Q5LYY8 (GALT_STRT1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactose-1-phosphate uridylyltransferase
Short name=Gal-1-P uridylyltransferase
EC=2.7.7.12

Alternative name(s):
UDP-glucose--hexose-1-phosphate uridylyltransferase

Gene names

Name:	galT
Ordered Locus Names:	str1401

Organism

Streptococcus thermophilus (strain CNRZ 1066) [Complete proteome] [HAMAP]

Taxonomic identifier

299768 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose. HAMAP MF_00571
Pathway	Carbohydrate metabolism; galactose metabolism. HAMAP MF_00571
Subcellular location	Cytoplasm Potential HAMAP MF_00571.
Sequence similarities	Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
Sequence caution	The sequence AAV62938.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Cellular component	Cytoplasm
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UDP-glucose:hexose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Galactose-1-phosphate uridylyltransferase HAMAP MF_00571		PRO_0000169920

Sequences

	Sequence		Length	Mass (Da)
	Q5LYY8 [UniParc]. Last modified August 30, 2005. Version 2. Checksum: C33887C3F2BA6BBC	FASTA	493	55,472
	10 20 30 40 50 60 MAENLVNTFV TQVIENSDYE ELDRIYLTNK VFTLVGEGVA DVETDSSELI DLKDQLLQAG 70 80 90 100 110 120 VKAGSVGELN EEQDIIGAQL MDLITPRPSV VNRNFWDTYK SNPEQAIADF YAQSKRNDYV 130 140 150 160 170 180 KVKAIAQNIA YKAPTKYGDL EITINLSKPE KDPKAIAAAK NAVASDYPKC QLCMENEGYL 190 200 210 220 230 240 GRINHPARSN HRVVRFQMED KEWGFQYSPY AYFNEHSIFF YGKHEPMHIS PLTFGRLLTI 250 260 270 280 290 300 VEAFPGYFAG SNADLPIVGG SILTHEHYQG GRHTFPMEVA GIKEKVSFDG YSDVEAGIVN 310 320 330 340 350 360 WPMSVLRLRS EDKERLIALA TKILNCWRGY SDEKAGVLAE SDGQPHHTIT PIARRKDGKF 370 380 390 400 410 420 ELDLVLRDNQ TSEEYPDGIY HPHKDVQHIK KENIGLIEVM GLAILPPRLK TELKDVEDYL 430 440 450 460 470 480 LGQGNQVAPI HQEWADELKA QNPNITAEEV TEVVRQSVAD IFARVLEDAG VYKTNSEGLD 490 QFKAFVDFVN LAD

References

[1]

"Complete sequence and comparative genome analysis of the dairy bacterium Streptococcus thermophilus." Bolotin A., Quinquis B., Renault P., Sorokin A., Ehrlich S.D., Kulakauskas S., Lapidus A., Goltsman E., Mazur M., Pusch G.D., Fonstein M., Overbeek R., Kyprides N., Purnelle B., Prozzi D., Ngui K., Masuy D., Hancy F. , Burteau S., Boutry M., Delcour J., Goffeau A., Hols P. Nat. Biotechnol. 22:1554-1558(2004) [PubMed: 15543133] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CNRZ 1066.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000024 Genomic DNA. Translation: AAV62938.1. Different initiation.
RefSeq	YP_141753.1. NC_006449.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5LYY8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000062420; EBSTRP00000057987; EBSTRG00000062410.
GeneID	3167466.
GenomeReviews	Gene locus str1401 in contig CP000024_GR.
KEGG	stc:str1401.
PATRIC	19795873. VBIStrThe135799_1392.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4468.
GeneTree	EBGT00050000027103.
HOGENOM	HBG337915.
OMA	HYFIGSN.
ProtClustDB	PRK05270.
Enzyme and pathway databases
BioCyc	STHE299768:STR1401-MONOMER.
Family and domain databases
HAMAP	MF_00571. GalP_UDP_trans. [Tree]
InterPro	IPR000766. GalP_uridyl_Trfase_II. IPR023425. GalP_uridyl_Trfase_II_CS. IPR005850. GalP_Utransf_C. IPR005849. GalP_Utransf_N. [Graphical view]
KO	K00965.
Pfam	PF02744. GalP_UDP_tr_C. 1 hit. PF01087. GalP_UDP_transf. 1 hit. [Graphical view]
PIRSF	PIRSF006005. GalT_BS. 1 hit.
TIGRFAMs	TIGR01239. GalT_2. 1 hit.
PROSITE	PS01163. GAL_P_UDP_TRANSF_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GALT_STRT1

Accession

Primary (citable) accession number: Q5LYY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	August 30, 2005
Last modified:	January 25, 2012
This is version 41 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program