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Protein

Folliculin

Gene

flcn

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Folliculin
Gene namesi
Name:flcn
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-1003590. flcn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 579579FolliculinPRO_0000223943Add
BLAST

Proteomic databases

PaxDbiQ5M7Q1.

Expressioni

Gene expression databases

BgeeiQ5M7Q1.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000012652.

Family & Domainsi

Sequence similaritiesi

Belongs to the folliculin family.Curated

Phylogenomic databases

eggNOGiKOG3715. Eukaryota.
ENOG410XQ9Y. LUCA.
GeneTreeiENSGT00390000009864.
HOGENOMiHOG000052507.
HOVERGENiHBG081531.
InParanoidiQ5M7Q1.
KOiK09594.
OMAiGNTREQW.
OrthoDBiEOG7PS1FX.
TreeFamiTF315084.

Family and domain databases

InterProiIPR021713. Folliculin.
IPR032035. Folliculin_C.
[Graphical view]
PANTHERiPTHR31441. PTHR31441. 1 hit.
PfamiPF16692. Folliculin_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M7Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAIVALCHF CELHGPRTLF CTEALHSPHP QGASCGDSIG QGEQAEDEEM
60 70 80 90 100
GIQMSSRIRC HSPAEGASAD SNSPRPKKSD MCEGCRSLAA GHPGYISHDK
110 120 130 140 150
ETSIKYVSHQ HPNHPQLFSI VRQACVRSLS CEVCPGREGP IFFGDEQHGF
160 170 180 190 200
VFSHTFFIKD SLARGFQRWY SIIVIMMDRI YLINSWPFLL AKIRGVIDEL
210 220 230 240 250
QGKALKVFEA EQFGCPQRPL RINTAFTPFL HQRNGNAARS LTSLTSDDNL
260 270 280 290 300
WACLHTSFAW LLKACGCRLT EKLLEGAPTE DTLVQMEKQA DLEEECAARE
310 320 330 340 350
VADGEEGRPR LQPELMEGRE LSKCPTESSV LSDCSWNMVQ RRMGVFRSLR
360 370 380 390 400
HMRQVLGASA FRMLAWHVLM GNQVIWKGQD QELIQSAFDV LQAMLPVGCV
410 420 430 440 450
RVIPYSEKYE DAYRCNFLGL SPQAEIPLHV QSSEFSVMVD VRHANRSNLY
460 470 480 490 500
PALFVDDEPL SKYEFVVASG SPVTIDKVGL TILNKIEAAL SNENLSMDVV
510 520 530 540 550
DQCLICLKEE WMNKVKVLFK FTKVDSRPKE DTQKLLGILG ASEEDNIKLL
560 570
KFWMTGLSKT YKSHLMSSVR SPTASECRN
Length:579
Mass (Da):65,018
Last modified:February 1, 2005 - v1
Checksum:iBA2B446785A030C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088516 mRNA. Translation: AAH88516.1.
RefSeqiNP_001011353.1. NM_001011353.1.
UniGeneiStr.22035.

Genome annotation databases

EnsembliENSXETT00000012652; ENSXETP00000012652; ENSXETG00000005745.
GeneIDi496819.
KEGGixtr:496819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088516 mRNA. Translation: AAH88516.1.
RefSeqiNP_001011353.1. NM_001011353.1.
UniGeneiStr.22035.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000012652.

Proteomic databases

PaxDbiQ5M7Q1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000012652; ENSXETP00000012652; ENSXETG00000005745.
GeneIDi496819.
KEGGixtr:496819.

Organism-specific databases

CTDi201163.
XenbaseiXB-GENE-1003590. flcn.

Phylogenomic databases

eggNOGiKOG3715. Eukaryota.
ENOG410XQ9Y. LUCA.
GeneTreeiENSGT00390000009864.
HOGENOMiHOG000052507.
HOVERGENiHBG081531.
InParanoidiQ5M7Q1.
KOiK09594.
OMAiGNTREQW.
OrthoDBiEOG7PS1FX.
TreeFamiTF315084.

Gene expression databases

BgeeiQ5M7Q1.

Family and domain databases

InterProiIPR021713. Folliculin.
IPR032035. Folliculin_C.
[Graphical view]
PANTHERiPTHR31441. PTHR31441. 1 hit.
PfamiPF16692. Folliculin_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiFLCN_XENTR
AccessioniPrimary (citable) accession number: Q5M7Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 1, 2005
Last modified: January 20, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.