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Protein

Urease subunit gamma

Gene

ureA

Organism
Streptococcus thermophilus (strain CNRZ 1066)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit alpha (ureC), Urease subunit gamma (ureA), Urease subunit beta (ureB)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSTHE299768:GHWB-330-MONOMER.
UniPathwayiUPA00258; UER00370.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit gammaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit gammaUniRule annotation
Gene namesi
Name:ureAUniRule annotation
Ordered Locus Names:str0281
OrganismiStreptococcus thermophilus (strain CNRZ 1066)
Taxonomic identifieri299768 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 100100Urease subunit gammaPRO_0000234218Add
BLAST

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5M1G8.
SMRiQ5M1G8. Positions 1-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the urease gamma subunit family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000075053.
KOiK01430.
OMAiELMSYGT.

Family and domain databases

CDDicd00390. Urease_gamma. 1 hit.
Gene3Di3.30.280.10. 1 hit.
HAMAPiMF_00739. Urease_gamma. 1 hit.
InterProiIPR012010. Urease_gamma.
IPR002026. Urease_gamma/gamma-beta_su.
[Graphical view]
PfamiPF00547. Urease_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001223. Urease_gamma. 1 hit.
ProDomiPD002319. Urease_gamma_reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54111. SSF54111. 1 hit.
TIGRFAMsiTIGR00193. urease_gam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5M1G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLTMREQEK MMISLAAMIA QRRKDKGIKL NHPEAVALIT DYVLEGAREG
60 70 80 90 100
KTVAQLMDEA RNLLTREDVM EGIAEMIPMI QVEATFTDST KLVTVHDPIQ
Length:100
Mass (Da):11,299
Last modified:February 1, 2005 - v1
Checksum:i8F7A87B354FABF7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000024 Genomic DNA. Translation: AAV61893.1.
RefSeqiWP_002886558.1. NC_006449.1.

Genome annotation databases

EnsemblBacteriaiAAV61893; AAV61893; str0281.
GeneIDi3164063.
KEGGistc:str0281.
PATRICi19793625. VBIStrThe135799_0289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000024 Genomic DNA. Translation: AAV61893.1.
RefSeqiWP_002886558.1. NC_006449.1.

3D structure databases

ProteinModelPortaliQ5M1G8.
SMRiQ5M1G8. Positions 1-99.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV61893; AAV61893; str0281.
GeneIDi3164063.
KEGGistc:str0281.
PATRICi19793625. VBIStrThe135799_0289.

Phylogenomic databases

HOGENOMiHOG000075053.
KOiK01430.
OMAiELMSYGT.

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.
BioCyciSTHE299768:GHWB-330-MONOMER.

Family and domain databases

CDDicd00390. Urease_gamma. 1 hit.
Gene3Di3.30.280.10. 1 hit.
HAMAPiMF_00739. Urease_gamma. 1 hit.
InterProiIPR012010. Urease_gamma.
IPR002026. Urease_gamma/gamma-beta_su.
[Graphical view]
PfamiPF00547. Urease_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001223. Urease_gamma. 1 hit.
ProDomiPD002319. Urease_gamma_reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54111. SSF54111. 1 hit.
TIGRFAMsiTIGR00193. urease_gam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiURE3_STRT1
AccessioniPrimary (citable) accession number: Q5M1G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: February 1, 2005
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.