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Q5LWL4

- IF2_RUEPO

UniProt

Q5LWL4 - IF2_RUEPO

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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi341 – 3488GTPUniRule annotation
Nucleotide bindingi388 – 3925GTPUniRule annotation
Nucleotide bindingi442 – 4454GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:SPO0061
OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Taxonomic identifieri246200 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
ProteomesiUP000001023: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 835835Translation initiation factor IF-2PRO_0000228244Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246200.SPO0061.

Structurei

3D structure databases

ProteinModelPortaliQ5LWL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini332 – 500169tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni341 – 3488G1By similarity
Regioni366 – 3705G2By similarity
Regioni388 – 3914G3By similarity
Regioni442 – 4454G4By similarity
Regioni478 – 4803G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076907.
KOiK02519.
OMAiHKITDVI.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5LWL4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDTDGKKTL GLRGSRPGNV KQSFSHGRTK NVVVETKRKR VVVPKPGAGK
60 70 80 90 100
PSAGGSSPAG DPSRRPAGIS DAEMERRLNA LKAAKARESE EAAQREAEEK
110 120 130 140 150
ARAEERERRR AEQEAKEREQ REAEQRAREK AEEEERQRRE AEEEAKRAAV
160 170 180 190 200
RAAAEQEAPK AERSAERAPA AARPEGGDNA RRTTDRDRER EQRQTRGKGR
210 220 230 240 250
QDGRRSGKLT LSQVTDGEGG RQKSLAAMKR KQERARQKAM GGAAEREKVI
260 270 280 290 300
REVQLPEAIV VSELANRMAE RVADVVKELM KMGMMVTQNQ TIDADTAELI
310 320 330 340 350
IEEFGHKVVR VSDSDVEDVI SDIEDAEEDL KPRPPVITIM GHVDHGKTSL
360 370 380 390 400
LDAIRDAKVV AGEAGGITQH IGAYQVKTDG GATLSFLDTP GHAAFTSMRS
410 420 430 440 450
RGAQVTDIVV LVVAADDAVM PQTVEAINHA KAAGVPMIVA INKIDKPEAN
460 470 480 490 500
PTKVRTDLLQ HEVVVEAMSG EVQDVEVSAK TGEGLDELLE AIALQAEILE
510 520 530 540 550
LKANPDRPAQ GAVIEAQLDV GRGPVATVLI QKGTLRQGDI FVVGEQYGKV
560 570 580 590 600
RALINDKGER VSEAGPSVPV EVLGLNGTPE AGDVLNVTST EAQAREIAEY
610 620 630 640 650
RAQVAKDKRA AAGAATTLEQ LMAKAKADEN VAELPILVKA DVQGSAEAIV
660 670 680 690 700
QAMEKIGNDE VRVRVLHSGV GAITETDVGL AEASGAPIMG FNVRANASAR
710 720 730 740 750
NTANQKGVEI RYYSVIYDLV DDVKAAASGL LSAEIRENFI GYANIKEVFK
760 770 780 790 800
VSNVGKVAGC LVTEGVARRS AGVRLLRDNV VIHEGTLKTL KRFKDEVAEV
810 820 830
QSGQECGMAF ENYDDIRPGD VIEIFEREEV TRTLT
Length:835
Mass (Da):90,200
Last modified:February 1, 2005 - v1
Checksum:i543CC094F33DD84A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000031 Genomic DNA. Translation: AAV93392.1.
RefSeqiWP_011045834.1. NC_003911.12.
YP_165335.1. NC_003911.12.

Genome annotation databases

EnsemblBacteriaiAAV93392; AAV93392; SPO0061.
GeneIDi3193823.
KEGGisil:SPO0061.
PATRICi23373359. VBIRuePom114501_0065.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000031 Genomic DNA. Translation: AAV93392.1 .
RefSeqi WP_011045834.1. NC_003911.12.
YP_165335.1. NC_003911.12.

3D structure databases

ProteinModelPortali Q5LWL4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246200.SPO0061.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV93392 ; AAV93392 ; SPO0061 .
GeneIDi 3193823.
KEGGi sil:SPO0061.
PATRICi 23373359. VBIRuePom114501_0065.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076907.
KOi K02519.
OMAi HKITDVI.
OrthoDBi EOG67HJSV.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700808 / DSM 15171 / DSS-3.

Entry informationi

Entry nameiIF2_RUEPO
AccessioniPrimary (citable) accession number: Q5LWL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: February 1, 2005
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3