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Q5M1R9

- DEF_STRT1

UniProt

Q5M1R9 - DEF_STRT1

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Protein
Peptide deformylase
Gene
def, str0151
Organism
Streptococcus thermophilus (strain CNRZ 1066)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi131 – 1311Iron By similarity
Metal bindingi174 – 1741Iron By similarity
Active sitei175 – 1751 By similarity
Metal bindingi178 – 1781Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciSTHE299768:GHWB-202-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase (EC:3.5.1.88)
Short name:
PDF
Alternative name(s):
Polypeptide deformylase
Gene namesi
Name:def
Ordered Locus Names:str0151
OrganismiStreptococcus thermophilus (strain CNRZ 1066)
Taxonomic identifieri299768 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001008: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204Peptide deformylaseUniRule annotation
PRO_0000301113Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi299768.str0151.

Structurei

3D structure databases

ProteinModelPortaliQ5M1R9.
SMRiQ5M1R9. Positions 3-204.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243507.
KOiK01462.
OMAiHIDKENP.
OrthoDBiEOG6PZXGQ.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5M1R9-1 [UniParc]FASTAAdd to Basket

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MDAQTKIIRA SHMIDMNDII REGNPTLRAV AEDVTLPLSD EDIILGEKMM    50
QFLRNSQDPV IAEKMGLRGG VGLAAPQLDI SKRIIAVLVP NPEDAKGNPP 100
KEAYSLQEIM YNPKVVAHSV QEAALGNGEG CLSVDRDVPG YVVRHARVTI 150
EYFNKEGEKK RIKLRGYDSI VVQHEIDHTN GIMFYDRINK DNPFTIKDGL 200
LIIE 204
Length:204
Mass (Da):22,777
Last modified:February 1, 2005 - v1
Checksum:i0E3CA97B1C7E7ADA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000024 Genomic DNA. Translation: AAV61765.1.
RefSeqiYP_140580.1. NC_006449.1.

Genome annotation databases

EnsemblBacteriaiAAV61765; AAV61765; str0151.
GeneIDi3166804.
KEGGistc:str0151.
PATRICi19793369. VBIStrThe135799_0161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000024 Genomic DNA. Translation: AAV61765.1 .
RefSeqi YP_140580.1. NC_006449.1.

3D structure databases

ProteinModelPortali Q5M1R9.
SMRi Q5M1R9. Positions 3-204.
ModBasei Search...

Protein-protein interaction databases

STRINGi 299768.str0151.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV61765 ; AAV61765 ; str0151 .
GeneIDi 3166804.
KEGGi stc:str0151.
PATRICi 19793369. VBIStrThe135799_0161.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243507.
KOi K01462.
OMAi HIDKENP.
OrthoDBi EOG6PZXGQ.

Enzyme and pathway databases

BioCyci STHE299768:GHWB-202-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CNRZ 1066.

Entry informationi

Entry nameiDEF_STRT1
AccessioniPrimary (citable) accession number: Q5M1R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi