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Protein

CB1 cannabinoid receptor-interacting protein 1

Gene

Cnrip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
CB1 cannabinoid receptor-interacting protein 1
Short name:
CRIP-1
Gene namesi
Name:Cnrip1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1308373. Cnrip1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 164164CB1 cannabinoid receptor-interacting protein 1PRO_0000089363Add
BLAST

Proteomic databases

PaxDbiQ5M7A7.
PRIDEiQ5M7A7.

PTM databases

iPTMnetiQ5M7A7.
PhosphoSiteiQ5M7A7.
SwissPalmiQ5M7A7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000005326.
ExpressionAtlasiQ5M7A7. baseline and differential.
GenevisibleiQ5M7A7. RN.

Interactioni

Subunit structurei

Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.1 Publication

Protein-protein interaction databases

BioGridi264650. 1 interaction.
STRINGi10116.ENSRNOP00000007104.

Family & Domainsi

Sequence similaritiesi

Belongs to the CNRIP family.Curated

Phylogenomic databases

eggNOGiENOG410IK8D. Eukaryota.
ENOG41123ZA. LUCA.
GeneTreeiENSGT00390000004284.
HOGENOMiHOG000089982.
HOVERGENiHBG056498.
InParanoidiQ5M7A7.
OMAiRQPIQVN.
OrthoDBiEOG091G0QCP.

Family and domain databases

InterProiIPR029204. CNRIP1.
[Graphical view]
PfamiPF15043. CNRIP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M7A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDLPGIVRL SIALRIQPND GPVFFKVDGQ RFGQNRTIKL LTGSSYKVEV
60 70 80 90 100
KIKPTTLQVE NISIGGVLVP LELKCKEPDG ERVVYTGIYD TEGVAPTKSG
110 120 130 140 150
ERQPIQITMP FTDIGTFETV WQVKFYNYHK RDHCQWGSPF SVIEYECKPN
160
ETRSLMWVNK ESFL
Length:164
Mass (Da):18,658
Last modified:February 1, 2005 - v1
Checksum:iB3190F0D633CEEE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY883936 mRNA. Translation: AAX68416.1.
BC088754 mRNA. Translation: AAH88754.1.
RefSeqiNP_001014254.1. NM_001014232.1.
UniGeneiRn.8173.

Genome annotation databases

EnsembliENSRNOT00000007104; ENSRNOP00000007104; ENSRNOG00000005326.
GeneIDi364208.
KEGGirno:364208.
UCSCiRGD:1308373. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY883936 mRNA. Translation: AAX68416.1.
BC088754 mRNA. Translation: AAH88754.1.
RefSeqiNP_001014254.1. NM_001014232.1.
UniGeneiRn.8173.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi264650. 1 interaction.
STRINGi10116.ENSRNOP00000007104.

PTM databases

iPTMnetiQ5M7A7.
PhosphoSiteiQ5M7A7.
SwissPalmiQ5M7A7.

Proteomic databases

PaxDbiQ5M7A7.
PRIDEiQ5M7A7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007104; ENSRNOP00000007104; ENSRNOG00000005326.
GeneIDi364208.
KEGGirno:364208.
UCSCiRGD:1308373. rat.

Organism-specific databases

CTDi25927.
RGDi1308373. Cnrip1.

Phylogenomic databases

eggNOGiENOG410IK8D. Eukaryota.
ENOG41123ZA. LUCA.
GeneTreeiENSGT00390000004284.
HOGENOMiHOG000089982.
HOVERGENiHBG056498.
InParanoidiQ5M7A7.
OMAiRQPIQVN.
OrthoDBiEOG091G0QCP.

Miscellaneous databases

PROiQ5M7A7.

Gene expression databases

BgeeiENSRNOG00000005326.
ExpressionAtlasiQ5M7A7. baseline and differential.
GenevisibleiQ5M7A7. RN.

Family and domain databases

InterProiIPR029204. CNRIP1.
[Graphical view]
PfamiPF15043. CNRIP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNRP1_RAT
AccessioniPrimary (citable) accession number: Q5M7A7
Secondary accession number(s): A2RQR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: February 1, 2005
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.