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Q5M6J5

- PUR5_STRT2

UniProt

Q5M6J5 - PUR5_STRT2

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, stu0033
Organism
Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTHE264199:GI6K-54-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:stu0033
OrganismiStreptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Taxonomic identifieri264199 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001170: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_0000258418Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264199.stu0033.

Structurei

3D structure databases

ProteinModelPortaliQ5M6J5.
SMRiQ5M6J5. Positions 14-335.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5M6J5-1 [UniParc]FASTAAdd to Basket

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MSKNAYAQSG VDVEAGYEVV ERIKKHVART ERAGVMGGLG GFGGMFDLSK    50
TGVKEPVLIS GTDGVGTKLM LAIKYDKHDT IGQDCVAMCV NDIIAAGAEP 100
LYFLDYVATG KNEPAKLEQV IAGVAEGCVQ SGVALIGGET AEMPGMYGED 150
DYDLAGFAVG VAEKSQIIDG SKVAEGDVLL GLASSGIHSN GYSLVRRVFA 200
DYTGEEVLPE LEGQKLKDVL LEPTRIYVKA ALPLIKEELV NGIAHITGGG 250
FIENVPRMFS DDLAAEIDES KVPVLPIFKA LEKYGEIKHE EMFEIFNMGI 300
GLMFAVKPEN VERVKELLDE PVYEIGRIVK KDGASVVIK 339
Length:339
Mass (Da):36,337
Last modified:February 1, 2005 - v1
Checksum:i8DF0565D886518B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000023 Genomic DNA. Translation: AAV59763.1.
RefSeqiYP_138578.1. NC_006448.1.

Genome annotation databases

EnsemblBacteriaiAAV59763; AAV59763; stu0033.
GeneIDi3163831.
KEGGistl:stu0033.
PATRICi19801556. VBIStrThe97850_0035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000023 Genomic DNA. Translation: AAV59763.1 .
RefSeqi YP_138578.1. NC_006448.1.

3D structure databases

ProteinModelPortali Q5M6J5.
SMRi Q5M6J5. Positions 14-335.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264199.stu0033.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV59763 ; AAV59763 ; stu0033 .
GeneIDi 3163831.
KEGGi stl:stu0033.
PATRICi 19801556. VBIStrThe97850_0035.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci STHE264199:GI6K-54-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-250 / LMG 18311.

Entry informationi

Entry nameiPUR5_STRT2
AccessioniPrimary (citable) accession number: Q5M6J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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