Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Folliculin

Gene

flcn

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Folliculin
Gene namesi
Name:flcn
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-1003590 flcn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002239431 – 579FolliculinAdd BLAST579

Proteomic databases

PaxDbiQ5M7Q1

Expressioni

Gene expression databases

BgeeiENSXETG00000005745

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000012652

Structurei

3D structure databases

SMRiQ5M7Q1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 242uDENN FLCN/SMCR8-typePROSITE-ProRule annotationAdd BLAST157
Domaini337 – 491cDENN FLCN/SMCR8-typePROSITE-ProRule annotationAdd BLAST155
Domaini493 – 558dDENN FLCN/SMCR8-typePROSITE-ProRule annotationAdd BLAST66

Sequence similaritiesi

Belongs to the folliculin family.Curated

Phylogenomic databases

eggNOGiKOG3715 Eukaryota
ENOG410XQ9Y LUCA
GeneTreeiENSGT00390000009864
HOGENOMiHOG000052507
HOVERGENiHBG081531
InParanoidiQ5M7Q1
KOiK09594
OMAiRCVACTS
OrthoDBiEOG091G0C9Z
TreeFamiTF315084

Family and domain databases

InterProiView protein in InterPro
IPR037521 FLCN/SMCR8_DENN
IPR021713 Folliculin
IPR032035 Folliculin_C
IPR037520 Folliculin_N
PANTHERiPTHR31441 PTHR31441, 1 hit
PfamiView protein in Pfam
PF11704 Folliculin, 1 hit
PF16692 Folliculin_C, 1 hit
PROSITEiView protein in PROSITE
PS51834 DENN_FLCN_SMCR8, 1 hit

Sequencei

Sequence statusi: Complete.

Q5M7Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAIVALCHF CELHGPRTLF CTEALHSPHP QGASCGDSIG QGEQAEDEEM
60 70 80 90 100
GIQMSSRIRC HSPAEGASAD SNSPRPKKSD MCEGCRSLAA GHPGYISHDK
110 120 130 140 150
ETSIKYVSHQ HPNHPQLFSI VRQACVRSLS CEVCPGREGP IFFGDEQHGF
160 170 180 190 200
VFSHTFFIKD SLARGFQRWY SIIVIMMDRI YLINSWPFLL AKIRGVIDEL
210 220 230 240 250
QGKALKVFEA EQFGCPQRPL RINTAFTPFL HQRNGNAARS LTSLTSDDNL
260 270 280 290 300
WACLHTSFAW LLKACGCRLT EKLLEGAPTE DTLVQMEKQA DLEEECAARE
310 320 330 340 350
VADGEEGRPR LQPELMEGRE LSKCPTESSV LSDCSWNMVQ RRMGVFRSLR
360 370 380 390 400
HMRQVLGASA FRMLAWHVLM GNQVIWKGQD QELIQSAFDV LQAMLPVGCV
410 420 430 440 450
RVIPYSEKYE DAYRCNFLGL SPQAEIPLHV QSSEFSVMVD VRHANRSNLY
460 470 480 490 500
PALFVDDEPL SKYEFVVASG SPVTIDKVGL TILNKIEAAL SNENLSMDVV
510 520 530 540 550
DQCLICLKEE WMNKVKVLFK FTKVDSRPKE DTQKLLGILG ASEEDNIKLL
560 570
KFWMTGLSKT YKSHLMSSVR SPTASECRN
Length:579
Mass (Da):65,018
Last modified:February 1, 2005 - v1
Checksum:iBA2B446785A030C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088516 mRNA Translation: AAH88516.1
RefSeqiNP_001011353.1, NM_001011353.1
UniGeneiStr.22035

Genome annotation databases

EnsembliENSXETT00000012652; ENSXETP00000012652; ENSXETG00000005745
GeneIDi496819
KEGGixtr:496819

Similar proteinsi

Entry informationi

Entry nameiFLCN_XENTR
AccessioniPrimary (citable) accession number: Q5M7Q1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health