Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5M657

- SYL_STRT2

UniProt

Q5M657 - SYL_STRT2

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei613 – 6131ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTHE264199:GI6K-271-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:stu0220
OrganismiStreptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Taxonomic identifieri264199 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001170: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 833833Leucine--tRNA ligasePRO_1000009451Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264199.stu0220.

Structurei

3D structure databases

ProteinModelPortaliQ5M657.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5212"HIGH" regionAdd
BLAST
Motifi610 – 6145"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M657-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFYNHKEIE PKWQKYWADH HTFKTGTDAS KPKFYALDMF PYPSGAGLHV
60 70 80 90 100
GHPEGYTATD ILSRFKRAQG YNVLHPMGWD AFGLPAEQYA MDTGNDPADF
110 120 130 140 150
TAENIANFKR QINALGFSYD WDREINTTDP NYYKWTQWIF TKLYEKGLAY
160 170 180 190 200
EAEVPVNWVE ELGTAIANEE VLPDGTSERG GYPVVRKPMR QWMLKITAYA
210 220 230 240 250
ERLLNDLDEL DWPESIKDMQ RNWIGKSTGA NVTFKVKGTD KEFTVFTTRP
260 270 280 290 300
DTLFGATFTV LAPEHDLVDA ITSPEQAEAV ANYKHQASLK SDLARTDLAK
310 320 330 340 350
EKTGVWTGAY AINPVNGREI PIWIADYVLA SYGTGAVMAV PAHDERDWEF
360 370 380 390 400
AKQFGLPIVE VLEGGNVEEA AYTEDGPHVN SDFLNGLNKE EAIAKIVAWL
410 420 430 440 450
EEKGFGQEKI TYRLRDWLFS RQRYWGEPIP IIHWEDGTST AVPESELPLV
460 470 480 490 500
LPVTKDIRPS GTGESPLANL TDWLEVTRED GVKGRRETNT MPQWAGSSWY
510 520 530 540 550
YLRYIDPHNT EKLADEDLLK QWLPVDIYVG GAEHAVLHLL YARFWHKFLY
560 570 580 590 600
DLGVVPTKEP FQKLFNQGMI LGTSYRDHRG ALVATDKVEK RDGSFFHVET
610 620 630 640 650
GEELEQAPAK MSKSLKNVVN PDDVVEQYGA DTLRVYEMFM GPLDASIAWS
660 670 680 690 700
EEGLEGSRKF LDRVYRLITS KEIVAENNGG LDKVYNETVK SVTEQIELMK
710 720 730 740 750
FNTAIAQLMV FVNAANKEDK LYVDYAKGFV QLIAPFAPHL AEELWQTLTA
760 770 780 790 800
TGESISYVAW PTWDESKLVE DEIEIVVQIK GKVRAKLMVA KDLSREELQE
810 820 830
VALADEKVKA EIDGKEIVKV IAVPNKLVNI VVK
Length:833
Mass (Da):94,422
Last modified:February 1, 2005 - v1
Checksum:i44462D3B0B2BE70B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000023 Genomic DNA. Translation: AAV59945.1.
RefSeqiYP_138760.1. NC_006448.1.

Genome annotation databases

EnsemblBacteriaiAAV59945; AAV59945; stu0220.
GeneIDi3164502.
KEGGistl:stu0220.
PATRICi19802012. VBIStrThe97850_0228.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000023 Genomic DNA. Translation: AAV59945.1 .
RefSeqi YP_138760.1. NC_006448.1.

3D structure databases

ProteinModelPortali Q5M657.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264199.stu0220.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV59945 ; AAV59945 ; stu0220 .
GeneIDi 3164502.
KEGGi stl:stu0220.
PATRICi 19802012. VBIStrThe97850_0228.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci STHE264199:GI6K-271-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-250 / LMG 18311.

Entry informationi

Entry nameiSYL_STRT2
AccessioniPrimary (citable) accession number: Q5M657
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 1, 2005
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3