Q5M7U5 (RAB19_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-19

Gene names

Name:

Rab19

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: InterPro small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 217	217	Ras-related protein Rab-19		PRO_0000244614
Regions
	Nucleotide binding	24 – 31	8	GTP By similarity
	Nucleotide binding	72 – 76	5	GTP By similarity
	Nucleotide binding	130 – 133	4	GTP By similarity
	Motif	46 – 54	9	Effector region By similarity
Amino acid modifications
	Modified residue	217	1	Cysteine methyl ester By similarity
	Lipidation	215	1	S-geranylgeranyl cysteine By similarity
	Lipidation	217	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5M7U5 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: F02E8B85ED390B61	FASTA	217	24,446
	10 20 30 40 50 60 MQFSSAARTV DENVDYLFKV ILIGDSNVGK TCVVQHFKSG VYSESQQNTI GVDFTVRSLE 70 80 90 100 110 120 IDGKKVKMQV WDTAGQERFR TITQSYYRSA HAAIIAYDLT RRSTFESVPH WIHEIEKYGA 130 140 150 160 170 180 ANLVIMLIGN KSDLWEKRHV LFEDACTLAE KYGLLAVLET SAKESRNIDE VFVLMAKELI 190 200 210 ARNSLHLYGE SAQQGLPQDS SPVLVAHVPS ERTHCTC

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC088443 mRNA. Translation: AAH88443.1.
IPI	IPI00200723.
RefSeq	NP_001019497.1. NM_001024326.1.
UniGene	Rn.53184.
3D structure databases
ProteinModelPortal	Q5M7U5.
ModBase	Search...
Proteomic databases
PaxDb	Q5M7U5.
PRIDE	Q5M7U5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000012280; ENSRNOP00000012280; ENSRNOG00000009030.
GeneID	500088.
KEGG	rno:500088.
UCSC	RGD:1565263. rat.
Organism-specific databases
CTD	401409.
RGD	1565263. Rab19.
Phylogenomic databases
eggNOG	COG1100.
GeneTree	ENSGT00700000104044.
HOGENOM	HOG000233968.
HOVERGEN	HBG009351.
InParanoid	Q5M7U5.
OMA	RNSLHLY.
OrthoDB	EOG4WQ13N.
Gene expression databases
Genevestigator	Q5M7U5.
GermOnline	ENSRNOG00000009030. Rattus norvegicus.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	705052.

Entry information

Entry name

RAB19_RAT

Accession

Primary (citable) accession number: Q5M7U5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	February 1, 2005
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program