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Protein

Vacuolar protein sorting-associated protein 22 homolog 1

Gene

VP22-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-ATH-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 22 homolog 1
Short name:
AtVPS22-1
Alternative name(s):
ESCRT-II complex subunit VPS22 homolog 1
Gene namesi
Name:VP22-1
Ordered Locus Names:At4g27040
ORF Names:F10M23.380
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G27040
TAIRilocus:2116357 AT4G27040

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003681911 – 250Vacuolar protein sorting-associated protein 22 homolog 1Add BLAST250

Proteomic databases

PaxDbiQ5M759

Expressioni

Gene expression databases

ExpressionAtlasiQ5M759 baseline and differential
GenevisibleiQ5M759 AT

Interactioni

Subunit structurei

Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of VPS22, VPS25 and VPS36.By similarity

Protein-protein interaction databases

BioGridi14099, 6 interactors
IntActiQ5M759, 5 interactors
STRINGi3702.AT4G27040.1

Structurei

3D structure databases

ProteinModelPortaliQ5M759
SMRiQ5M759
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili35 – 55Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 16Poly-Ala4

Sequence similaritiesi

Belongs to the SNF8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3341 Eukaryota
ENOG410XPVM LUCA
HOGENOMiHOG000170930
InParanoidiQ5M759
KOiK12188
OMAiQYWLPAL
OrthoDBiEOG09360KPO

Family and domain databases

Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR016689 ESCRT-2_cplx_Snf8
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12806 PTHR12806, 1 hit
PIRSFiPIRSF017215 ESCRT2_Vps22, 1 hit
SUPFAMiSSF46785 SSF46785, 2 hits

Sequencei

Sequence statusi: Complete.

Q5M759-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRRPGIGGL QKAAAARDQY RLLGENVAKL RTDMMKEQLS TFRSQLEEFA
60 70 80 90 100
RKHKNDIRKN PAFRAQFHEM CANIGVDPLA SNKGFWAELL GIGDFYYELG
110 120 130 140 150
VQIIEVCMLT RSHNGGLISL QELCNHLRQR RKKDREAVTE DDCLRAISKL
160 170 180 190 200
KVLGSGFEVI TIGKKKLVRS VPTELNKDHN QILELAQGQG FVIVEEVQRR
210 220 230 240 250
LSWTSGRVID ALETLLEEGL AMIDNGHKDG KCRYWFPCVS SVYSSIGSDT
Length:250
Mass (Da):28,310
Last modified:May 3, 2011 - v2
Checksum:i0BED008163F0C744
GO

Sequence cautioni

The sequence CAB36550 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB79559 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17R → G in AAV91335 (Ref. 4) Curated1
Sequence conflicti17R → G in AAW70398 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035440 Genomic DNA Translation: CAB36550.1 Sequence problems.
AL161566 Genomic DNA Translation: CAB79559.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE85287.1
CP002687 Genomic DNA Translation: AEE85288.1
CP002687 Genomic DNA Translation: AEE85289.1
CP002687 Genomic DNA Translation: AEE85290.1
CP002687 Genomic DNA Translation: ANM66725.1
CP002687 Genomic DNA Translation: ANM66726.1
AY299265 mRNA No translation available.
BT020389 mRNA Translation: AAV91335.1
BT020552 mRNA Translation: AAW70398.1
PIRiT04827
RefSeqiNP_001119065.1, NM_001125593.1
NP_001119066.1, NM_001125594.1
NP_001119067.1, NM_001125595.2
NP_001328603.1, NM_001341835.1
NP_001328604.1, NM_001341834.1
NP_194434.2, NM_118838.5
UniGeneiAt.48906
At.68943
At.68944
At.68945

Genome annotation databases

EnsemblPlantsiAT4G27040.1; AT4G27040.1; AT4G27040
AT4G27040.2; AT4G27040.2; AT4G27040
AT4G27040.3; AT4G27040.3; AT4G27040
AT4G27040.4; AT4G27040.4; AT4G27040
AT4G27040.5; AT4G27040.5; AT4G27040
AT4G27040.6; AT4G27040.6; AT4G27040
GeneIDi828812
GrameneiAT4G27040.1; AT4G27040.1; AT4G27040
AT4G27040.2; AT4G27040.2; AT4G27040
AT4G27040.3; AT4G27040.3; AT4G27040
AT4G27040.4; AT4G27040.4; AT4G27040
AT4G27040.5; AT4G27040.5; AT4G27040
AT4G27040.6; AT4G27040.6; AT4G27040
KEGGiath:AT4G27040

Similar proteinsi

Entry informationi

Entry nameiVP221_ARATH
AccessioniPrimary (citable) accession number: Q5M759
Secondary accession number(s): Q9SZ43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 3, 2011
Last modified: April 25, 2018
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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