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Q5M4U2

- FTHS_STRT2

UniProt

Q5M4U2 - FTHS_STRT2

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, stu0791
Organism
Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTHE264199:GI6K-809-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:stu0791
OrganismiStreptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Taxonomic identifieri264199 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001170: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000199399Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264199.stu0791.

Structurei

3D structure databases

ProteinModelPortaliQ5M4U2.
SMRiQ5M4U2. Positions 4-554.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M4U2-1 [UniParc]FASTAAdd to Basket

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MKTDIEIAQS VELKPITEVV EKVGIGFDDL ELYGKYKAKL SFDKINEVKD    50
DKPGKLILVT AINPTPAGEG KSTISIGLAD ALNKIGKKTM IALREPSLGP 100
VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTANNAL SALLDNHIHQ 150
GNALGIDQRR IIWKRVVDLN DRALRHVTVG LGGPLNGIPR EDGFDITVAS 200
EIMAILCLAT DINDLKERLA NIVVAYRYDR TPVYVRDLEI EGALTLILKD 250
AIKPNLVQTI YGTPALVHGG PFANIAHGCN SVLATSTALR LADYTVTEAG 300
FGADLGAEKF LDIKTPNLPT TPDAVVIVAT LRALKMHGGV AKTDLSEENV 350
QAVRDGFSNL KRHVENIRKF GIPVVVAINE FVADTEAEIA ALKELCSEIK 400
VPVELASVWA NGADGGIDLA NTVVDVVENG NADYKRLYSD DDSLEEKITK 450
IVTEIYGGKS VVFEKKAKNQ LKQFAEFGWD KLPVCMAKTQ YSFSDNQFLL 500
GAPEGFDITI REFVPKTGAG FIVALTGDVM TMPGLPKAPA ALKMDVTEDG 550
TAVGLF 556
Length:556
Mass (Da):59,778
Last modified:February 1, 2005 - v1
Checksum:iEE071D3138357CCA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000023 Genomic DNA. Translation: AAV60470.1.
RefSeqiYP_139285.1. NC_006448.1.

Genome annotation databases

EnsemblBacteriaiAAV60470; AAV60470; stu0791.
GeneIDi3164606.
KEGGistl:stu0791.
PATRICi19803163. VBIStrThe97850_0787.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000023 Genomic DNA. Translation: AAV60470.1 .
RefSeqi YP_139285.1. NC_006448.1.

3D structure databases

ProteinModelPortali Q5M4U2.
SMRi Q5M4U2. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264199.stu0791.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV60470 ; AAV60470 ; stu0791 .
GeneIDi 3164606.
KEGGi stl:stu0791.
PATRICi 19803163. VBIStrThe97850_0787.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci STHE264199:GI6K-809-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-250 / LMG 18311.

Entry informationi

Entry nameiFTHS_STRT2
AccessioniPrimary (citable) accession number: Q5M4U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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