [Q5M821-1 ]
UniGenei Rn.198204.

3D structure databases

ProteinModelPortali Q5M821.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000005798.

PTM databases

PhosphoSitei Q5M821.

Proteomic databases

PaxDbi Q5M821.
PRIDEi Q5M821.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000005798 ; ENSRNOP00000005798 ; ENSRNOG00000004314 . [Q5M821-1 ]
ENSRNOT00000066381 ; ENSRNOP00000061506 ; ENSRNOG00000004314 . [Q5M821-2 ]
GeneIDi 314897.
KEGGi rno:314897.

Organism-specific databases

CTDi 57460.
RGDi 1309528. Ppm1h.

Phylogenomic databases

eggNOGi COG0631.
GeneTreei ENSGT00530000063231.
HOGENOMi HOG000251606.
HOVERGENi HBG105802.
InParanoidi Q5M821.
KOi K17503.
OMAi ERTVYNI.
OrthoDBi EOG7F511J.
PhylomeDBi Q5M821.
TreeFami TF314700.

Miscellaneous databases

NextBioi 668355.
PROi Q5M821.

Gene expression databases

Genevestigatori Q5M821.

Family and domain databases

Gene3Di 3.60.40.10. 3 hits.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 2 hits.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 4 hits.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Liver.

Entry informationi

Entry nameiPPM1H_RAT
AccessioniPrimary (citable) accession number: Q5M821
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 26, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3