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Q5M348 (TRPC_STRT2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Indole-3-glycerol phosphate synthase

Short name=IGPS
EC=4.1.1.48
Gene names
Name:trpC
Ordered Locus Names:stu1590
OrganismStreptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) [Complete proteome] [HAMAP]
Taxonomic identifier264199 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP-Rule MF_00134

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP-Rule MF_00134

Sequence similarities

Belongs to the TrpC family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionindole-3-glycerol-phosphate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 255255Indole-3-glycerol phosphate synthase HAMAP-Rule MF_00134
PRO_1000095901

Sequences

Sequence LengthMass (Da)Tools
Q5M348 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: FEBDB1A34FA0FA56

FASTA25528,188
        10         20         30         40         50         60 
MSKAFLPTIL EQKGKEVSQL VMEDLQPLRQ TYRLYDFLKS NQNKLQIISE VKKASPSMGD 

        70         80         90        100        110        120 
INLDVDIVAQ AKTYEENGAA MISVLTDEVF FKGDISYLKE ISTQVAIPTL AKDFIIDEKQ 

       130        140        150        160        170        180 
IVRSRNAGAT VILLIVAALP EARLKELYDF ATSLGLEVLV ETHNLPELEV AHRIGAEIIG 

       190        200        210        220        230        240 
VNNRNLVTFE TDINTSLELS THFKDKPVYI SESAIFTGQD AALVAPYFNG ILVGTALMTA 

       250 
DNVAKKVKEL QIDKG 

« Hide

References

[1]"Complete sequence and comparative genome analysis of the dairy bacterium Streptococcus thermophilus."
Bolotin A., Quinquis B., Renault P., Sorokin A., Ehrlich S.D., Kulakauskas S., Lapidus A., Goltsman E., Mazur M., Pusch G.D., Fonstein M., Overbeek R., Kyprides N., Purnelle B., Prozzi D., Ngui K., Masuy D., Hancy F. expand/collapse author list , Burteau S., Boutry M., Delcour J., Goffeau A., Hols P.
Nat. Biotechnol. 22:1554-1558(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-250 / LMG 18311.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000023 Genomic DNA. Translation: AAV61193.1.
RefSeqYP_140008.1. NC_006448.1.

3D structure databases

ProteinModelPortalQ5M348.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING264199.stu1590.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV61193; AAV61193; stu1590.
GeneID3164172.
KEGGstl:stu1590.
PATRIC19804729. VBIStrThe97850_1562.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0134.
HOGENOMHOG000230462.
KOK01609.
OMAGISYITD.
OrthoDBEOG6WT8JX.
ProtClustDBPRK00278.

Enzyme and pathway databases

BioCycSTHE264199:GI6K-1536-MONOMER.
UniPathwayUPA00035; UER00043.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00134_B. IGPS_B.
InterProIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
PROSITEPS00614. IGPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPC_STRT2
AccessionPrimary (citable) accession number: Q5M348
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 1, 2005
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways