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Q5M7U5 (RAB19_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-19
Gene names
Name:Rab19
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   LigandGTP-binding
Nucleotide-binding
   PTMLipoprotein
Methylation
Prenylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein transport

Inferred from electronic annotation. Source: InterPro

small GTPase mediated signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 217217Ras-related protein Rab-19
PRO_0000244614

Regions

Nucleotide binding24 – 318GTP By similarity
Nucleotide binding72 – 765GTP By similarity
Nucleotide binding130 – 1334GTP By similarity
Motif46 – 549Effector region By similarity

Amino acid modifications

Modified residue2171Cysteine methyl ester By similarity
Lipidation2151S-geranylgeranyl cysteine By similarity
Lipidation2171S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5M7U5 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: F02E8B85ED390B61

FASTA21724,446
        10         20         30         40         50         60 
MQFSSAARTV DENVDYLFKV ILIGDSNVGK TCVVQHFKSG VYSESQQNTI GVDFTVRSLE 

        70         80         90        100        110        120 
IDGKKVKMQV WDTAGQERFR TITQSYYRSA HAAIIAYDLT RRSTFESVPH WIHEIEKYGA 

       130        140        150        160        170        180 
ANLVIMLIGN KSDLWEKRHV LFEDACTLAE KYGLLAVLET SAKESRNIDE VFVLMAKELI 

       190        200        210 
ARNSLHLYGE SAQQGLPQDS SPVLVAHVPS ERTHCTC 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC088443 mRNA. Translation: AAH88443.1.
RefSeqNP_001019497.1. NM_001024326.1.
UniGeneRn.53184.

3D structure databases

ProteinModelPortalQ5M7U5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000012280.

Proteomic databases

PaxDbQ5M7U5.
PRIDEQ5M7U5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000012280; ENSRNOP00000012280; ENSRNOG00000009030.
GeneID500088.
KEGGrno:500088.
UCSCRGD:1565263. rat.

Organism-specific databases

CTD401409.
RGD1565263. Rab19.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00710000106357.
HOGENOMHOG000233968.
HOVERGENHBG009351.
InParanoidQ5M7U5.
KOK17047.
OMANKCDLWE.
OrthoDBEOG7NGQCK.
PhylomeDBQ5M7U5.
TreeFamTF300097.

Gene expression databases

GenevestigatorQ5M7U5.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio705052.
PROQ5M7U5.

Entry information

Entry nameRAB19_RAT
AccessionPrimary (citable) accession number: Q5M7U5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: February 1, 2005
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families