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Protein

Transmembrane channel-like protein 5

Gene

Tmc5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probable ion channel.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane channel-like protein 5
Gene namesi
Name:Tmc5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1307037. Tmc5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 417417ExtracellularSequence analysisAdd
BLAST
Transmembranei418 – 43821HelicalSequence analysisAdd
BLAST
Topological domaini439 – 4446CytoplasmicSequence analysis
Transmembranei445 – 46723HelicalSequence analysisAdd
BLAST
Topological domaini468 – 48417ExtracellularSequence analysisAdd
BLAST
Transmembranei485 – 50521HelicalSequence analysisAdd
BLAST
Topological domaini506 – 57873CytoplasmicSequence analysisAdd
BLAST
Transmembranei579 – 59921HelicalSequence analysisAdd
BLAST
Topological domaini600 – 61314ExtracellularSequence analysisAdd
BLAST
Transmembranei614 – 63421HelicalSequence analysisAdd
BLAST
Topological domaini635 – 65723CytoplasmicSequence analysisAdd
BLAST
Transmembranei658 – 67821HelicalSequence analysisAdd
BLAST
Topological domaini679 – 69113ExtracellularSequence analysisAdd
BLAST
Transmembranei692 – 71221HelicalSequence analysisAdd
BLAST
Topological domaini713 – 74735CytoplasmicSequence analysisAdd
BLAST
Transmembranei748 – 76821HelicalSequence analysisAdd
BLAST
Topological domaini769 – 79426ExtracellularSequence analysisAdd
BLAST
Transmembranei795 – 81521HelicalSequence analysisAdd
BLAST
Topological domaini816 – 85944CytoplasmicSequence analysisAdd
BLAST
Transmembranei860 – 88021HelicalSequence analysisAdd
BLAST
Topological domaini881 – 96585ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 965965Transmembrane channel-like protein 5PRO_0000289968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei248 – 2481PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5M7W4.
PRIDEiQ5M7W4.

PTM databases

iPTMnetiQ5M7W4.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059631.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH09. Eukaryota.
ENOG410XR0Y. LUCA.
HOGENOMiHOG000154633.
HOVERGENiHBG108587.
InParanoidiQ5M7W4.
PhylomeDBiQ5M7W4.

Family and domain databases

InterProiIPR012496. TMC.
[Graphical view]
PfamiPF07810. TMC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5M7W4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSFHKNSSY MEDPDYPGYS GSQNHTQNYL RTQDDLEFPG CLDNPGFHHP
60 70 80 90 100
RRNPYSSDSR TNPDYHHSLA EPDYPGSPSD ADYQNTRCHP RSAHPRTRPD
110 120 130 140 150
YEPDYEPDYN DFQSESYHPD LSMEPDYPGS HGHPGFAGVR SSVNSTGPRT
160 170 180 190 200
NLGYLDLEEP DYPGAQGNSY HSGPRSHSNL PGSRRNAGYA GSRINSYPDS
210 220 230 240 250
LGEPDYPGAE NQPNSPDFYG KPDYPGAEEG DVYSPSKTLG VIGRSRGSFG
260 270 280 290 300
ILGREDGDYP EGIEMASLGM AGDPRNGYVN PAYMRGSSPV CPDRNLLLCA
310 320 330 340 350
RDWNTSPQGQ KLIASLVPMT SRDRIKTIRN QPRTMQEKRE LRKIVDKEKN
360 370 380 390 400
KQSHGTFEAN CCAQCLSSLS LAYRRTKSSL SELLNYISLW QKRFKVIGGK
410 420 430 440 450
FGTSVLSYFS FLRWLLKFNI FSFVMNFSFI IIPQFTVGEK NTLQFTGLEF
460 470 480 490 500
FTGAGYFRET VMYYGFYTNS TIRHRMGGAS YNMQLAYIFT IGACLVICFF
510 520 530 540 550
SLLFSMAKYF RNNFINPHIY SRGIAKLIFC WDFTVTHEKA VKLKQKNLST
560 570 580 590 600
EIRENLSEIR QENDRLTLNQ KLTRFSVHVA AWLVSTGITA ACCVAVYYLA
610 620 630 640 650
EYNSEFLKTH KNPGAVLLLP FVVSCINLAV PRFYSMFRLV ERYEIPRQEV
660 670 680 690 700
YVLLIRNIFL KISIVGILCY YWLNIVALSG EECWETLIGQ DIYRLLLMDF
710 720 730 740 750
VFSLADSLLG EFLRRLIGMK FITSLSLQEF DIARNVLELI YAQTLAWLGI
760 770 780 790 800
FFCPLLPFIQ MITLFIMFYV KNVSLMMNFQ PPSKAWRASQ MITFFIFLLF
810 820 830 840 850
FPSFTGVLCT LAITIWRLKP SADCGPFRGL PSFIQSIYSW IDTLSHRPGY
860 870 880 890 900
LWVVWIYQNL IGSVHFFFIL TLIVLIITYL YWQITEGRKV MIRLLHEQII
910 920 930 940 950
NEGKDKMFLI EKLTKLQDIE RRANPSTLVL ERREVEQQSP LHLEELDAAP
960
DLRLRRSMQE ENAIA
Note: No experimental confirmation available.
Length:965
Mass (Da):110,718
Last modified:May 29, 2007 - v2
Checksum:iF27C86122F38E7B4
GO
Isoform 2 (identifier: Q5M7W4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-207: Missing.
     208-307: GAENQPNSPD...LCARDWNTSP → MLSDDQVNEI...DEACTFHETV

Show »
Length:758
Mass (Da):87,988
Checksum:i685C0318A6D4BA6D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 207207Missing in isoform 2. 1 PublicationVSP_026049Add
BLAST
Alternative sequencei208 – 307100GAENQ…WNTSP → MLSDDQVNEIIIEVENVPSG VQRNVSSNQITLRKSSAKPN FSMLSSSTADTIDCQIFSHG NDRRHNRLLRFSSLNDSISQ IYHGPECLGMDEACTFHETV in isoform 2. 1 PublicationVSP_026050Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088406 mRNA. Translation: AAH88406.1.
AABR03003518 Genomic DNA. No translation available.
AABR03003346 Genomic DNA. No translation available.
RefSeqiNP_001012216.1. NM_001012216.1. [Q5M7W4-2]
UniGeneiRn.145296.

Genome annotation databases

GeneIDi365360.
KEGGirno:365360.
UCSCiRGD:1307037. rat. [Q5M7W4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088406 mRNA. Translation: AAH88406.1.
AABR03003518 Genomic DNA. No translation available.
AABR03003346 Genomic DNA. No translation available.
RefSeqiNP_001012216.1. NM_001012216.1. [Q5M7W4-2]
UniGeneiRn.145296.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059631.

PTM databases

iPTMnetiQ5M7W4.

Proteomic databases

PaxDbiQ5M7W4.
PRIDEiQ5M7W4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi365360.
KEGGirno:365360.
UCSCiRGD:1307037. rat. [Q5M7W4-1]

Organism-specific databases

CTDi79838.
RGDi1307037. Tmc5.

Phylogenomic databases

eggNOGiENOG410IH09. Eukaryota.
ENOG410XR0Y. LUCA.
HOGENOMiHOG000154633.
HOVERGENiHBG108587.
InParanoidiQ5M7W4.
PhylomeDBiQ5M7W4.

Miscellaneous databases

PROiQ5M7W4.

Family and domain databases

InterProiIPR012496. TMC.
[Graphical view]
PfamiPF07810. TMC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-515.
    Strain: Brown Norway.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTMC5_RAT
AccessioniPrimary (citable) accession number: Q5M7W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: June 8, 2016
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.