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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Streptococcus thermophilus (strain CNRZ 1066)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTHE299768:G1G42-810-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:str0791
OrganismiStreptococcus thermophilus (strain CNRZ 1066)
Taxonomic identifieri299768 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001994001 – 556Formate--tetrahydrofolate ligaseAdd BLAST556

Proteomic databases

PRIDEiQ5M083

Structurei

3D structure databases

ProteinModelPortaliQ5M083
SMRiQ5M083
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5M083-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTDIEIAQS VELKPITEVV EKVGIGFDDL ELYGKYKAKL SFDKINEVKD
60 70 80 90 100
DKPGKLILVT AINPTPAGEG KSTMSIGLAD ALNKIGKKTM IALREPSLGP
110 120 130 140 150
VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTANNAL SALLDNHIHQ
160 170 180 190 200
GNALGIDQRR IIWKRVVDLN DRALRHVTVG LGGPLNGIPR EDGFDITVAS
210 220 230 240 250
EIMAILCLAT DINDLKERLA NIVVAYRYDR TPVYVRDLEI EGALTLILKD
260 270 280 290 300
AIKPNLVQTI YGTPALVHGG PFANIAHGCN SVLATSTALR LADYTVTEAG
310 320 330 340 350
FGADLGAEKF LDIKTPNLPT TPDAVVIVAT LRALKMHGGV AKTDLSEENV
360 370 380 390 400
QAVRDGFSNL KRHVENIRKF GIPVVVAINE FVADTEAEIA ALKELCSEIK
410 420 430 440 450
VPVELASVWA NGADGGIDLA NTVVDVVENG NADYKRLYSD DDSLEEKITK
460 470 480 490 500
IVTEIYGGKS VVFEKKAKNQ LKQFAEFGWD KLPVCMAKTQ YSFSDNQFLL
510 520 530 540 550
GAPEGFDITI REFVPKTGAG FIVALTGDVM TMPGLPKAPA ALKMDVTEDG

TAVGLF
Length:556
Mass (Da):59,796
Last modified:February 1, 2005 - v1
Checksum:iCD9C25A8370F25C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000024 Genomic DNA Translation: AAV62384.1
RefSeqiWP_011227107.1, NC_006449.1

Genome annotation databases

EnsemblBacteriaiAAV62384; AAV62384; str0791
GeneIDi31939046
KEGGistc:str0791

Similar proteinsi

Entry informationi

Entry nameiFTHS_STRT1
AccessioniPrimary (citable) accession number: Q5M083
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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