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Protein

tRNA pseudouridine synthase B

Gene

truB

Organism
Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(55) = tRNA pseudouridine(55).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei39NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Enzyme and pathway databases

BioCyciSTHE264199:G1G41-969-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase BUniRule annotation (EC:5.4.99.25UniRule annotation)
Alternative name(s):
tRNA pseudouridine(55) synthaseUniRule annotation
Short name:
Psi55 synthaseUniRule annotation
tRNA pseudouridylate synthaseUniRule annotation
tRNA-uridine isomeraseUniRule annotation
Gene namesi
Name:truBUniRule annotation
Ordered Locus Names:stu0995
OrganismiStreptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Taxonomic identifieri264199 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001170 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001219221 – 293tRNA pseudouridine synthase BAdd BLAST293

Interactioni

Protein-protein interaction databases

STRINGi264199.stu0995

Structurei

3D structure databases

ProteinModelPortaliQ5M4G2
SMRiQ5M4G2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0T Bacteria
COG0130 LUCA
HOGENOMiHOG000231225
KOiK03177
OMAiVDCSKGT

Family and domain databases

HAMAPiMF_01080 TruB_bact, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR002501 PsdUridine_synth_N
IPR014780 tRNA_psdUridine_synth_TruB
IPR032819 TruB_C
PANTHERiPTHR13767 PTHR13767, 1 hit
PfamiView protein in Pfam
PF16198 TruB_C_2, 1 hit
PF01509 TruB_N, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00431 TruB, 1 hit

Sequencei

Sequence statusi: Complete.

Q5M4G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISGIINLKK EAGMTSHDAV FKLRKILHEK KIGHGGTLDP DVTGVLPIAV
60 70 80 90 100
GKATRVIEYM TEAGKVYEGE ITIGFSTTTE DASGEVVQTT PITELDGATV
110 120 130 140 150
DQAMASFEGE ITQIPPMYSA VKINGKKLYE YARAGEEVER PQRQVKITEF
160 170 180 190 200
VRTSPIELEN GTARFTFRVA CSKGTYVRTL SVDLGVKLGF ASHMSALRRT
210 220 230 240 250
ASAGLTLDSS LSLSQISEMV EAGDQSFLLP IEFGVQDLPA VQVTEDDAKE
260 270 280 290
ISFGRFISIN SQEPLVAAFL GDKVLAIMEK RGQVYKPRKV LSQ
Length:293
Mass (Da):31,867
Last modified:February 1, 2005 - v1
Checksum:i259B8ABFD40C0C07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000023 Genomic DNA Translation: AAV60655.1
RefSeqiWP_004197018.1, NC_006448.1

Genome annotation databases

EnsemblBacteriaiAAV60655; AAV60655; stu0995
KEGGistl:stu0995

Similar proteinsi

Entry informationi

Entry nameiTRUB_STRT2
AccessioniPrimary (citable) accession number: Q5M4G2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: February 1, 2005
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health