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Protein

Actin-related protein 2

Gene

Actr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi160 – 162ATPBy similarity3
Nucleotide bindingi214 – 218ATPBy similarity5
Nucleotide bindingi305 – 310ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

  • Arp2/3 complex-mediated actin nucleation Source: Ensembl
  • associative learning Source: RGD
  • asymmetric cell division Source: Ensembl
  • cellular response to interferon-gamma Source: Ensembl
  • cellular response to trichostatin A Source: RGD
  • cilium assembly Source: Ensembl
  • cytosolic transport Source: Ensembl
  • establishment or maintenance of cell polarity Source: Ensembl
  • meiotic chromosome movement towards spindle pole Source: Ensembl
  • meiotic cytokinesis Source: Ensembl
  • positive regulation of dendritic spine morphogenesis Source: RGD
  • response to ethanol Source: RGD
  • response to immobilization stress Source: RGD
  • spindle localization Source: Ensembl

Keywordsi

Molecular functionActin-binding
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-2029482 Regulation of actin dynamics for phagocytic cup formation
R-RNO-3928662 EPHB-mediated forward signaling
R-RNO-5663213 RHO GTPases Activate WASPs and WAVEs
R-RNO-6798695 Neutrophil degranulation
R-RNO-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2
Alternative name(s):
Actin-like protein 2
Gene namesi
Name:Actr2
Synonyms:Arp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1310826 Actr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000890701 – 394Actin-related protein 2Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei299N6-acetyllysineBy similarity1
Modified residuei322N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5M7U6
PRIDEiQ5M7U6

2D gel databases

World-2DPAGEi0004:Q5M7U6

PTM databases

iPTMnetiQ5M7U6
PhosphoSitePlusiQ5M7U6

Expressioni

Gene expression databases

BgeeiENSRNOG00000004959
GenevisibleiQ5M7U6 RN

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.By similarity

GO - Molecular functioni

  • actin filament binding Source: Ensembl
  • cytoskeletal protein binding Source: RGD

Protein-protein interaction databases

BioGridi253032, 3 interactors
IntActiQ5M7U6, 2 interactors
MINTiQ5M7U6
STRINGi10116.ENSRNOP00000006607

Structurei

3D structure databases

ProteinModelPortaliQ5M7U6
SMRiQ5M7U6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP2 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0677 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00910000144135
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiQ5M7U6
KOiK17260
OMAiHLVDVEQ
OrthoDBiEOG091G08WH
PhylomeDBiQ5M7U6
TreeFamiTF300467

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR027306 Arp2
PANTHERiPTHR11937 PTHR11937, 1 hit
PTHR11937:SF149 PTHR11937:SF149, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q5M7U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSQGRKVVV CDNGTGFVKC GYAGSNFPEH IFPALVGRPI IRSTTKVGNI
60 70 80 90 100
EIKDLMVGDE ASELRSMLEV NYPMENGIVR NWDDMKHLWD YTFGPEKLNI
110 120 130 140 150
DTRSCKILLT EPPMNPTKNR EKIVEVMFET YQFSGVYVAI QAVLTLYAQG
160 170 180 190 200
LLTGVVVDSG DGVTHICPVY EGFSLPHLTR RLDIAGRDIT RYLIKLLLLR
210 220 230 240 250
GYAFNHSADF ETVRMIKEKL CYVGYNIEQE QKLALETTVL VESYTLPDGR
260 270 280 290 300
IIKVGGERFE APEALFQPHL INVEGVGVAE LLFNTIQAAD IDTRSEFYKH
310 320 330 340 350
IVLSGGSTMY PGLPSRLERE LKQLYLERVL KGDVEKLSKF KIRIEDPPRR
360 370 380 390
KHMVFLGGAV LADIMKDKDN FWMTRQEYQE KGVRVLEKLG VTVR
Length:394
Mass (Da):44,734
Last modified:February 1, 2005 - v1
Checksum:i283A5F2CFB589CF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088442 mRNA Translation: AAH88442.1
RefSeqiNP_001009268.1, NM_001009268.1
UniGeneiRn.102249
Rn.163721

Genome annotation databases

EnsembliENSRNOT00000006607; ENSRNOP00000006607; ENSRNOG00000004959
GeneIDi289820
KEGGirno:289820
UCSCiRGD:1310826 rat

Similar proteinsi

Entry informationi

Entry nameiARP2_RAT
AccessioniPrimary (citable) accession number: Q5M7U6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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