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Q5M348

- TRPC_STRT2

UniProt

Q5M348 - TRPC_STRT2

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Protein

Indole-3-glycerol phosphate synthase

Gene

trpC

Organism
Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciSTHE264199:GI6K-1536-MONOMER.
UniPathwayiUPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Indole-3-glycerol phosphate synthaseUniRule annotation (EC:4.1.1.48UniRule annotation)
Short name:
IGPSUniRule annotation
Gene namesi
Name:trpCUniRule annotation
Ordered Locus Names:stu1590
OrganismiStreptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Taxonomic identifieri264199 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001170: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255Indole-3-glycerol phosphate synthasePRO_1000095901Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264199.stu1590.

Structurei

3D structure databases

ProteinModelPortaliQ5M348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpC family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0134.
HOGENOMiHOG000230462.
KOiK01609.
OMAiENGAAMI.
OrthoDBiEOG6WT8JX.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00134_B. IGPS_B.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M348 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKAFLPTIL EQKGKEVSQL VMEDLQPLRQ TYRLYDFLKS NQNKLQIISE
60 70 80 90 100
VKKASPSMGD INLDVDIVAQ AKTYEENGAA MISVLTDEVF FKGDISYLKE
110 120 130 140 150
ISTQVAIPTL AKDFIIDEKQ IVRSRNAGAT VILLIVAALP EARLKELYDF
160 170 180 190 200
ATSLGLEVLV ETHNLPELEV AHRIGAEIIG VNNRNLVTFE TDINTSLELS
210 220 230 240 250
THFKDKPVYI SESAIFTGQD AALVAPYFNG ILVGTALMTA DNVAKKVKEL

QIDKG
Length:255
Mass (Da):28,188
Last modified:February 1, 2005 - v1
Checksum:iFEBDB1A34FA0FA56
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000023 Genomic DNA. Translation: AAV61193.1.
RefSeqiWP_011226423.1. NC_006448.1.
YP_140008.1. NC_006448.1.

Genome annotation databases

EnsemblBacteriaiAAV61193; AAV61193; stu1590.
GeneIDi3164172.
KEGGistl:stu1590.
PATRICi19804729. VBIStrThe97850_1562.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000023 Genomic DNA. Translation: AAV61193.1 .
RefSeqi WP_011226423.1. NC_006448.1.
YP_140008.1. NC_006448.1.

3D structure databases

ProteinModelPortali Q5M348.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264199.stu1590.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV61193 ; AAV61193 ; stu1590 .
GeneIDi 3164172.
KEGGi stl:stu1590.
PATRICi 19804729. VBIStrThe97850_1562.

Phylogenomic databases

eggNOGi COG0134.
HOGENOMi HOG000230462.
KOi K01609.
OMAi ENGAAMI.
OrthoDBi EOG6WT8JX.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00043 .
BioCyci STHE264199:GI6K-1536-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00134_B. IGPS_B.
InterProi IPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00218. IGPS. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
PROSITEi PS00614. IGPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-250 / LMG 18311.

Entry informationi

Entry nameiTRPC_STRT2
AccessioniPrimary (citable) accession number: Q5M348
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 1, 2005
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3