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Protein

Probable manganese-dependent inorganic pyrophosphatase

Gene

ppaC

Organism
Streptococcus thermophilus (strain CNRZ 1066)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91Manganese 1UniRule annotation
Metal bindingi13 – 131Manganese 1UniRule annotation
Metal bindingi15 – 151Manganese 2UniRule annotation
Metal bindingi76 – 761Manganese 1UniRule annotation
Metal bindingi76 – 761Manganese 2UniRule annotation
Metal bindingi98 – 981Manganese 2UniRule annotation
Metal bindingi150 – 1501Manganese 2UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSTHE299768:GHWB-422-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese-dependent inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaCUniRule annotation
Ordered Locus Names:str0372
OrganismiStreptococcus thermophilus (strain CNRZ 1066)
Taxonomic identifieri299768 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Probable manganese-dependent inorganic pyrophosphatasePRO_1000012330Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5M194.
SMRiQ5M194. Positions 2-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000223999.
KOiK15986.
OMAiMLCAILS.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M194-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIFVFGHQ NPDSDAIGSS YGYAYLKRQL GVEAEAVALG TPNEETAFVL
60 70 80 90 100
DYFSVNAPRV VESAQSEGVN QVILTDHNEF QQSISDIKDV EVIEVVDHHR
110 120 130 140 150
VANFETANPL MMRLEPVGSA SSIVYRMFKE NNVEIPKDVA GLLLSGLISD
160 170 180 190 200
TLLLKSPTTH ASDPAVAEEL ARLAGVNLEE YGLAMLKAGT NLSSKSAEEL
210 220 230 240 250
IDIDAKTFEL NGNQVRVAQV NTVDISDVLS RQAEIEEAIN SSIKSNGYSD
260 270 280 290 300
FVLMITDILN SNSEILALGS NTDKIEKAFN FVLENNHAFL KGAVSRKKQV
310
VPQLTESFNV
Length:310
Mass (Da):33,810
Last modified:February 1, 2005 - v1
Checksum:i0FA3FB4FF8693F4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000024 Genomic DNA. Translation: AAV61975.1.
RefSeqiWP_011225519.1. NC_006449.1.

Genome annotation databases

EnsemblBacteriaiAAV61975; AAV61975; str0372.
GeneIDi3164072.
KEGGistc:str0372.
PATRICi19793813. VBIStrThe135799_0373.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000024 Genomic DNA. Translation: AAV61975.1.
RefSeqiWP_011225519.1. NC_006449.1.

3D structure databases

ProteinModelPortaliQ5M194.
SMRiQ5M194. Positions 2-309.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV61975; AAV61975; str0372.
GeneIDi3164072.
KEGGistc:str0372.
PATRICi19793813. VBIStrThe135799_0373.

Phylogenomic databases

HOGENOMiHOG000223999.
KOiK15986.
OMAiMLCAILS.

Enzyme and pathway databases

BioCyciSTHE299768:GHWB-422-MONOMER.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPAC_STRT1
AccessioniPrimary (citable) accession number: Q5M194
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 1, 2005
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.