Reviewed, UniProtKB/Swiss-Prot Q5M819 (SERB_RAT)

Names and origin

Protein names

Recommended name:
    Phosphoserine phosphatase
      Short name=PSPase
      Short name=PSP
    EC=3.1.3.3
Alternative name(s):
    O-phosphoserine phosphohydrolase

Gene names

Name:

Psph

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates By similarity.
Catalytic activity	O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate.
Cofactor	Magnesium By similarity.
Pathway	Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the serB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Serine biosynthesis
Ligand	Magnesium
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	L-serine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW response to mechanical stimulus Inferred from expression pattern. Source: RGD response to nutrient levels Inferred from expression pattern. Source: RGD response to testosterone stimulus Inferred from expression pattern. Source: RGD
Cellular component	synaptosome Inferred from direct assay. Source: RGD
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoserine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	Phosphoserine phosphatase		PRO_0000156882

Sequences

	Sequence		Length	Mass (Da)
	Q5M819-1 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: E8FC815C4164391C	FASTA	225	24,968
	10 20 30 40 50 60 MVSHSELRKL FCSADAVCFD VDSTVIREEG IDELAKFCGV EAAVSEMTRR AMGGALPFKD 70 80 90 100 110 120 ALTERLALIQ PSRDQVQRLL AEHPPHLTPG IRELVSRLQE RNVQVFLISG GFRSIVEHVA 130 140 150 160 170 180 AKLNIPTTNV FANRLKFYFN GEYAGFDETQ PTAESGGKGK VIGFLKEKFH FKKIIMIGDG 190 200 210 220 ATDMEACPPA DAFIGFGGNV IRQQVKDNAK WYITDFVELL GELEE

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC088310 mRNA. Translation: AAH88310.1.
IPI	IPI00188112.
RefSeq	NP_001009679.1.
UniGene	Rn.8734
3D structure databases
SMR	Q5M819. Positions 4-225.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5M819.
Genome annotation databases
Ensembl	ENSRNOT00000001228; ENSRNOP00000001228; ENSRNOG00000000925; Rattus norvegicus. [Genome view]
GeneID	304429.
KEGG	rno:304429.
NMPDR	fig|10116.3.peg.8465.
UCSC	NM_001009679. rat.
Organism-specific databases
CTD	304429.
RGD	1308764. Psph.
Phylogenomic databases
HOVERGEN	Q5M819.
OMA	PATNVFA.
Enzyme and pathway databases
BioCyc	MetaCyc:MON-10301.
BRENDA	3.1.3.3. 248.
Gene expression databases
ArrayExpress	Q5M819.
Genevestigator	Q5M819.
GermOnline	ENSRNOG00000000925. Rattus norvegicus.
Family and domain databases
InterPro	IPR005834. Dehalogen-like_hydro. IPR006383. HAD-SF_hydro_IB_PSP-like. IPR004469. SerB. [Graphical view]
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01488. HAD-SF-IB. 1 hit. TIGR00338. serB. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	653036.

Entry information

Entry name

SERB_RAT

Accession

Primary (citable) accession number: Q5M819

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	February 1, 2005
Last modified:	November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)