Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Arginine--tRNA ligase

Gene

argS

Organism
Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTHE264199:GI6K-68-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:stu0047
OrganismiStreptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Taxonomic identifieri264199 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001170: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Arginine--tRNA ligasePRO_0000242101Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi264199.stu0047.

Structurei

3D structure databases

ProteinModelPortaliQ5M6I4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi121 – 13111"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247211.
KOiK01887.
OMAiNPNGPLH.
OrthoDBiEOG6JB13C.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5M6I4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTKELIAAE IAKVVPELEQ ENIQNLLEIP KNADMGDLAF PAFSLAKVLR
60 70 80 90 100
KAPQMIAADI AEKIDASNFE KVEAVGPYIN IFLDKSKISA DVLGQVIAQG
110 120 130 140 150
SHYADQNIGN GRNIAFDMSS PNIAKPFSIG HLRSTVIADA LANIVAKQGY
160 170 180 190 200
KPVRINHLGD WGKQFGMLIV AYKKWGSEEA VKANPINELL QLYVRINAEA
210 220 230 240 250
EEDPSVDEEA REWFRKLEAG DEEATALWQW FRDESLVEFN RLYDELGVSF
260 270 280 290 300
DSYNGEAFYN DKMDEVVDIL TKKGLLQESQ GAQVVNLEKY GIEHPALIKK
310 320 330 340 350
SDGATLYITR DLAAALYRKR TYDFAKAIYV VGNEQSAHFK QLKAVLKEMG
360 370 380 390 400
YNWSDDMTHV AFGLVTKNGK KLSTRKGNVI LLEPTIAEAV NRAQAQIEAK
410 420 430 440 450
NPNLPNKEAI AHAVGVGAIK FYDLKTDRMN GYDFDLDAMV SFEGETGPYV
460 470 480 490 500
QYAHARIQSI LRKADFTPSA DATYSLNDVE SWEIIKLLQD FPRIINRASD
510 520 530 540 550
NFEPSIVAKF AISLAQAFNK YYAHTRILDE SPERDSRLAL CYATATVLKE
560
ALRLLGVEAP DEM
Length:563
Mass (Da):62,892
Last modified:February 1, 2005 - v1
Checksum:i3E7C200F1058C816
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000023 Genomic DNA. Translation: AAV59777.1.
RefSeqiYP_138592.1. NC_006448.1.

Genome annotation databases

EnsemblBacteriaiAAV59777; AAV59777; stu0047.
GeneIDi3164079.
KEGGistl:stu0047.
PATRICi19801584. VBIStrThe97850_0049.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000023 Genomic DNA. Translation: AAV59777.1.
RefSeqiYP_138592.1. NC_006448.1.

3D structure databases

ProteinModelPortaliQ5M6I4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264199.stu0047.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV59777; AAV59777; stu0047.
GeneIDi3164079.
KEGGistl:stu0047.
PATRICi19801584. VBIStrThe97850_0049.

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247211.
KOiK01887.
OMAiNPNGPLH.
OrthoDBiEOG6JB13C.

Enzyme and pathway databases

BioCyciSTHE264199:GI6K-68-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-250 / LMG 18311.

Entry informationi

Entry nameiSYR_STRT2
AccessioniPrimary (citable) accession number: Q5M6I4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: February 1, 2005
Last modified: February 4, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.