Q5M348 (TRPC_STRT2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	stu1590

Organism

Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) [Complete proteome] [HAMAP]

Taxonomic identifier

264199 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus thermophilus

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP-Rule MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP-Rule MF_00134
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Indole-3-glycerol phosphate synthase HAMAP-Rule MF_00134		PRO_1000095901

Sequences

	Sequence		Length	Mass (Da)
	Q5M348 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: FEBDB1A34FA0FA56	FASTA	255	28,188
	10 20 30 40 50 60 MSKAFLPTIL EQKGKEVSQL VMEDLQPLRQ TYRLYDFLKS NQNKLQIISE VKKASPSMGD 70 80 90 100 110 120 INLDVDIVAQ AKTYEENGAA MISVLTDEVF FKGDISYLKE ISTQVAIPTL AKDFIIDEKQ 130 140 150 160 170 180 IVRSRNAGAT VILLIVAALP EARLKELYDF ATSLGLEVLV ETHNLPELEV AHRIGAEIIG 190 200 210 220 230 240 VNNRNLVTFE TDINTSLELS THFKDKPVYI SESAIFTGQD AALVAPYFNG ILVGTALMTA 250 DNVAKKVKEL QIDKG

References

[1]

"Complete sequence and comparative genome analysis of the dairy bacterium Streptococcus thermophilus." Bolotin A., Quinquis B., Renault P., Sorokin A., Ehrlich S.D., Kulakauskas S., Lapidus A., Goltsman E., Mazur M., Pusch G.D., Fonstein M., Overbeek R., Kyprides N., Purnelle B., Prozzi D., Ngui K., Masuy D., Hancy F. , Burteau S., Boutry M., Delcour J., Goffeau A., Hols P. Nat. Biotechnol. 22:1554-1558(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-250 / LMG 18311.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000023 Genomic DNA. Translation: AAV61193.1.
RefSeq	YP_140008.1. NC_006448.1.
3D structure databases
HSSP	HSSP built from PDB template 1I4N based on UniProtKB Q56319.
ProteinModelPortal	Q5M348.
ModBase	Search...
Protein-protein interaction databases
STRING	264199.stu1590.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAV61193; AAV61193; stu1590.
GeneID	3164172.
KEGG	stl:stu1590.
PATRIC	19804729. VBIStrThe97850_1562.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0134.
HOGENOM	HOG000230462.
KO	K01609.
OMA	GISYITD.
ProtClustDB	PRK00278.
Enzyme and pathway databases
UniPathway	UPA00035; UER00043.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00134_B. IGPS_B.
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_STRT2

Accession

Primary (citable) accession number: Q5M348

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 1, 2005
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program