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Protein

CB1 cannabinoid receptor-interacting protein 1

Gene

Cnrip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.By similarity

GO - Molecular functioni

  • protein C-terminus binding Source: UniProtKB
  • type 1 cannabinoid receptor binding Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
CB1 cannabinoid receptor-interacting protein 1
Short name:
CRIP-1
Gene namesi
Name:Cnrip1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi1308373 Cnrip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000893631 – 164CB1 cannabinoid receptor-interacting protein 1Add BLAST164

Proteomic databases

PaxDbiQ5M7A7
PRIDEiQ5M7A7

PTM databases

iPTMnetiQ5M7A7
PhosphoSitePlusiQ5M7A7
SwissPalmiQ5M7A7

Expressioni

Gene expression databases

BgeeiENSRNOG00000005326
ExpressionAtlasiQ5M7A7 baseline and differential
GenevisibleiQ5M7A7 RN

Interactioni

Subunit structurei

Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.1 Publication

GO - Molecular functioni

  • protein C-terminus binding Source: UniProtKB
  • type 1 cannabinoid receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi264650, 1 interactor
STRINGi10116.ENSRNOP00000007104

Family & Domainsi

Sequence similaritiesi

Belongs to the CNRIP family.Curated

Phylogenomic databases

eggNOGiENOG410IK8D Eukaryota
ENOG41123ZA LUCA
GeneTreeiENSGT00390000004284
HOGENOMiHOG000089982
HOVERGENiHBG056498
InParanoidiQ5M7A7
OMAiRQPIQVN
OrthoDBiEOG091G0QCP

Family and domain databases

InterProiView protein in InterPro
IPR029204 CNRIP1
PANTHERiPTHR31952 PTHR31952, 1 hit
PfamiView protein in Pfam
PF15043 CNRIP1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5M7A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDLPGIVRL SIALRIQPND GPVFFKVDGQ RFGQNRTIKL LTGSSYKVEV
60 70 80 90 100
KIKPTTLQVE NISIGGVLVP LELKCKEPDG ERVVYTGIYD TEGVAPTKSG
110 120 130 140 150
ERQPIQITMP FTDIGTFETV WQVKFYNYHK RDHCQWGSPF SVIEYECKPN
160
ETRSLMWVNK ESFL
Length:164
Mass (Da):18,658
Last modified:February 1, 2005 - v1
Checksum:iB3190F0D633CEEE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY883936 mRNA Translation: AAX68416.1
BC088754 mRNA Translation: AAH88754.1
RefSeqiNP_001014254.1, NM_001014232.1
UniGeneiRn.8173

Genome annotation databases

EnsembliENSRNOT00000007104; ENSRNOP00000007104; ENSRNOG00000005326
GeneIDi364208
KEGGirno:364208
UCSCiRGD:1308373 rat

Similar proteinsi

Entry informationi

Entry nameiCNRP1_RAT
AccessioniPrimary (citable) accession number: Q5M7A7
Secondary accession number(s): A2RQR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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