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Protein

Probable cytosolic iron-sulfur protein assembly protein CIAO1

Gene

Ciao1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Chromosome partition

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosolic iron-sulfur protein assembly protein CIAO1UniRule annotation
Alternative name(s):
WD repeat-containing protein 39UniRule annotation
Gene namesi
Name:Ciao1UniRule annotation
Synonyms:Wdr39
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1307285. Ciao1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Probable cytosolic iron-sulfur protein assembly protein CIAO1PRO_0000281107Add
BLAST

Proteomic databases

PaxDbiQ5M7T1.
PRIDEiQ5M7T1.

Expressioni

Gene expression databases

ExpressionAtlasiQ5M7T1. baseline and differential.
GenevisibleiQ5M7T1. RN.

Interactioni

Subunit structurei

Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017603.

Structurei

3D structure databases

ProteinModelPortaliQ5M7T1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati14 – 5340WD 1Add
BLAST
Repeati59 – 9840WD 2Add
BLAST
Repeati103 – 14240WD 3Add
BLAST
Repeati148 – 18740WD 4Add
BLAST
Repeati192 – 23140WD 5Add
BLAST
Repeati250 – 28940WD 6Add
BLAST
Repeati301 – 33939WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat CIA1 family.UniRule annotation
Contains 7 WD repeats.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0645. Eukaryota.
ENOG410XRMA. LUCA.
GeneTreeiENSGT00820000127115.
HOGENOMiHOG000208901.
HOVERGENiHBG056532.
InParanoidiQ5M7T1.
OMAiWEVAGDD.
OrthoDBiEOG7XH6Q1.
PhylomeDBiQ5M7T1.
TreeFamiTF318181.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03037. ciao1.
InterProiIPR028608. CIAO1/Cia1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 6 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M7T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDALVLQSR VPAHPDSRCW FLAWNPTGTL LASCGGDRKI RIWGTEGDSW
60 70 80 90 100
ICKSVLSEGH QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT
110 120 130 140 150
LEGHENEVKS VAWAPSGNLL ATCSRDKSVW VWEVDEEDEY ECVSVLNSHT
160 170 180 190 200
QDVKHVVWHP SQELLASASY DDTVKLYQEE GDDWVCCATL EGHESTVWSI
210 220 230 240 250
AFDPSGQRLA SCSDDRTVRI WRQYLPGNEQ GVACSGSDPS WKCVCTLSGF
260 270 280 290 300
HTRTIYDVAW CQLTGALATA CGDDAIRVFE EDPGSDPQQP TFSLTAHLRQ
310 320 330
AHSQDVNCVA WNPKEAGLLA SCSDDGEVAF WEYHQPAGL
Length:339
Mass (Da):37,618
Last modified:February 1, 2005 - v1
Checksum:i6B257EB84356C0F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088474 mRNA. Translation: AAH88474.1.
RefSeqiNP_001008766.1. NM_001008766.1.
UniGeneiRn.108832.

Genome annotation databases

EnsembliENSRNOT00000017603; ENSRNOP00000017603; ENSRNOG00000012638.
GeneIDi29231.
KEGGirno:29231.
UCSCiRGD:1307285. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088474 mRNA. Translation: AAH88474.1.
RefSeqiNP_001008766.1. NM_001008766.1.
UniGeneiRn.108832.

3D structure databases

ProteinModelPortaliQ5M7T1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017603.

Proteomic databases

PaxDbiQ5M7T1.
PRIDEiQ5M7T1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017603; ENSRNOP00000017603; ENSRNOG00000012638.
GeneIDi29231.
KEGGirno:29231.
UCSCiRGD:1307285. rat.

Organism-specific databases

CTDi9391.
RGDi1307285. Ciao1.

Phylogenomic databases

eggNOGiKOG0645. Eukaryota.
ENOG410XRMA. LUCA.
GeneTreeiENSGT00820000127115.
HOGENOMiHOG000208901.
HOVERGENiHBG056532.
InParanoidiQ5M7T1.
OMAiWEVAGDD.
OrthoDBiEOG7XH6Q1.
PhylomeDBiQ5M7T1.
TreeFamiTF318181.

Miscellaneous databases

NextBioi608478.
PROiQ5M7T1.

Gene expression databases

ExpressionAtlasiQ5M7T1. baseline and differential.
GenevisibleiQ5M7T1. RN.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03037. ciao1.
InterProiIPR028608. CIAO1/Cia1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 6 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiCIAO1_RAT
AccessioniPrimary (citable) accession number: Q5M7T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: February 1, 2005
Last modified: February 17, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.