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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Streptococcus thermophilus (strain CNRZ 1066)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Enzyme and pathway databases

BioCyciSTHE299768:GHWB-1261-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:str1266Imported
OrganismiStreptococcus thermophilus (strain CNRZ 1066)Imported
Taxonomic identifieri299768 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001008 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi299768.str1266.

Structurei

3D structure databases

ProteinModelPortaliQ5LZ92.
SMRiQ5LZ92. Positions 2-372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiAMMLEYL.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5LZ92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERILMTNG NLKVTDNPII PFIEGDGVGR DIWKNAQAIF DKAVEVAYGG
60 70 80 90 100
QRRIEWQEFL AGKKAFDKTG EWLPQETLEA IRESLVAIKG PLETPVGGGI
110 120 130 140 150
RSLNVALRQE LDLYACVRPV RYFEGVASPL KEPEKTDITI FRENTEDIYA
160 170 180 190 200
GIEWEAGTVD VERVIAFFQT EMNVDKIRFP KSSSIGIKPI SIEGSKRLIR
210 220 230 240 250
SAIDYALKNN LKKVTLVHKG NIQKFTEGGF RKWGYEVAEE EYKEEMLAGR
260 270 280 290 300
LEVNDIIADN FLQQILLNPE KFDVVALTNL NGDYASDALA AQVGGIGISP
310 320 330 340 350
GANINYQTGH AIFEATHGTA PDIADQDRAN PCSILLSGCM LLEYIGWSEA
360 370 380 390
AELIISAIEK NFKSGIFTAD LAFGKRAYST SGFSNQILSI I
Length:391
Mass (Da):43,219
Last modified:February 1, 2005 - v1
Checksum:i8C4549316A051441
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000024 Genomic DNA. Translation: AAV62810.1.
RefSeqiWP_011226165.1. NC_006449.1.
YP_141625.1. NC_006449.1.

Genome annotation databases

EnsemblBacteriaiAAV62810; AAV62810; str1266.
GeneIDi3165469.
KEGGistc:str1266.
PATRICi19795595. VBIStrThe135799_1253.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000024 Genomic DNA. Translation: AAV62810.1.
RefSeqiWP_011226165.1. NC_006449.1.
YP_141625.1. NC_006449.1.

3D structure databases

ProteinModelPortaliQ5LZ92.
SMRiQ5LZ92. Positions 2-372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi299768.str1266.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV62810; AAV62810; str1266.
GeneIDi3165469.
KEGGistc:str1266.
PATRICi19795595. VBIStrThe135799_1253.

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiAMMLEYL.
OrthoDBiEOG6SNDTP.

Enzyme and pathway databases

BioCyciSTHE299768:GHWB-1261-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CNRZ 1066Imported.

Entry informationi

Entry nameiQ5LZ92_STRT1
AccessioniPrimary (citable) accession number: Q5LZ92
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 2005
Last sequence update: February 1, 2005
Last modified: April 29, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.