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Protein

Elongation factor Tu

Gene

tuf

Organism
Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 26GTPUniRule annotation8
Nucleotide bindingi84 – 88GTPUniRule annotation5
Nucleotide bindingi139 – 142GTPUniRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tufUniRule annotation
Ordered Locus Names:stu0487
OrganismiStreptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Taxonomic identifieri264199 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001170 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000157621 – 398Elongation factor TuAdd BLAST398

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi264199.stu0487

Structurei

3D structure databases

ProteinModelPortaliQ5M5I8
SMRiQ5M5I8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 207tr-type GAdd BLAST198

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 26G1By similarity8
Regioni63 – 67G2By similarity5
Regioni84 – 87G3By similarity4
Regioni139 – 142G4By similarity4
Regioni177 – 179G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGV Bacteria
COG0050 LUCA
HOGENOMiHOG000229290
KOiK02358
OMAiAIRDMGM

Family and domain databases

CDDicd03697 EFTU_II, 1 hit
HAMAPiMF_00118_B EF_Tu_B, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR033720 EFTU_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
IPR004541 Transl_elong_EFTu/EF1A_bac/org
IPR004160 Transl_elong_EFTu/EF1A_C
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PF03143 GTP_EFTU_D3, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00485 EF-Tu, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5M5I8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEKYDRSK PHVNIGTIGH VDHGKTTLTA AITTVLARRL PSAVNTPKDY
60 70 80 90 100
ASIDAAPEER ERGITINTAH VEYETEKRHY AHIDAPGHAD YVKNMITGAA
110 120 130 140 150
QMDGAILVVA STDGPMPQTR EHILLSRQVG VKHLIVFMNK VDLVDDEELL
160 170 180 190 200
ELVEMEIRDL LSEYDFPGDD IPVIQGSALK ALEGDSKYED IIMDLMNTVD
210 220 230 240 250
EYIPEPERDT DKPLLLPVED VFSITGRGTV ASGRIDRGVV RVNDEVEIVG
260 270 280 290 300
LKEESQKAVV TGVEMFRKQL DEGIAGDNVG VLLRGIQRDE IERGQVLAAP
310 320 330 340 350
GSIKPHTKFK GEVYILTKEE GGRHTPFFNN YRPQFYFRTT DVTGSIELPA
360 370 380 390
GTEMVMPGDN VTIDVELIHP IAVEKGTTFS IREGGRTVGS GIVTEIEA
Length:398
Mass (Da):43,867
Last modified:February 1, 2005 - v1
Checksum:iBB1F9107DB470CB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000023 Genomic DNA Translation: AAV60197.1
RefSeqiWP_002949971.1, NC_006448.1

Genome annotation databases

EnsemblBacteriaiAAV60197; AAV60197; stu0487
GeneIDi31939312
KEGGistl:stu0487

Similar proteinsi

Entry informationi

Entry nameiEFTU_STRT2
AccessioniPrimary (citable) accession number: Q5M5I8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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