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Q5LYV4

- NADK_STRT1

UniProt

Q5LYV4 - NADK_STRT1

Protein

NAD kinase

Gene

nadK

Organism
Streptococcus thermophilus (strain CNRZ 1066)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei57 – 571Proton acceptorUniRule annotation
    Binding sitei159 – 1591NADUniRule annotation
    Binding sitei161 – 1611NADUniRule annotation
    Binding sitei196 – 1961NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi57 – 582NADUniRule annotation
    Nucleotide bindingi133 – 1342NADUniRule annotation
    Nucleotide bindingi172 – 1776NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSTHE299768:GHWB-1446-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:str1457
    OrganismiStreptococcus thermophilus (strain CNRZ 1066)
    Taxonomic identifieri299768 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001008: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279NAD kinasePRO_0000229697Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi299768.str1457.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5LYV4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000275803.
    KOiK00858.
    OMAiWRADELE.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5LYV4-1 [UniParc]FASTAAdd to Basket

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    MMTQMKTSSD EMKVAIIANG KPQSRRVASK LFNAFRDDPD FYLTKKNPDV    50
    LISIGGDGML LSAFHMYEKE LARVRFVGIH TGHLGFYTDY LDSEVDQLIE 100
    TLRKDSGAKI SYPLLNVKLT LADGRSFTSI ALNEAAIKRN EKTMAADVCL 150
    NDVLFESFRG DGLSVSTPTG STAYNKSLGG AVLHPTIEAL QLTEIASLNN 200
    RVYRTLGSPL IVPKHEKITV YPTRMGSYTL SVDNKTYINR NVKKVEFSID 250
    QRKISFVASA SHTSFWERVR ESFIGDMEE 279
    Length:279
    Mass (Da):31,167
    Last modified:February 1, 2005 - v1
    Checksum:i6D23D4684D125FE6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000024 Genomic DNA. Translation: AAV62993.1.
    RefSeqiWP_011226317.1. NC_006449.1.
    YP_141808.1. NC_006449.1.

    Genome annotation databases

    EnsemblBacteriaiAAV62993; AAV62993; str1457.
    GeneIDi3166415.
    KEGGistc:str1457.
    PATRICi19795989. VBIStrThe135799_1448.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000024 Genomic DNA. Translation: AAV62993.1 .
    RefSeqi WP_011226317.1. NC_006449.1.
    YP_141808.1. NC_006449.1.

    3D structure databases

    ProteinModelPortali Q5LYV4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 299768.str1457.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV62993 ; AAV62993 ; str1457 .
    GeneIDi 3166415.
    KEGGi stc:str1457.
    PATRICi 19795989. VBIStrThe135799_1448.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000275803.
    KOi K00858.
    OMAi WRADELE.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci STHE299768:GHWB-1446-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CNRZ 1066.

    Entry informationi

    Entry nameiNADK_STRT1
    AccessioniPrimary (citable) accession number: Q5LYV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3