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Q5M6A1

- UPPP_STRT2

UniProt

Q5M6A1 - UPPP_STRT2

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciSTHE264199:GI6K-211-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Synonyms:bacA
    Ordered Locus Names:stu0160
    OrganismiStreptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
    Taxonomic identifieri264199 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001170: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Undecaprenyl-diphosphatasePRO_0000151221Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi264199.stu0160.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521HelicalUniRule annotationAdd
    BLAST
    Transmembranei53 – 7321HelicalUniRule annotationAdd
    BLAST
    Transmembranei93 – 11321HelicalUniRule annotationAdd
    BLAST
    Transmembranei121 – 14121HelicalUniRule annotationAdd
    BLAST
    Transmembranei171 – 19121HelicalUniRule annotationAdd
    BLAST
    Transmembranei196 – 21621HelicalUniRule annotationAdd
    BLAST
    Transmembranei231 – 25121HelicalUniRule annotationAdd
    BLAST
    Transmembranei263 – 28321HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5M6A1-1 [UniParc]FASTAAdd to Basket

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    MEIIMQTAQY IIELLKAVFL GIVEGITEWL PISSTGHLIL VNEFLNLRQS    50
    KDFIDMFNIV IQLGAILAVM VIYFKRLNPF QPGKTAREVQ LTWKLWLKVV 100
    IACIPSAFFG LLLDDWMEAH LSNFFVVAIM LVVYGIAFIW IEDRNRRVDP 150
    KVTDLARMSY KTAFYIGLFQ VLSIIPGTSR SGATILGGII VGTSRSVAAD 200
    FTFFLGIPTM FGYSGLKAVK YFIDGNTLTG GQAAILLVAS VTAFLVSLFV 250
    IRFLMNYIKK HDFTVFGKYR IVLGIIVLFY GAVKLIFG 288
    Length:288
    Mass (Da):32,283
    Last modified:February 1, 2005 - v1
    Checksum:iAE9FE7DE0AD428EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000023 Genomic DNA. Translation: AAV59885.1.
    RefSeqiYP_138700.1. NC_006448.1.

    Genome annotation databases

    EnsemblBacteriaiAAV59885; AAV59885; stu0160.
    GeneIDi3165178.
    KEGGistl:stu0160.
    PATRICi19801890. VBIStrThe97850_0167.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000023 Genomic DNA. Translation: AAV59885.1 .
    RefSeqi YP_138700.1. NC_006448.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264199.stu0160.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV59885 ; AAV59885 ; stu0160 .
    GeneIDi 3165178.
    KEGGi stl:stu0160.
    PATRICi 19801890. VBIStrThe97850_0167.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci STHE264199:GI6K-211-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-250 / LMG 18311.

    Entry informationi

    Entry nameiUPPP_STRT2
    AccessioniPrimary (citable) accession number: Q5M6A1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3