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Q5M6A1 (UPPP_STRT2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA
Ordered Locus Names:stu0160
OrganismStreptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) [Complete proteome] [HAMAP]
Taxonomic identifier264199 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151221

Regions

Transmembrane25 – 4521Helical; Potential
Transmembrane53 – 7321Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane121 – 14121Helical; Potential
Transmembrane171 – 19121Helical; Potential
Transmembrane196 – 21621Helical; Potential
Transmembrane231 – 25121Helical; Potential
Transmembrane263 – 28321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q5M6A1 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: AE9FE7DE0AD428EE

FASTA28832,283
        10         20         30         40         50         60 
MEIIMQTAQY IIELLKAVFL GIVEGITEWL PISSTGHLIL VNEFLNLRQS KDFIDMFNIV 

        70         80         90        100        110        120 
IQLGAILAVM VIYFKRLNPF QPGKTAREVQ LTWKLWLKVV IACIPSAFFG LLLDDWMEAH 

       130        140        150        160        170        180 
LSNFFVVAIM LVVYGIAFIW IEDRNRRVDP KVTDLARMSY KTAFYIGLFQ VLSIIPGTSR 

       190        200        210        220        230        240 
SGATILGGII VGTSRSVAAD FTFFLGIPTM FGYSGLKAVK YFIDGNTLTG GQAAILLVAS 

       250        260        270        280 
VTAFLVSLFV IRFLMNYIKK HDFTVFGKYR IVLGIIVLFY GAVKLIFG 

« Hide

References

[1]"Complete sequence and comparative genome analysis of the dairy bacterium Streptococcus thermophilus."
Bolotin A., Quinquis B., Renault P., Sorokin A., Ehrlich S.D., Kulakauskas S., Lapidus A., Goltsman E., Mazur M., Pusch G.D., Fonstein M., Overbeek R., Kyprides N., Purnelle B., Prozzi D., Ngui K., Masuy D., Hancy F. expand/collapse author list , Burteau S., Boutry M., Delcour J., Goffeau A., Hols P.
Nat. Biotechnol. 22:1554-1558(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-250 / LMG 18311.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000023 Genomic DNA. Translation: AAV59885.1.
RefSeqYP_138700.1. NC_006448.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING264199.stu0160.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV59885; AAV59885; stu0160.
GeneID3165178.
KEGGstl:stu0160.
PATRIC19801890. VBIStrThe97850_0167.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycSTHE264199:GI6K-211-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_STRT2
AccessionPrimary (citable) accession number: Q5M6A1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: February 1, 2005
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families