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Protein

V-type proton ATPase subunit

Gene

Atp6v0d1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transportUniRule annotation, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-1222556. ROS, RNS production in phagocytes.
R-RNO-77387. Insulin receptor recycling.
R-RNO-917977. Transferrin endocytosis and recycling.
R-RNO-983712. Ion channel transport.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunitUniRule annotation
Gene namesi
Name:Atp6v0d1Imported
ORF Names:rCG_51062Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1306159. Atp6v0d1.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • axon terminus Source: RGD
  • centrosome Source: Ensembl
  • early endosome Source: GO_Central
  • extracellular exosome Source: Ensembl
  • lysosomal membrane Source: GO_Central
  • neuron projection Source: RGD
  • protein complex Source: RGD
  • proton-transporting V-type ATPase, V0 domain Source: InterPro
  • synaptic vesicle Source: RGD
  • vacuolar proton-transporting V-type ATPase complex Source: GO_Central

Expressioni

Gene expression databases

BgeeiENSRNOG00000017235.
ExpressionAtlasiQ5M7T6. baseline and differential.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.UniRule annotation

GO - Molecular functioni

  • protein complex binding Source: RGD

Protein-protein interaction databases

IntActiQ5M7T6. 1 interactor.
STRINGi10116.ENSRNOP00000023606.

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase V0D/AC39 subunit family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2957. Eukaryota.
COG1527. LUCA.
GeneTreeiENSGT00390000002200.
HOGENOMiHOG000199065.
HOVERGENiHBG018065.
KOiK02146.
OMAiFMDFITY.
OrthoDBiEOG091G09L5.
TreeFamiTF300857.

Family and domain databases

Gene3Di1.20.1690.10. 2 hits.
InterProiView protein in InterPro
IPR002843. ATPase_V0-cplx_csu/dsu.
IPR016727. ATPase_V0-cplx_dsu.
IPR035067. V-type_ATPase_suC.
PANTHERiPTHR11028. PTHR11028. 1 hit.
PfamiView protein in Pfam
PF01992. vATP-synt_AC39. 1 hit.
PIRSFiPIRSF018497. V-ATP_synth_D. 1 hit.
SUPFAMiSSF103486. SSF103486. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5M7T6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFFPELYFN VDNGYLEGLV RGLKAGVLSQ ADYLNLVQCE TLEDLKLHLQ
60 70 80 90 100
STDYGNFLAN EASPLTVSVI DDKLKEKMVV EFRHMRNHAY EPLASFLDFI
110 120 130 140 150
TYSYMIDNVI LLITGTLHQR SIAELVPKCH PLGSFEQMEA VNIAQTPAEL
160 170 180 190 200
YNAILVDTPL AAFFQDCISE QDLDEMNIEI IRNTLYKAYL ESFYKFCTLL
210 220 230 240 250
GGTTADAMCP ILEFEADRRA FIITINSFGT ELSKEDRAKL FPHCGRLYPE
260 270 280 290 300
GLAQLARADD YEQVKNVADY YPEYKLLFEG AGSNPGDKTL EDRFFEHEVK
310 320 330 340 350
LNKLAFLNQF HFGVFYAFVK LKEQECRNIV WIAECIAQRH RAKIDNYIPI

F
Length:351
Mass (Da):40,301
Last modified:February 1, 2005 - v1
Checksum:i62CDF67B982124C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116220 Genomic DNA. No translation available.
BC088462 mRNA. Translation: AAH88462.1.
CH473972 Genomic DNA. Translation: EDL92381.1.
RefSeqiNP_001011927.1. NM_001011927.1.
UniGeneiRn.94752.

Genome annotation databases

EnsembliENSRNOT00000023606; ENSRNOP00000023606; ENSRNOG00000017235.
GeneIDi291969.
KEGGirno:291969.
UCSCiRGD:1306159. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ5M7T6_RAT
AccessioniPrimary (citable) accession number: Q5M7T6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 2005
Last sequence update: February 1, 2005
Last modified: July 5, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported