Q5LYV4 (PPNK_STRT1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	str1457

Organism

Streptococcus thermophilus (strain CNRZ 1066) [Complete proteome] [HAMAP]

Taxonomic identifier

299768 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus thermophilus

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP-Rule MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP-Rule MF_00361
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	NAD metabolic process Inferred from electronic annotation. Source: InterPro NADP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP-Rule MF_00361		PRO_0000229697

Sequences

	Sequence		Length	Mass (Da)
	Q5LYV4 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 6D23D4684D125FE6	FASTA	279	31,167
	10 20 30 40 50 60 MMTQMKTSSD EMKVAIIANG KPQSRRVASK LFNAFRDDPD FYLTKKNPDV LISIGGDGML 70 80 90 100 110 120 LSAFHMYEKE LARVRFVGIH TGHLGFYTDY LDSEVDQLIE TLRKDSGAKI SYPLLNVKLT 130 140 150 160 170 180 LADGRSFTSI ALNEAAIKRN EKTMAADVCL NDVLFESFRG DGLSVSTPTG STAYNKSLGG 190 200 210 220 230 240 AVLHPTIEAL QLTEIASLNN RVYRTLGSPL IVPKHEKITV YPTRMGSYTL SVDNKTYINR 250 260 270 NVKKVEFSID QRKISFVASA SHTSFWERVR ESFIGDMEE

References

[1]

"Complete sequence and comparative genome analysis of the dairy bacterium Streptococcus thermophilus." Bolotin A., Quinquis B., Renault P., Sorokin A., Ehrlich S.D., Kulakauskas S., Lapidus A., Goltsman E., Mazur M., Pusch G.D., Fonstein M., Overbeek R., Kyprides N., Purnelle B., Prozzi D., Ngui K., Masuy D., Hancy F. , Burteau S., Boutry M., Delcour J., Goffeau A., Hols P. Nat. Biotechnol. 22:1554-1558(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CNRZ 1066.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000024 Genomic DNA. Translation: AAV62993.1.
RefSeq	YP_141808.1. NC_006449.1.
3D structure databases
ProteinModelPortal	Q5LYV4.
ModBase	Search...
Protein-protein interaction databases
STRING	299768.str1457.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAV62993; AAV62993; str1457.
GeneID	3166415.
KEGG	stc:str1457.
PATRIC	19795989. VBIStrThe135799_1448.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0061.
HOGENOM	HOG000275803.
KO	K00858.
OMA	RTAHAIL.
ProtClustDB	PRK04885.
Enzyme and pathway databases
BioCyc	STHE299768:GHWB-1446-MONOMER.
Family and domain databases
Gene3D	2.60.200.30. 1 hit. 3.40.50.10330. 1 hit.
HAMAP	MF_00361. NAD_kinase.
InterPro	IPR017438. ATP-NAD_kinase_dom_1. IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. PolyP/ATP_NADK_prd. [Graphical view]
PANTHER	PTHR20275. PTHR20275. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_STRT1

Accession

Primary (citable) accession number: Q5LYV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	February 1, 2005
Last modified:	May 29, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program