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Reviewed, UniProtKB/Swiss-Prot Q5M7W7 (SYPM_RAT)

Last modified October 13, 2009. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Probable prolyl-tRNA synthetase, mitochondrial
    EC=6.1.1.15
Alternative name(s):
    Proline--tRNA ligase
      Short name=ProRS
Gene names
Name: Pars2
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length475 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

Subcellular location

Mitochondrion matrix Potential.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

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Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
Gene Ontology (GO)
   Biological processprolyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

proline-tRNA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2929Mitochondrion Potential
Chain30 – 475446Probable prolyl-tRNA synthetase, mitochondrial
PRO_0000035820

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Sequences

Sequence LengthMass (Da)Tools
Q5M7W7-1 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: DC56602694F0DCC1

FASTA47553,333
        10         20         30         40         50         60 
MEGLLTRCRT LSALATCSLR HSRCIVRKCY HCAPGRGQRL VVSRMFQPQN LREDQVLSLE 

        70         80         90        100        110        120 
GRASDLTCKS QRLMLQVGLI LPASPGCYHL MPYTVRAVEK LVRVIDQEMQ AIGGQKINMP 

       130        140        150        160        170        180 
SLSPAELWRA TGRWDLMGRE LLRLKDRHGK EYCLGPTHEE AVTALVASQK KLSYKQLPLL 

       190        200        210        220        230        240 
LYQVTRKFRD EPRPRFGLLR GREFYMKDMY TFDSSSEAAQ ETYSLVCDAY CRLFDRLGLR 

       250        260        270        280        290        300 
WMKARADVGS IGGTMSHEFQ LPVDIGEDRL VVCPSCHFSA NTEIVDLSQK ICPDCQGPLT 

       310        320        330        340        350        360 
ETKGIEVGHT FYLGTKYSSI FNAHFTNAHG ESLLAEMGCY GLGVTRILAA AIEVLSTEDC 

       370        380        390        400        410        420 
IRWPSLLAPY QVCIIPPKKG SKEAAATEIV ERLYDDVTEA LPQLRGEVLL DDRTHLTIGN 

       430        440        450        460        470 
RLKDANKLGY PFVIIASKRA LEDPAHFEVW SQNTGEVVFL TKEGVMELLT GVHVV

« Hide

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References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

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Cross-references

Sequence databases

BC088403 mRNA. Translation: AAH88403.1.
IPIIPI00358409.
RefSeqNP_001014086.1.
UniGeneRn.205937

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ5M7W7.

Genome annotation databases

EnsemblENSRNOT00000009630; ENSRNOP00000009630; ENSRNOG00000007327; Rattus norvegicus. [Genome view]
ENSRNOT00000057471; ENSRNOP00000054281; ENSRNOG00000007327; Rattus norvegicus. [Genome view]
GeneID313429.
KEGGrno:313429.
NMPDRfig|10116.3.peg.23565.
UCSCNM_001014064. rat.

Organism-specific databases

CTD313429.
RGD1305345. Pars2.

Phylogenomic databases

HOVERGENQ5M7W7.

Enzyme and pathway databases

BRENDA6.1.1.15. 248.

Gene expression databases

ArrayExpressQ5M7W7.
GenevestigatorQ5M7W7.

Family and domain databases

InterProIPR002314. aa-tRNA-synt_IIb_cons-reg.
IPR006195. aa-tRNA-synth_II_cons-reg.
IPR004154. Anticodon_bd.
IPR002316. Pro-tRNA-synth_IIa_cons-reg.
[Graphical view]
Gene3DG3DSA:3.40.50.800. Anticodon_bd. 1 hit.
PfamPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PRINTSPR01046. TRNASYNTHPRO.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio666136.

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Entry information

Entry nameSYPM_RAT
AccessionPrimary (citable) accession number: Q5M7W7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 1, 2005
Last modified: October 13, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents