Q5M7F4 (MOG2B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-acylglycerol O-acyltransferase 2-B
EC=2.3.1.22

Alternative name(s):
Acyl-CoA:monoacylglycerol acyltransferase 2-B
Short name=MGAT2-B
Monoacylglycerol O-acyltransferase 2-B

Gene names

Name:

mogat2-b

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA By similarity.
Catalytic activity	Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
Pathway	Glycerolipid metabolism; triacylglycerol biosynthesis.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the diacylglycerol acyltransferase family.

Ontologies

Keywords
Biological process	Glycerol metabolism Lipid metabolism Lipid synthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Acyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	glycerol metabolic process Inferred from electronic annotation. Source: UniProtKB-KW lipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2-acylglycerol O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	2-acylglycerol O-acyltransferase 2-B		PRO_0000249065
Regions
	Transmembrane	24 – 44	21	Helical; Potential
	Transmembrane	104 – 124	21	Helical; Potential
Amino acid modifications
	Glycosylation	206	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5M7F4 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: F0DB1334DAA9D837	FASTA	335	37,886
	10 20 30 40 50 60 MWIHFAPLRI PFSRRLQTVA VLQWAVSFLA MAQCCIALYI LLLFSRYWFL ALLYGVWLYL 70 80 90 100 110 120 DWDTPSKGGR RSNWVRSWIV WKYFAEYFPI KLLCTAPLDP KYNYIMGFHP HGVLVVGAFG 130 140 150 160 170 180 NFCTEGTGFS RLFPGLTPHL LMLPAWFRVP FFREYIMSGS LVSSDRSSAH YLLSQKSGGQ 190 200 210 220 230 240 ALVIAVGGPP EALDAKPGEL TLQLLNRTGF IKMALTHGAH LVPVLSFGEN DLYNQVNNPR 250 260 270 280 290 300 GSLLRTTQEK LQKVLGIALP LFHGRGVFQY SWGLLPHRRP IYTVVGSPIP VAKTPCPTQE 310 320 330 QISSLHALYV AKLRELYTTH KGNYGIPRDR SLVLC

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC088676 mRNA. Translation: AAH88676.1.
RefSeq	NP_001088871.1. NM_001095402.1.
UniGene	Xl.47003.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	496214.
KEGG	xla:496214.
Organism-specific databases
CTD	496214.
Xenbase	XB-GENE-6040390. mogat2.1.
Phylogenomic databases
HOVERGEN	HBG065791.
Family and domain databases
InterPro	IPR007130. DAGAT. [Graphical view]
PANTHER	PTHR12317. DAGAT. 1 hit.
Pfam	PF03982. DAGAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MOG2B_XENLA

Accession

Primary (citable) accession number: Q5M7F4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	February 1, 2005
Last modified:	May 31, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program