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Protein

MORF4 family-associated protein 1

Gene

Mrfap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
MORF4 family-associated protein 1
Alternative name(s):
T-cell activation protein-related protein
Gene namesi
Name:Mrfap1Imported
Synonyms:Pgr1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi628631. Mrfap1.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasmperinuclear region By similarity

  • Note: Colocalizes with MORF4L1 to cell nuclei.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 125125MORF4 family-associated protein 1PRO_0000306179Add
BLAST

Proteomic databases

PaxDbiQ5M820.
PRIDEiQ5M820.

PTM databases

PhosphoSiteiQ5M820.

Expressioni

Gene expression databases

GenevisibleiQ5M820. RN.

Interactioni

Subunit structurei

Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2.By similarity1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008121.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili94 – 12431Sequence analysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J03M. Eukaryota.
ENOG4111AYE. LUCA.
GeneTreeiENSGT00510000048749.
HOGENOMiHOG000070216.
HOVERGENiHBG104090.
InParanoidiQ5M820.
OMAiRGTKRCE.
OrthoDBiEOG7K6PXM.

Family and domain databases

InterProiIPR029254. MRFAP1.
[Graphical view]
PfamiPF15155. MRFAP1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q5M820-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPLDAVELA EPEEVEVLEP EEDFEQFLLP VIHEMREDIA SLTRERGRAP
60 70 80 90 100
VRNRGKLWEM DNMLIQIKTQ VEASEESALN HLQGAGGAEP RGPRAEKADE
110 120
KAQEMAKMAE MLVQLVRRIE KSESS
Note: No experimental confirmation available.Curated
Length:125
Mass (Da):14,222
Last modified:February 1, 2005 - v1
Checksum:i7933F06246BD6085
GO
Isoform 21 Publication (identifier: Q5M820-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-41: Missing.

Show »
Length:101
Mass (Da):11,353
Checksum:i822A143636440814
GO

Sequence cautioni

The sequence AAN03958.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei18 – 4124Missing in isoform 2. 1 PublicationVSP_052549Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF526268 mRNA. Translation: AAN03958.1. Different initiation.
BC088308 mRNA. Translation: AAH88308.1.
RefSeqiNP_001009264.1. NM_001009264.1. [Q5M820-1]
UniGeneiRn.3393.

Genome annotation databases

EnsembliENSRNOT00000089759; ENSRNOP00000071505; ENSRNOG00000055319. [Q5M820-1]
GeneIDi282585.
KEGGirno:282585.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF526268 mRNA. Translation: AAN03958.1. Different initiation.
BC088308 mRNA. Translation: AAH88308.1.
RefSeqiNP_001009264.1. NM_001009264.1. [Q5M820-1]
UniGeneiRn.3393.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008121.

PTM databases

PhosphoSiteiQ5M820.

Proteomic databases

PaxDbiQ5M820.
PRIDEiQ5M820.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000089759; ENSRNOP00000071505; ENSRNOG00000055319. [Q5M820-1]
GeneIDi282585.
KEGGirno:282585.

Organism-specific databases

CTDi93621.
RGDi628631. Mrfap1.

Phylogenomic databases

eggNOGiENOG410J03M. Eukaryota.
ENOG4111AYE. LUCA.
GeneTreeiENSGT00510000048749.
HOGENOMiHOG000070216.
HOVERGENiHBG104090.
InParanoidiQ5M820.
OMAiRGTKRCE.
OrthoDBiEOG7K6PXM.

Miscellaneous databases

PROiQ5M820.

Gene expression databases

GenevisibleiQ5M820. RN.

Family and domain databases

InterProiIPR029254. MRFAP1.
[Graphical view]
PfamiPF15155. MRFAP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "New insights into the molecular basis of progressive myoclonus epilepsy: a multiprotein complex with cystatin B."
    Di Giaimo R., Riccio M., Santi S., Galeotti C., Ambrosetti D.C., Melli M.
    Hum. Mol. Genet. 11:2941-2950(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH CSTB.
    Strain: Sprague-DawleyImported.
    Tissue: CerebellumImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: LiverImported.

Entry informationi

Entry nameiMOFA1_RAT
AccessioniPrimary (citable) accession number: Q5M820
Secondary accession number(s): Q8K3W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: February 1, 2005
Last modified: June 8, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.