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Q5LYV4

- NADK_STRT1

UniProt

Q5LYV4 - NADK_STRT1

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Protein
NAD kinase
Gene
nadK, str1457
Organism
Streptococcus thermophilus (strain CNRZ 1066)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei57 – 571Proton acceptor By similarity
Binding sitei159 – 1591NAD By similarity
Binding sitei161 – 1611NAD By similarity
Binding sitei196 – 1961NAD; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi57 – 582NAD By similarity
Nucleotide bindingi133 – 1342NAD By similarity
Nucleotide bindingi172 – 1776NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTHE299768:GHWB-1446-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:str1457
OrganismiStreptococcus thermophilus (strain CNRZ 1066)
Taxonomic identifieri299768 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001008: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279NAD kinaseUniRule annotation
PRO_0000229697Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi299768.str1457.

Structurei

3D structure databases

ProteinModelPortaliQ5LYV4.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000275803.
KOiK00858.
OMAiWRADELE.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5LYV4-1 [UniParc]FASTAAdd to Basket

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MMTQMKTSSD EMKVAIIANG KPQSRRVASK LFNAFRDDPD FYLTKKNPDV    50
LISIGGDGML LSAFHMYEKE LARVRFVGIH TGHLGFYTDY LDSEVDQLIE 100
TLRKDSGAKI SYPLLNVKLT LADGRSFTSI ALNEAAIKRN EKTMAADVCL 150
NDVLFESFRG DGLSVSTPTG STAYNKSLGG AVLHPTIEAL QLTEIASLNN 200
RVYRTLGSPL IVPKHEKITV YPTRMGSYTL SVDNKTYINR NVKKVEFSID 250
QRKISFVASA SHTSFWERVR ESFIGDMEE 279
Length:279
Mass (Da):31,167
Last modified:February 1, 2005 - v1
Checksum:i6D23D4684D125FE6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000024 Genomic DNA. Translation: AAV62993.1.
RefSeqiWP_011226317.1. NC_006449.1.
YP_141808.1. NC_006449.1.

Genome annotation databases

EnsemblBacteriaiAAV62993; AAV62993; str1457.
GeneIDi3166415.
KEGGistc:str1457.
PATRICi19795989. VBIStrThe135799_1448.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000024 Genomic DNA. Translation: AAV62993.1 .
RefSeqi WP_011226317.1. NC_006449.1.
YP_141808.1. NC_006449.1.

3D structure databases

ProteinModelPortali Q5LYV4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 299768.str1457.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV62993 ; AAV62993 ; str1457 .
GeneIDi 3166415.
KEGGi stc:str1457.
PATRICi 19795989. VBIStrThe135799_1448.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000275803.
KOi K00858.
OMAi WRADELE.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci STHE299768:GHWB-1446-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CNRZ 1066.

Entry informationi

Entry nameiNADK_STRT1
AccessioniPrimary (citable) accession number: Q5LYV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 1, 2005
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi