Reviewed, UniProtKB/Swiss-Prot Q5M775 (SPEC1_HUMAN)

Names and origin

Protein names

Recommended name:
    Sperm antigen with calponin homology and coiled-coil domains 1
Alternative name(s):
    Nuclear structure protein 5
      Short name=NSP5
    Sperm antigen HCMOGT-1

Gene names

Name:	SPECC1
Synonyms:	NSP5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1068 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Nucleus. Ref.2
Tissue specificity	Highly expressed in testis. Barely detectable in other tissues. Also highly expressed in some cancer cell lines. Ref.2
Involvement in disease	A chromosomal aberration involving SPECC1 may be a cause of juvenile myelomonocytic leukemia. Translocation t(5;17)(q33;p11.2) with PDGFRB.
Sequence similarities	Belongs to the cytospin-A family. Contains 1 CH (calponin-homology) domain.
Sequence caution	The sequence BAB16440.1 differs from that shown. Reason: Frameshift at position 8.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Disease	Proto-oncogene
Domain	Coiled coil
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5M775-1)

Also known as: NSP5beta3beta;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5M775-2)

Also known as: NSP5beta3alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     785-790: PVDEEP → SLGSVS
     791-1068: Missing.

Isoform 3 (identifier: Q5M775-3)

Also known as: NSP5alpha3alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: MRSAAKPWNP...LTESRLRSGT → MGNHSGRPEDPEP
     785-790: PVDEEP → SLGSVS
     791-1068: Missing.

Isoform 4 (identifier: Q5M775-4)

Also known as: NSP5alpha3beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: MRSAAKPWNP...LTESRLRSGT → MGNHSGRPEDPEP

Isoform 5 (identifier: Q5M775-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: MRSAAKPWNP...LTESRLRSGT → MGNHSGRPEDPEP
     785-1068: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1068	1068	Sperm antigen with calponin homology and coiled-coil domains 1		PRO_0000254033
Regions
	Domain	962 – 1064	103	CH
	Coiled coil	579 – 773	195	Potential
	Compositional bias	260 – 372	113	Ser-rich
Amino acid modifications
	Modified residue	112	1	Phosphoserine By similarity
	Modified residue	120	1	Phosphoserine By similarity
	Modified residue	131	1	Phosphoserine Ref.8
	Modified residue	134	1	Phosphoserine Ref.8
	Modified residue	138	1	Phosphoserine Ref.8
	Modified residue	142	1	Phosphothreonine Ref.8
	Modified residue	218	1	Phosphoserine Ref.8
	Modified residue	360	1	Phosphoserine Ref.6
	Modified residue	361	1	Phosphoserine Ref.6
	Modified residue	366	1	Phosphoserine Ref.6
	Modified residue	847	1	Phosphoserine Ref.8 Ref.7
	Modified residue	863	1	Phosphoserine Ref.8
	Modified residue	912	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	1 – 94	94	MRSAA…LRSGT → MGNHSGRPEDPEP in isoform 3, isoform 4 and isoform 5.		VSP_021162
	Alternative sequence	785 – 1068	284	Missing in isoform 5.		VSP_021163
	Alternative sequence	785 – 790	6	PVDEEP → SLGSVS in isoform 2 and isoform 3.		VSP_021164
	Alternative sequence	791 – 1068	278	Missing in isoform 2 and isoform 3.		VSP_021165
	Natural variant	274	1	S → R: dbSNP rs9908032. Ref.1		VAR_053055
	Natural variant	293	1	M → L: dbSNP rs2703806. Ref.2 Ref.1 Ref.3 Ref.4		VAR_028800
	Natural variant	769	1	D → N: dbSNP rs35835131.		VAR_053056
Experimental info
	Sequence conflict	164 – 170	7	AALESQV → VRLSPKF in BAB16440. Ref.1
	Sequence conflict	179	1	A → S in BAB16440. Ref.1
	Sequence conflict	179	1	A → S in AAW30001. Ref.2
	Sequence conflict	330	1	D → N in AAH50058. Ref.4
	Sequence conflict	359	1	G → R in AAH50058. Ref.4
	Sequence conflict	364	1	S → I in AAH33618. Ref.4
	Sequence conflict	382	1	E → G in AAW29999. Ref.2
	Sequence conflict	382	1	E → G in AAW30000. Ref.2
	Sequence conflict	382	1	E → G in AAW30002. Ref.2
	Sequence conflict	434 – 435	2	EQ → DE in AAH50058. Ref.4
	Sequence conflict	831	1	R → G in AAW30000. Ref.2
	Sequence conflict	831	1	R → G in AAW30002. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (NSP5beta3beta) [UniParc]. Last modified February 1, 2005. Version 1. Checksum: E6FB6987C835A1CA	FASTA	1,068	118,585
	10 20 30 40 50 60 MRSAAKPWNP AIRAGGHGPD RVRPLPAASS GMKSSKSSTS LAFESRLSRL KRASSEDTLN 70 80 90 100 110 120 KPGSTAASGV VRLKKTATAG AISELTESRL RSGTGAFTTT KRTGIPAPRE FSVTVSRERS 130 140 150 160 170 180 VPRGPSNPRK SVSSPTSSNT PTPTKHLRTP STKPKQENEG GEKAALESQV RELLAEAKAK 190 200 210 220 230 240 DSEINRLRSE LKKYKEKRTL NAEGTDALGP NVDGTSVSPG DTEPMIRALE EKNKNFQKEL 250 260 270 280 290 300 SDLEEENRVL KEKLIYLEHS PNSEGAASHT GDSSCPTSIT QESSFGSPTG NQMSSDIDEY 310 320 330 340 350 360 KKNIHGNALR TSGSSSSDVT KASLSPDASD FEHITAETPS RPLSSTSNPF KSSKCSTAGS 370 380 390 400 410 420 SPNSVSELSL ASLTEKIQKM EENHHSTAEE LQATLQELSD QQQMVQELTA ENEKLVDEKT 430 440 450 460 470 480 ILETSFHQHR ERAEQLSQEN EKLMNLLQER VKNEEPTTQE GKIIELEQKC TGILEQGRFE 490 500 510 520 530 540 REKLLNIQQQ LTCSLRKVEE ENQGALEMIK RLKEENEKLN EFLELERHNN NMMAKTLEEC 550 560 570 580 590 600 RVTLEGLKME NGSLKSHLQG EKQKATEASA VEQTAESCEV QEMLKVARAE KDLLELSCNE 610 620 630 640 650 660 LRQELLKANG EIKHVSSLLA KVEKDYSYLK EICDHQAEQL SRTSLKLQEK ASESDAEIKD 670 680 690 700 710 720 MKETIFELED QVEQHRAVKL HNNQLISELE SSVIKLEEQK SDLERQLKTL TKQMKEETEE 730 740 750 760 770 780 WRRFQADLQT AVVVANDIKC EAQQELRTVK RKLLEEEEKN ARLQKELGDV QGHGRVVTSR 790 800 810 820 830 840 AAPPPVDEEP ESSEVDAAGR WPGVCVSRTS PTPPESATTV KSLIKSFDLG RPGGAGQNIS 850 860 870 880 890 900 VHKTPRSPLS GIPVRTAPAA AVSPMQRHST YSSVRPASRG VTQRLDLPDL PLSDILKGRT 910 920 930 940 950 960 ETLKPDPHLR KSPSLESLSR PPSLGFGDTR LLSASTRAWK PQSKLSVERK DPLAALAREY 970 980 990 1000 1010 1020 GGSKRNALLK WCQKKTQGYA NIDITNFSSS WSDGLAFCAL LHTYLPAHIP YQELNSQEKK 1030 1040 1050 1060 RNLLLAFEAA ESVGIKPSLE LSEMLYTDRP DWQSVMQYVA QIYKYFET
	Isoform 2 (NSP5beta3alpha). Checksum: EBA37084509E44BF	FASTA	790	87,888
	10 20 30 40 50 60 MRSAAKPWNP AIRAGGHGPD RVRPLPAASS GMKSSKSSTS LAFESRLSRL KRASSEDTLN 70 80 90 100 110 120 KPGSTAASGV VRLKKTATAG AISELTESRL RSGTGAFTTT KRTGIPAPRE FSVTVSRERS 130 140 150 160 170 180 VPRGPSNPRK SVSSPTSSNT PTPTKHLRTP STKPKQENEG GEKAALESQV RELLAEAKAK 190 200 210 220 230 240 DSEINRLRSE LKKYKEKRTL NAEGTDALGP NVDGTSVSPG DTEPMIRALE EKNKNFQKEL 250 260 270 280 290 300 SDLEEENRVL KEKLIYLEHS PNSEGAASHT GDSSCPTSIT QESSFGSPTG NQMSSDIDEY 310 320 330 340 350 360 KKNIHGNALR TSGSSSSDVT KASLSPDASD FEHITAETPS RPLSSTSNPF KSSKCSTAGS 370 380 390 400 410 420 SPNSVSELSL ASLTEKIQKM EENHHSTAEE LQATLQELSD QQQMVQELTA ENEKLVDEKT 430 440 450 460 470 480 ILETSFHQHR ERAEQLSQEN EKLMNLLQER VKNEEPTTQE GKIIELEQKC TGILEQGRFE 490 500 510 520 530 540 REKLLNIQQQ LTCSLRKVEE ENQGALEMIK RLKEENEKLN EFLELERHNN NMMAKTLEEC 550 560 570 580 590 600 RVTLEGLKME NGSLKSHLQG EKQKATEASA VEQTAESCEV QEMLKVARAE KDLLELSCNE 610 620 630 640 650 660 LRQELLKANG EIKHVSSLLA KVEKDYSYLK EICDHQAEQL SRTSLKLQEK ASESDAEIKD 670 680 690 700 710 720 MKETIFELED QVEQHRAVKL HNNQLISELE SSVIKLEEQK SDLERQLKTL TKQMKEETEE 730 740 750 760 770 780 WRRFQADLQT AVVVANDIKC EAQQELRTVK RKLLEEEEKN ARLQKELGDV QGHGRVVTSR 790 AAPPSLGSVS
	Isoform 3 (NSP5alpha3alpha). Checksum: B381B7FE6D6AF509	FASTA	709	79,546
	10 20 30 40 50 60 MGNHSGRPED PEPGAFTTTK RTGIPAPREF SVTVSRERSV PRGPSNPRKS VSSPTSSNTP 70 80 90 100 110 120 TPTKHLRTPS TKPKQENEGG EKAALESQVR ELLAEAKAKD SEINRLRSEL KKYKEKRTLN 130 140 150 160 170 180 AEGTDALGPN VDGTSVSPGD TEPMIRALEE KNKNFQKELS DLEEENRVLK EKLIYLEHSP 190 200 210 220 230 240 NSEGAASHTG DSSCPTSITQ ESSFGSPTGN QMSSDIDEYK KNIHGNALRT SGSSSSDVTK 250 260 270 280 290 300 ASLSPDASDF EHITAETPSR PLSSTSNPFK SSKCSTAGSS PNSVSELSLA SLTEKIQKME 310 320 330 340 350 360 ENHHSTAEEL QATLQELSDQ QQMVQELTAE NEKLVDEKTI LETSFHQHRE RAEQLSQENE 370 380 390 400 410 420 KLMNLLQERV KNEEPTTQEG KIIELEQKCT GILEQGRFER EKLLNIQQQL TCSLRKVEEE 430 440 450 460 470 480 NQGALEMIKR LKEENEKLNE FLELERHNNN MMAKTLEECR VTLEGLKMEN GSLKSHLQGE 490 500 510 520 530 540 KQKATEASAV EQTAESCEVQ EMLKVARAEK DLLELSCNEL RQELLKANGE IKHVSSLLAK 550 560 570 580 590 600 VEKDYSYLKE ICDHQAEQLS RTSLKLQEKA SESDAEIKDM KETIFELEDQ VEQHRAVKLH 610 620 630 640 650 660 NNQLISELES SVIKLEEQKS DLERQLKTLT KQMKEETEEW RRFQADLQTA VVVANDIKCE 670 680 690 700 AQQELRTVKR KLLEEEEKNA RLQKELGDVQ GHGRVVTSRA APPSLGSVS
	Isoform 4 (NSP5alpha3beta). Checksum: AC1AB9E2C3C29B8B	FASTA	987	110,242
	10 20 30 40 50 60 MGNHSGRPED PEPGAFTTTK RTGIPAPREF SVTVSRERSV PRGPSNPRKS VSSPTSSNTP 70 80 90 100 110 120 TPTKHLRTPS TKPKQENEGG EKAALESQVR ELLAEAKAKD SEINRLRSEL KKYKEKRTLN 130 140 150 160 170 180 AEGTDALGPN VDGTSVSPGD TEPMIRALEE KNKNFQKELS DLEEENRVLK EKLIYLEHSP 190 200 210 220 230 240 NSEGAASHTG DSSCPTSITQ ESSFGSPTGN QMSSDIDEYK KNIHGNALRT SGSSSSDVTK 250 260 270 280 290 300 ASLSPDASDF EHITAETPSR PLSSTSNPFK SSKCSTAGSS PNSVSELSLA SLTEKIQKME 310 320 330 340 350 360 ENHHSTAEEL QATLQELSDQ QQMVQELTAE NEKLVDEKTI LETSFHQHRE RAEQLSQENE 370 380 390 400 410 420 KLMNLLQERV KNEEPTTQEG KIIELEQKCT GILEQGRFER EKLLNIQQQL TCSLRKVEEE 430 440 450 460 470 480 NQGALEMIKR LKEENEKLNE FLELERHNNN MMAKTLEECR VTLEGLKMEN GSLKSHLQGE 490 500 510 520 530 540 KQKATEASAV EQTAESCEVQ EMLKVARAEK DLLELSCNEL RQELLKANGE IKHVSSLLAK 550 560 570 580 590 600 VEKDYSYLKE ICDHQAEQLS RTSLKLQEKA SESDAEIKDM KETIFELEDQ VEQHRAVKLH 610 620 630 640 650 660 NNQLISELES SVIKLEEQKS DLERQLKTLT KQMKEETEEW RRFQADLQTA VVVANDIKCE 670 680 690 700 710 720 AQQELRTVKR KLLEEEEKNA RLQKELGDVQ GHGRVVTSRA APPPVDEEPE SSEVDAAGRW 730 740 750 760 770 780 PGVCVSRTSP TPPESATTVK SLIKSFDLGR PGGAGQNISV HKTPRSPLSG IPVRTAPAAA 790 800 810 820 830 840 VSPMQRHSTY SSVRPASRGV TQRLDLPDLP LSDILKGRTE TLKPDPHLRK SPSLESLSRP 850 860 870 880 890 900 PSLGFGDTRL LSASTRAWKP QSKLSVERKD PLAALAREYG GSKRNALLKW CQKKTQGYAN 910 920 930 940 950 960 IDITNFSSSW SDGLAFCALL HTYLPAHIPY QELNSQEKKR NLLLAFEAAE SVGIKPSLEL 970 980 SEMLYTDRPD WQSVMQYVAQ IYKYFET
	Isoform 5. Checksum: 150996E18DC39F99	FASTA	703	79,015
	10 20 30 40 50 60 MGNHSGRPED PEPGAFTTTK RTGIPAPREF SVTVSRERSV PRGPSNPRKS VSSPTSSNTP 70 80 90 100 110 120 TPTKHLRTPS TKPKQENEGG EKAALESQVR ELLAEAKAKD SEINRLRSEL KKYKEKRTLN 130 140 150 160 170 180 AEGTDALGPN VDGTSVSPGD TEPMIRALEE KNKNFQKELS DLEEENRVLK EKLIYLEHSP 190 200 210 220 230 240 NSEGAASHTG DSSCPTSITQ ESSFGSPTGN QMSSDIDEYK KNIHGNALRT SGSSSSDVTK 250 260 270 280 290 300 ASLSPDASDF EHITAETPSR PLSSTSNPFK SSKCSTAGSS PNSVSELSLA SLTEKIQKME 310 320 330 340 350 360 ENHHSTAEEL QATLQELSDQ QQMVQELTAE NEKLVDEKTI LETSFHQHRE RAEQLSQENE 370 380 390 400 410 420 KLMNLLQERV KNEEPTTQEG KIIELEQKCT GILEQGRFER EKLLNIQQQL TCSLRKVEEE 430 440 450 460 470 480 NQGALEMIKR LKEENEKLNE FLELERHNNN MMAKTLEECR VTLEGLKMEN GSLKSHLQGE 490 500 510 520 530 540 KQKATEASAV EQTAESCEVQ EMLKVARAEK DLLELSCNEL RQELLKANGE IKHVSSLLAK 550 560 570 580 590 600 VEKDYSYLKE ICDHQAEQLS RTSLKLQEKA SESDAEIKDM KETIFELEDQ VEQHRAVKLH 610 620 630 640 650 660 NNQLISELES SVIKLEEQKS DLERQLKTLT KQMKEETEEW RRFQADLQTA VVVANDIKCE 670 680 690 700 AQQELRTVKR KLLEEEEKNA RLQKELGDVQ GHGRVVTSRA APP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Komori S. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS ARG-274 AND LEU-293. Tissue: Testis.
[2]	"A gene highly expressed in tumor cells encodes novel structure proteins." Sang N., Fath D.M., Giordano A. Oncogene 23:9438-9446(2004) [PubMed: 15602574] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANT LEU-293, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Testis.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-293. Tissue: Brain.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 4 AND 5), VARIANT LEU-293. Tissue: Brain, Skin and Testis.
[5]	"HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5;17)(q33;p11.2)." Morerio C., Acquila M., Rosanda C., Rapella A., Dufour C., Locatelli F., Maserati E., Pasquali F., Panarello C. Cancer Res. 64:2649-2651(2004) [PubMed: 15087372] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH PDGFRB.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360; SER-361 AND SER-366, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-847, MASS SPECTROMETRY.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131; SER-134; SER-138; THR-142; SER-218; SER-847; SER-863 AND SER-912, MASS SPECTROMETRY.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB041533 mRNA. Translation: BAB16440.1. Frameshift. AY816326 mRNA. Translation: AAW29999.1. AY816327 mRNA. Translation: AAW30000.1. AY816328 mRNA. Translation: AAW30001.1. AY816329 mRNA. Translation: AAW30002.1. BK005598 Genomic DNA. Translation: DAA05629.1. BK005598 Genomic DNA. Translation: DAA05630.1. BK005598 Genomic DNA. Translation: DAA05631.1. BK005598 Genomic DNA. Translation: DAA05632.1. AK295093 mRNA. Translation: BAG58132.1. BC021123 mRNA. Translation: AAH21123.2. BC033618 mRNA. Translation: AAH33618.1. Different initiation. BC050058 mRNA. Translation: AAH50058.1.
IPI	IPI00030738. IPI00291032. IPI00651629. IPI00651654. IPI00791003.
RefSeq	NP_001028725.1. NP_001028726.1. NP_001028727.1. NP_690868.3.
UniGene	Hs.431045
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q5M775.
Proteomic databases
PRIDE	Q5M775.
Genome annotation databases
Ensembl	ENSG00000128487. Homo sapiens. [Contig view]
GeneID	92521.
KEGG	hsa:92521.
Organism-specific databases
GeneCards	GC17P019854.
HGNC	HGNC:30615. SPECC1.
MIM	608793. gene.
PharmGKB	PA142670882.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q5M775.
OMA	Q5M775. AKDSEIN.
Gene expression databases
ArrayExpress	Q5M775.
Bgee	Q5M775.
Family and domain databases
InterPro	IPR001715. Calponin_act_bd. [Graphical view]
Gene3D	G3DSA:1.10.418.10. Calponin-homology. 1 hit.
Pfam	PF00307. CH. 1 hit. [Graphical view]
SMART	SM00033. CH. 1 hit. [Graphical view]
PROSITE	PS50021. CH. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	77778.
SOURCE	Search...

Entry information

Entry name

SPEC1_HUMAN

Accession

Primary (citable) accession number: Q5M775
Secondary accession number(s): B4DHH0 , Q5IBP1, Q5IBP2, Q5IBP3, Q5IBP4, Q5M772, Q5M773, Q5M774, Q86XT8, Q8N4U4, Q8WU84, Q9HCQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	February 1, 2005
Last modified:	June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)