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Protein

Probable cytosolic iron-sulfur protein assembly protein CIAO1

Gene

Ciao1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.UniRule annotation

GO - Biological processi

Keywordsi

Biological processChromosome partition

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosolic iron-sulfur protein assembly protein CIAO1UniRule annotation
Alternative name(s):
WD repeat-containing protein 39UniRule annotation
Gene namesi
Name:Ciao1UniRule annotation
Synonyms:Wdr39
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1307285 Ciao1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002811071 – 339Probable cytosolic iron-sulfur protein assembly protein CIAO1Add BLAST339

Proteomic databases

PaxDbiQ5M7T1
PRIDEiQ5M7T1

PTM databases

PhosphoSitePlusiQ5M7T1

Expressioni

Gene expression databases

BgeeiENSRNOG00000012638
ExpressionAtlasiQ5M7T1 baseline and differential
GenevisibleiQ5M7T1 RN

Interactioni

Subunit structurei

Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017603

Structurei

3D structure databases

ProteinModelPortaliQ5M7T1
SMRiQ5M7T1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati14 – 53WD 1Add BLAST40
Repeati59 – 98WD 2Add BLAST40
Repeati103 – 142WD 3Add BLAST40
Repeati148 – 187WD 4Add BLAST40
Repeati192 – 231WD 5Add BLAST40
Repeati250 – 289WD 6Add BLAST40
Repeati301 – 339WD 7Add BLAST39

Sequence similaritiesi

Belongs to the WD repeat CIA1 family.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0645 Eukaryota
ENOG410XRMA LUCA
GeneTreeiENSGT00890000139406
HOGENOMiHOG000208901
HOVERGENiHBG056532
InParanoidiQ5M7T1
OMAiVWKCVCT
OrthoDBiEOG091G0AAM
PhylomeDBiQ5M7T1
TreeFamiTF318181

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_03037 ciao1, 1 hit
InterProiView protein in InterPro
IPR028608 CIAO1/Cia1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19920 PTHR19920, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 6 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q5M7T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDALVLQSR VPAHPDSRCW FLAWNPTGTL LASCGGDRKI RIWGTEGDSW
60 70 80 90 100
ICKSVLSEGH QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT
110 120 130 140 150
LEGHENEVKS VAWAPSGNLL ATCSRDKSVW VWEVDEEDEY ECVSVLNSHT
160 170 180 190 200
QDVKHVVWHP SQELLASASY DDTVKLYQEE GDDWVCCATL EGHESTVWSI
210 220 230 240 250
AFDPSGQRLA SCSDDRTVRI WRQYLPGNEQ GVACSGSDPS WKCVCTLSGF
260 270 280 290 300
HTRTIYDVAW CQLTGALATA CGDDAIRVFE EDPGSDPQQP TFSLTAHLRQ
310 320 330
AHSQDVNCVA WNPKEAGLLA SCSDDGEVAF WEYHQPAGL
Length:339
Mass (Da):37,618
Last modified:February 1, 2005 - v1
Checksum:i6B257EB84356C0F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088474 mRNA Translation: AAH88474.1
RefSeqiNP_001008766.1, NM_001008766.1
UniGeneiRn.108832

Genome annotation databases

EnsembliENSRNOT00000017603; ENSRNOP00000017603; ENSRNOG00000012638
GeneIDi29231
KEGGirno:29231
UCSCiRGD:1307285 rat

Similar proteinsi

Entry informationi

Entry nameiCIAO1_RAT
AccessioniPrimary (citable) accession number: Q5M7T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: February 1, 2005
Last modified: April 25, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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