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Q5LWL4

- IF2_RUEPO

UniProt

Q5LWL4 - IF2_RUEPO

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi341 – 3488GTPUniRule annotation
    Nucleotide bindingi388 – 3925GTPUniRule annotation
    Nucleotide bindingi442 – 4454GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:SPO0061
    OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
    Taxonomic identifieri246200 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
    ProteomesiUP000001023: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 835835Translation initiation factor IF-2PRO_0000228244Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi246200.SPO0061.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5LWL4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini332 – 500169tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni341 – 3488G1By similarity
    Regioni366 – 3705G2By similarity
    Regioni388 – 3914G3By similarity
    Regioni442 – 4454G4By similarity
    Regioni478 – 4803G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076907.
    KOiK02519.
    OMAiHKITDVI.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5LWL4-1 [UniParc]FASTAAdd to Basket

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    MSDTDGKKTL GLRGSRPGNV KQSFSHGRTK NVVVETKRKR VVVPKPGAGK    50
    PSAGGSSPAG DPSRRPAGIS DAEMERRLNA LKAAKARESE EAAQREAEEK 100
    ARAEERERRR AEQEAKEREQ REAEQRAREK AEEEERQRRE AEEEAKRAAV 150
    RAAAEQEAPK AERSAERAPA AARPEGGDNA RRTTDRDRER EQRQTRGKGR 200
    QDGRRSGKLT LSQVTDGEGG RQKSLAAMKR KQERARQKAM GGAAEREKVI 250
    REVQLPEAIV VSELANRMAE RVADVVKELM KMGMMVTQNQ TIDADTAELI 300
    IEEFGHKVVR VSDSDVEDVI SDIEDAEEDL KPRPPVITIM GHVDHGKTSL 350
    LDAIRDAKVV AGEAGGITQH IGAYQVKTDG GATLSFLDTP GHAAFTSMRS 400
    RGAQVTDIVV LVVAADDAVM PQTVEAINHA KAAGVPMIVA INKIDKPEAN 450
    PTKVRTDLLQ HEVVVEAMSG EVQDVEVSAK TGEGLDELLE AIALQAEILE 500
    LKANPDRPAQ GAVIEAQLDV GRGPVATVLI QKGTLRQGDI FVVGEQYGKV 550
    RALINDKGER VSEAGPSVPV EVLGLNGTPE AGDVLNVTST EAQAREIAEY 600
    RAQVAKDKRA AAGAATTLEQ LMAKAKADEN VAELPILVKA DVQGSAEAIV 650
    QAMEKIGNDE VRVRVLHSGV GAITETDVGL AEASGAPIMG FNVRANASAR 700
    NTANQKGVEI RYYSVIYDLV DDVKAAASGL LSAEIRENFI GYANIKEVFK 750
    VSNVGKVAGC LVTEGVARRS AGVRLLRDNV VIHEGTLKTL KRFKDEVAEV 800
    QSGQECGMAF ENYDDIRPGD VIEIFEREEV TRTLT 835
    Length:835
    Mass (Da):90,200
    Last modified:February 1, 2005 - v1
    Checksum:i543CC094F33DD84A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000031 Genomic DNA. Translation: AAV93392.1.
    RefSeqiYP_165335.1. NC_003911.12.

    Genome annotation databases

    EnsemblBacteriaiAAV93392; AAV93392; SPO0061.
    GeneIDi3193823.
    KEGGisil:SPO0061.
    PATRICi23373359. VBIRuePom114501_0065.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000031 Genomic DNA. Translation: AAV93392.1 .
    RefSeqi YP_165335.1. NC_003911.12.

    3D structure databases

    ProteinModelPortali Q5LWL4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246200.SPO0061.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV93392 ; AAV93392 ; SPO0061 .
    GeneIDi 3193823.
    KEGGi sil:SPO0061.
    PATRICi 23373359. VBIRuePom114501_0065.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076907.
    KOi K02519.
    OMAi HKITDVI.
    OrthoDBi EOG67HJSV.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700808 / DSM 15171 / DSS-3.

    Entry informationi

    Entry nameiIF2_RUEPO
    AccessioniPrimary (citable) accession number: Q5LWL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3