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Q5M7U5

- RAB19_RAT

UniProt

Q5M7U5 - RAB19_RAT

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Protein

Ras-related protein Rab-19

Gene

Rab19

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318GTPBy similarity
Nucleotide bindingi72 – 765GTPBy similarity
Nucleotide bindingi130 – 1334GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein transport Source: InterPro
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-19
Gene namesi
Name:Rab19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi1565263. Rab19.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Ras-related protein Rab-19PRO_0000244614Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi215 – 2151S-geranylgeranyl cysteineBy similarity
Modified residuei217 – 2171Cysteine methyl esterBy similarity
Lipidationi217 – 2171S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ5M7U5.
PRIDEiQ5M7U5.

Expressioni

Gene expression databases

GenevestigatoriQ5M7U5.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012280.

Structurei

3D structure databases

ProteinModelPortaliQ5M7U5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 549Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ5M7U5.
KOiK17047.
OMAiNKCDLWE.
OrthoDBiEOG7NGQCK.
PhylomeDBiQ5M7U5.
TreeFamiTF300097.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M7U5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQFSSAARTV DENVDYLFKV ILIGDSNVGK TCVVQHFKSG VYSESQQNTI
60 70 80 90 100
GVDFTVRSLE IDGKKVKMQV WDTAGQERFR TITQSYYRSA HAAIIAYDLT
110 120 130 140 150
RRSTFESVPH WIHEIEKYGA ANLVIMLIGN KSDLWEKRHV LFEDACTLAE
160 170 180 190 200
KYGLLAVLET SAKESRNIDE VFVLMAKELI ARNSLHLYGE SAQQGLPQDS
210
SPVLVAHVPS ERTHCTC
Length:217
Mass (Da):24,446
Last modified:February 1, 2005 - v1
Checksum:iF02E8B85ED390B61
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC088443 mRNA. Translation: AAH88443.1.
RefSeqiNP_001019497.1. NM_001024326.1.
UniGeneiRn.53184.

Genome annotation databases

EnsembliENSRNOT00000012280; ENSRNOP00000012280; ENSRNOG00000009030.
GeneIDi500088.
KEGGirno:500088.
UCSCiRGD:1565263. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC088443 mRNA. Translation: AAH88443.1 .
RefSeqi NP_001019497.1. NM_001024326.1.
UniGenei Rn.53184.

3D structure databases

ProteinModelPortali Q5M7U5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000012280.

Proteomic databases

PaxDbi Q5M7U5.
PRIDEi Q5M7U5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000012280 ; ENSRNOP00000012280 ; ENSRNOG00000009030 .
GeneIDi 500088.
KEGGi rno:500088.
UCSCi RGD:1565263. rat.

Organism-specific databases

CTDi 401409.
RGDi 1565263. Rab19.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000118841.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi Q5M7U5.
KOi K17047.
OMAi NKCDLWE.
OrthoDBi EOG7NGQCK.
PhylomeDBi Q5M7U5.
TreeFami TF300097.

Miscellaneous databases

NextBioi 705052.
PROi Q5M7U5.

Gene expression databases

Genevestigatori Q5M7U5.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiRAB19_RAT
AccessioniPrimary (citable) accession number: Q5M7U5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: February 1, 2005
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3