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Q5M819 (SERB_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoserine phosphatase
Short name=PSP
Short name=PSPase
EC=3.1.3.3
Alternative name(s):
O-phosphoserine phosphohydrolase
Gene names
Name:Psph
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates By similarity.

Catalytic activity

O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Pathway

Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the serB family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 225225Phosphoserine phosphatase
PRO_0000156882

Regions

Region109 – 1102Substrate binding By similarity

Sites

Active site201Nucleophile By similarity
Active site221Proton donor By similarity
Metal binding201Magnesium By similarity
Metal binding221Magnesium; via carbonyl oxygen By similarity
Metal binding1791Magnesium By similarity
Binding site291Substrate By similarity
Binding site651Substrate By similarity
Binding site1581Substrate By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5M819 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: E8FC815C4164391C

FASTA22524,968
        10         20         30         40         50         60 
MVSHSELRKL FCSADAVCFD VDSTVIREEG IDELAKFCGV EAAVSEMTRR AMGGALPFKD 

        70         80         90        100        110        120 
ALTERLALIQ PSRDQVQRLL AEHPPHLTPG IRELVSRLQE RNVQVFLISG GFRSIVEHVA 

       130        140        150        160        170        180 
AKLNIPTTNV FANRLKFYFN GEYAGFDETQ PTAESGGKGK VIGFLKEKFH FKKIIMIGDG 

       190        200        210        220 
ATDMEACPPA DAFIGFGGNV IRQQVKDNAK WYITDFVELL GELEE

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC088310 mRNA. Translation: AAH88310.1.
IPIIPI00188112.
RefSeqNP_001009679.1. NM_001009679.1.
UniGeneRn.8734.

3D structure databases

ProteinModelPortalQ5M819.
SMRQ5M819. Positions 4-225.
ModBaseSearch...

Protein-protein interaction databases

IntActQ5M819. 1 interaction.
STRINGQ5M819.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000001228; ENSRNOP00000001228; ENSRNOG00000000925.
GeneID304429.
KEGGrno:304429.
NMPDRfig|10116.3.peg.8465.
UCSCNM_001009679. rat.

Organism-specific databases

CTD5723.
RGD1308764. Psph.

Phylogenomic databases

eggNOGmaNOG12671.
GeneTreeENSGT00390000003115.
HOVERGENHBG057486.
InParanoidQ5M819.
OMAYAGFDES.
OrthoDBEOG4NVZM5.
PhylomeDBQ5M819.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-10301.

Gene expression databases

ArrayExpressQ5M819.
GenevestigatorQ5M819.
GermOnlineENSRNOG00000000925. Rattus norvegicus.

Family and domain databases

InterProIPR005834. Dehalogen-like_hydro.
IPR023214. HAD-like_dom.
IPR006383. HAD-SF_hydro_IB_PSP-like.
IPR023190. Pser_Pase_dom_2.
IPR004469. SerB.
[Graphical view]
Gene3DG3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
G3DSA:1.10.150.210. Pser_Pase_dom_2. 1 hit.
KOK01079.
PfamPF00702. Hydrolase. 1 hit.
[Graphical view]
SUPFAMSSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01488. HAD-SF-IB. 1 hit.
TIGR00338. SerB. 1 hit.
ProtoNetSearch...

Other

NextBio653036.

Entry information

Entry nameSERB_RAT
AccessionPrimary (citable) accession number: Q5M819
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: February 1, 2005
Last modified: November 16, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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