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Protein

Thioredoxin-interacting protein

Gene

Txnip

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cellular response to tumor cell Source: UniProtKB
  • keratinocyte differentiation Source: Ensembl
  • negative regulation of cell division Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: Ensembl
  • platelet-derived growth factor receptor signaling pathway Source: Ensembl
  • positive regulation of apoptotic process Source: RGD
  • protein import into nucleus Source: Ensembl
  • regulation of cell proliferation Source: RGD
  • response to calcium ion Source: RGD
  • response to drug Source: RGD
  • response to estradiol Source: RGD
  • response to glucose Source: RGD
  • response to hydrogen peroxide Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to progesterone Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processCell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-844456 The NLRP3 inflammasome

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-interacting protein
Alternative name(s):
Vitamin D3 up-regulated protein 1
Gene namesi
Name:Txnip
Synonyms:Vdup1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620886 Txnip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002504931 – 394Thioredoxin-interacting proteinAdd BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi63InterchainBy similarity
Cross-linki212Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei361PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.By similarity

Keywords - PTMi

Disulfide bond, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5M7W1
PRIDEiQ5M7W1

PTM databases

PhosphoSitePlusiQ5M7W1

Expressioni

Gene expression databases

BgeeiENSRNOG00000021201
GenevisibleiQ5M7W1 RN

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1 (By similarity). Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250736, 1 interactor
IntActiQ5M7W1, 1 interactor
STRINGi10116.ENSRNOP00000028793

Structurei

3D structure databases

ProteinModelPortaliQ5M7W1
SMRiQ5M7W1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

eggNOGiKOG3780 Eukaryota
ENOG41102NY LUCA
GeneTreeiENSGT00550000074356
HOGENOMiHOG000237328
HOVERGENiHBG066469
InParanoidiQ5M7W1
KOiK20910
OMAiISGMCDA
OrthoDBiEOG091G0B0Y
PhylomeDBiQ5M7W1

Family and domain databases

Gene3Di2.60.40.640, 2 hits
InterProiView protein in InterPro
IPR011021 Arrestin-like_N
IPR014752 Arrestin_C
IPR011022 Arrestin_C-like
IPR014756 Ig_E-set
PfamiView protein in Pfam
PF02752 Arrestin_C, 1 hit
PF00339 Arrestin_N, 1 hit
SMARTiView protein in SMART
SM01017 Arrestin_C, 1 hit
SUPFAMiSSF81296 SSF81296, 2 hits

Sequencei

Sequence statusi: Complete.

Q5M7W1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMFKKIKSF EVVFNDPEKV YGSGEKVAGR VTVEVCEVTR VKAVRILACG
60 70 80 90 100
VAKVLWMQGS QQCKQTLDYL RYEDTLLLED QPTGENEMVI MRPGNKYEYK
110 120 130 140 150
FGFELPQGPL GTSFKGKYGC VDYWVKAFLD RPSQPTQEAK KNFEVMDLVD
160 170 180 190 200
VNTPDLMAPV SAKKEKKVSC MFIPDGRVSV SARIDRKGFC EGDDISIHAD
210 220 230 240 250
FENTCSRIVV PKAAIVARHT YLANGQTKVL TQKLSSVRGN HIISGTCASW
260 270 280 290 300
RGKSLRVQKI RPSILGCNIL RVEYSLLIYV SVPGSKKVIL DLPLVIGSRS
310 320 330 340 350
GLSSRTSSMA SRTSSEMSWI DLNIPDTPEA PPCYMDVIPE DHRLESPTTP
360 370 380 390
LLDDVDDSQD SPIFMYAPEF QFMPPPTYTE VDPCVLNNNN NNVQ
Length:394
Mass (Da):44,018
Last modified:February 1, 2005 - v1
Checksum:i6CE164C68D4B0CBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088411 mRNA Translation: AAH88411.1
RefSeqiNP_001008767.1, NM_001008767.1
UniGeneiRn.2758

Genome annotation databases

EnsembliENSRNOT00000028793; ENSRNOP00000028793; ENSRNOG00000021201
GeneIDi117514
KEGGirno:117514
UCSCiRGD:620886 rat

Similar proteinsi

Entry informationi

Entry nameiTXNIP_RAT
AccessioniPrimary (citable) accession number: Q5M7W1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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