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Q5M7U5

- RAB19_RAT

UniProt

Q5M7U5 - RAB19_RAT

Protein

Ras-related protein Rab-19

Gene

Rab19

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi24 – 318GTPBy similarity
    Nucleotide bindingi72 – 765GTPBy similarity
    Nucleotide bindingi130 – 1334GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein transport Source: InterPro
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-19
    Gene namesi
    Name:Rab19
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi1565263. Rab19.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 217217Ras-related protein Rab-19PRO_0000244614Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi215 – 2151S-geranylgeranyl cysteineBy similarity
    Modified residuei217 – 2171Cysteine methyl esterBy similarity
    Lipidationi217 – 2171S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiQ5M7U5.
    PRIDEiQ5M7U5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5M7U5.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000012280.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5M7U5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi46 – 549Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00710000106357.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiQ5M7U5.
    KOiK17047.
    OMAiNKCDLWE.
    OrthoDBiEOG7NGQCK.
    PhylomeDBiQ5M7U5.
    TreeFamiTF300097.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5M7U5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQFSSAARTV DENVDYLFKV ILIGDSNVGK TCVVQHFKSG VYSESQQNTI    50
    GVDFTVRSLE IDGKKVKMQV WDTAGQERFR TITQSYYRSA HAAIIAYDLT 100
    RRSTFESVPH WIHEIEKYGA ANLVIMLIGN KSDLWEKRHV LFEDACTLAE 150
    KYGLLAVLET SAKESRNIDE VFVLMAKELI ARNSLHLYGE SAQQGLPQDS 200
    SPVLVAHVPS ERTHCTC 217
    Length:217
    Mass (Da):24,446
    Last modified:February 1, 2005 - v1
    Checksum:iF02E8B85ED390B61
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC088443 mRNA. Translation: AAH88443.1.
    RefSeqiNP_001019497.1. NM_001024326.1.
    UniGeneiRn.53184.

    Genome annotation databases

    EnsembliENSRNOT00000012280; ENSRNOP00000012280; ENSRNOG00000009030.
    GeneIDi500088.
    KEGGirno:500088.
    UCSCiRGD:1565263. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC088443 mRNA. Translation: AAH88443.1 .
    RefSeqi NP_001019497.1. NM_001024326.1.
    UniGenei Rn.53184.

    3D structure databases

    ProteinModelPortali Q5M7U5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000012280.

    Proteomic databases

    PaxDbi Q5M7U5.
    PRIDEi Q5M7U5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000012280 ; ENSRNOP00000012280 ; ENSRNOG00000009030 .
    GeneIDi 500088.
    KEGGi rno:500088.
    UCSCi RGD:1565263. rat.

    Organism-specific databases

    CTDi 401409.
    RGDi 1565263. Rab19.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00710000106357.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi Q5M7U5.
    KOi K17047.
    OMAi NKCDLWE.
    OrthoDBi EOG7NGQCK.
    PhylomeDBi Q5M7U5.
    TreeFami TF300097.

    Miscellaneous databases

    NextBioi 705052.
    PROi Q5M7U5.

    Gene expression databases

    Genevestigatori Q5M7U5.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiRAB19_RAT
    AccessioniPrimary (citable) accession number: Q5M7U5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3