Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

FAST kinase domain-containing protein 2, mitochondrial

Gene

Fastkd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in assembly of the mitochondrial large ribosomal subunit.By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular respiration Source: UniProtKB
  • mitochondrial large ribosomal subunit assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
FAST kinase domain-containing protein 2, mitochondrial
Gene namesi
Name:Fastkd2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1307883. Fastkd2.

Subcellular locationi

  • Mitochondrion matrixmitochondrion nucleoid By similarity

  • Note: Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids.By similarity

GO - Cellular componenti

  • mitochondrial nucleoid Source: UniProtKB
  • mitochondrion Source: UniProtKB
  • ribonucleoprotein granule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000050786? – 679FAST kinase domain-containing protein 2, mitochondrial
Transit peptidei1 – ?MitochondrionCurated

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei113PhosphoserineBy similarity1
Modified residuei126PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5M7V7.
PeptideAtlasiQ5M7V7.
PRIDEiQ5M7V7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000023923.
GenevisibleiQ5M7V7. RN.

Interactioni

Subunit structurei

Monomer. Found in a complex with GRSF1, DDX28, DHX30 and FASTKD5. Associates with the 16S mitochondrial rRNA (16S mt-rRNA).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017281.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini607 – 664RAPPROSITE-ProRule annotationAdd BLAST58

Sequence similaritiesi

Belongs to the FAST kinase family.Curated
Contains 1 RAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IH1K. Eukaryota.
ENOG410ZQHV. LUCA.
HOGENOMiHOG000112491.
HOVERGENiHBG081516.
InParanoidiQ5M7V7.
KOiK18190.
OrthoDBiEOG091G0WV6.
PhylomeDBiQ5M7V7.

Family and domain databases

InterProiIPR010622. FAST_Leu-rich.
IPR013584. RAP.
[Graphical view]
PfamiPF06743. FAST_1. 1 hit.
PF08373. RAP. 1 hit.
[Graphical view]
SMARTiSM00952. RAP. 1 hit.
[Graphical view]
PROSITEiPS51286. RAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5M7V7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNRAHTFLW GIRQFRTSIP RSRALRTYSL VFCKPEVIHS KRNPRNHLLN
60 70 80 90 100
GFDEGLQPSV RYLFQDIFIS KSVAGCTQTR GIIHAAGFKL DRILCPRRLS
110 120 130 140 150
FDAKHSFVSD GTSDHDLMKT NFHHTSTEDV LTKKMRPTPV NYKKLAQECN
160 170 180 190 200
SLSDVLDTFS KAPTFPGSNY FLAMWIIAKR ISEDKRRFEK QLMFSHPAFN
210 220 230 240 250
QLCEQMMREA KIMRYDHLLF SLNAIVKLGV PQNSLMVQTL LRTIQERISE
260 270 280 290 300
CDERCLSILS TALVTMEPCM NVNALRAGLR ILVDQQVWNI NDIFTLQTVM
310 320 330 340 350
RCIGKDMKAL KELGRFSVLN SRHMFEVLAA MDHRSVVLLN ECSKIVIDNI
360 370 380 390 400
HGCPFKVLIS ILQSCRDLRY QNEDLFKSIA DYVATTFDIW KLKHVIFFLL
410 420 430 440 450
SFETLGFRPP GLMDKLLEKV VQEPGSLTVK NIVSVLHVYS SLNHVHNVQN
460 470 480 490 500
REFLEALASA LTGCLHQISS ESLLNAVHSF CMMNYFPLAP INQLIKENII
510 520 530 540 550
HELLTSGDTE KNIHKLHVLN TCLKLDESTY KCIHIPLPQL PLTASHPNEK
560 570 580 590 600
LAEVLSRLLE GDGCFSRNVQ LPHNYHIDFE IRMDTNRTQV FSFSEGDASS
610 620 630 640 650
ATNMQRVAVL CVPKSAYCLN SNHLRGLMAM KIRHLNVMGF HVILIHNWEL
660 670
KKLKMEDAVT FVRKKIYSDE ALATTDESV
Length:679
Mass (Da):77,767
Last modified:February 1, 2005 - v1
Checksum:i643E7B03953FDF4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088416 mRNA. Translation: AAH88416.1.
RefSeqiNP_001009673.1. NM_001009673.1.
UniGeneiRn.24905.

Genome annotation databases

GeneIDi301463.
KEGGirno:301463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088416 mRNA. Translation: AAH88416.1.
RefSeqiNP_001009673.1. NM_001009673.1.
UniGeneiRn.24905.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017281.

Proteomic databases

PaxDbiQ5M7V7.
PeptideAtlasiQ5M7V7.
PRIDEiQ5M7V7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi301463.
KEGGirno:301463.

Organism-specific databases

CTDi22868.
RGDi1307883. Fastkd2.

Phylogenomic databases

eggNOGiENOG410IH1K. Eukaryota.
ENOG410ZQHV. LUCA.
HOGENOMiHOG000112491.
HOVERGENiHBG081516.
InParanoidiQ5M7V7.
KOiK18190.
OrthoDBiEOG091G0WV6.
PhylomeDBiQ5M7V7.

Miscellaneous databases

PROiQ5M7V7.

Gene expression databases

BgeeiENSRNOG00000023923.
GenevisibleiQ5M7V7. RN.

Family and domain databases

InterProiIPR010622. FAST_Leu-rich.
IPR013584. RAP.
[Graphical view]
PfamiPF06743. FAST_1. 1 hit.
PF08373. RAP. 1 hit.
[Graphical view]
SMARTiSM00952. RAP. 1 hit.
[Graphical view]
PROSITEiPS51286. RAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFAKD2_RAT
AccessioniPrimary (citable) accession number: Q5M7V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 1, 2005
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.