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Protein

Breast cancer metastasis-suppressor 1 homolog

Gene

Brms1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Breast cancer metastasis-suppressor 1 homolog
Gene namesi
Name:Brms1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1311057. Brms1.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Predominantly nuclear.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Breast cancer metastasis-suppressor 1 homologPRO_0000305307Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki242 – 242Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ5M7T3.

Expressioni

Gene expression databases

GenevisibleiQ5M7T3. RN.

Interactioni

Subunit structurei

Homohexamer (Potential). Interacts with SNX6, HDAC1 and RELA. Interacts with ARID4A. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, SUDS3, ARID4A, HDAC1 and HDAC2. Interacts with SPOP; this recruits the protein to a ubiquitin ligase complex containing SPOP and CUL3 (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067358.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili51 – 9848By similarityAdd
BLAST

Domaini

Contains an N-terminal anti-parallel coiled coil formed by two BRMS1 chains; this region can form homohexamers.By similarity

Sequence similaritiesi

Belongs to the BRMS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4466. Eukaryota.
ENOG410Y9N9. LUCA.
GeneTreeiENSGT00530000063177.
HOGENOMiHOG000007483.
HOVERGENiHBG050734.
InParanoidiQ5M7T3.
KOiK19196.
OMAiEEANECD.
OrthoDBiEOG783MZ0.
PhylomeDBiQ5M7T3.
TreeFamiTF323740.

Family and domain databases

InterProiIPR013907. Sds3.
[Graphical view]
PfamiPF08598. Sds3. 1 hit.
[Graphical view]
SMARTiSM01401. Sds3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M7T3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIQPSGKET EEMEAEGDSA AEMNGEADES EEERSGSQTE SEEESSEMDD
60 70 80 90 100
EDYERRRSEC VSEMLDLEKQ FSELKEKLFR ERLSQLRLRL EEVGAERAPE
110 120 130 140 150
YTEPLGGLQQ SLKIRIQVAG IYKGFCLDVI RNKYECELQG AKQHLESEKL
160 170 180 190 200
LLYDTLLGEL QERIQRLEED RQSLDISSEW WDDKLHSRGS SKTWDSVPPS
210 220 230 240
KRKKAPLVSG PYIVYMLQEI DILEDWTAIK KARAAVSPQK RKADGP
Length:246
Mass (Da):28,306
Last modified:February 1, 2005 - v1
Checksum:i2C9E5AFEC959A902
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088469 mRNA. Translation: AAH88469.1.
RefSeqiNP_001009605.1. NM_001009605.1.
XP_003749086.1. XM_003749038.3.
UniGeneiRn.2839.

Genome annotation databases

EnsembliENSRNOT00000027258; ENSRNOP00000027258; ENSRNOG00000020117.
GeneIDi100911841.
293668.
KEGGirno:100911841.
rno:293668.
UCSCiRGD:1311057. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088469 mRNA. Translation: AAH88469.1.
RefSeqiNP_001009605.1. NM_001009605.1.
XP_003749086.1. XM_003749038.3.
UniGeneiRn.2839.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067358.

Proteomic databases

PaxDbiQ5M7T3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027258; ENSRNOP00000027258; ENSRNOG00000020117.
GeneIDi100911841.
293668.
KEGGirno:100911841.
rno:293668.
UCSCiRGD:1311057. rat.

Organism-specific databases

CTDi25855.
RGDi1311057. Brms1.

Phylogenomic databases

eggNOGiKOG4466. Eukaryota.
ENOG410Y9N9. LUCA.
GeneTreeiENSGT00530000063177.
HOGENOMiHOG000007483.
HOVERGENiHBG050734.
InParanoidiQ5M7T3.
KOiK19196.
OMAiEEANECD.
OrthoDBiEOG783MZ0.
PhylomeDBiQ5M7T3.
TreeFamiTF323740.

Miscellaneous databases

PROiQ5M7T3.

Gene expression databases

GenevisibleiQ5M7T3. RN.

Family and domain databases

InterProiIPR013907. Sds3.
[Graphical view]
PfamiPF08598. Sds3. 1 hit.
[Graphical view]
SMARTiSM01401. Sds3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiBRMS1_RAT
AccessioniPrimary (citable) accession number: Q5M7T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: February 1, 2005
Last modified: July 6, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.