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Protein

Ras-related protein Rab-19

Gene

Rab19

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318GTPBy similarity
Nucleotide bindingi72 – 765GTPBy similarity
Nucleotide bindingi130 – 1334GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: GO_Central
  2. GTPase activity Source: GO_Central
  3. GTP binding Source: GO_Central

GO - Biological processi

  1. GTP catabolic process Source: GO_Central
  2. intracellular protein transport Source: GO_Central
  3. Rab protein signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-19
Gene namesi
Name:Rab19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi1565263. Rab19.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. endosome Source: GO_Central
  2. extracellular vesicular exosome Source: Ensembl
  3. Golgi apparatus Source: GO_Central
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Ras-related protein Rab-19PRO_0000244614Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi215 – 2151S-geranylgeranyl cysteineBy similarity
Modified residuei217 – 2171Cysteine methyl esterBy similarity
Lipidationi217 – 2171S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ5M7U5.
PRIDEiQ5M7U5.

Expressioni

Gene expression databases

GenevestigatoriQ5M7U5.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012280.

Structurei

3D structure databases

ProteinModelPortaliQ5M7U5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 549Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ5M7U5.
KOiK17047.
OMAiNKCDLWE.
OrthoDBiEOG7NGQCK.
PhylomeDBiQ5M7U5.
TreeFamiTF300097.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M7U5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFSSAARTV DENVDYLFKV ILIGDSNVGK TCVVQHFKSG VYSESQQNTI
60 70 80 90 100
GVDFTVRSLE IDGKKVKMQV WDTAGQERFR TITQSYYRSA HAAIIAYDLT
110 120 130 140 150
RRSTFESVPH WIHEIEKYGA ANLVIMLIGN KSDLWEKRHV LFEDACTLAE
160 170 180 190 200
KYGLLAVLET SAKESRNIDE VFVLMAKELI ARNSLHLYGE SAQQGLPQDS
210
SPVLVAHVPS ERTHCTC
Length:217
Mass (Da):24,446
Last modified:February 1, 2005 - v1
Checksum:iF02E8B85ED390B61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088443 mRNA. Translation: AAH88443.1.
RefSeqiNP_001019497.1. NM_001024326.1.
XP_008761042.1. XM_008762820.1.
UniGeneiRn.53184.

Genome annotation databases

EnsembliENSRNOT00000012280; ENSRNOP00000012280; ENSRNOG00000009030.
GeneIDi500088.
KEGGirno:500088.
UCSCiRGD:1565263. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088443 mRNA. Translation: AAH88443.1.
RefSeqiNP_001019497.1. NM_001024326.1.
XP_008761042.1. XM_008762820.1.
UniGeneiRn.53184.

3D structure databases

ProteinModelPortaliQ5M7U5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012280.

Proteomic databases

PaxDbiQ5M7U5.
PRIDEiQ5M7U5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012280; ENSRNOP00000012280; ENSRNOG00000009030.
GeneIDi500088.
KEGGirno:500088.
UCSCiRGD:1565263. rat.

Organism-specific databases

CTDi401409.
RGDi1565263. Rab19.

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ5M7U5.
KOiK17047.
OMAiNKCDLWE.
OrthoDBiEOG7NGQCK.
PhylomeDBiQ5M7U5.
TreeFamiTF300097.

Miscellaneous databases

NextBioi705052.
PROiQ5M7U5.

Gene expression databases

GenevestigatoriQ5M7U5.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiRAB19_RAT
AccessioniPrimary (citable) accession number: Q5M7U5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: February 1, 2005
Last modified: February 4, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.