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Protein

Argininosuccinate synthase

Gene

argG

Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei90CitrullineUniRule annotation1
Binding sitei95CitrullineUniRule annotation1
Binding sitei120ATP; via amide nitrogenUniRule annotation1
Binding sitei122AspartateUniRule annotation1
Binding sitei126AspartateUniRule annotation1
Binding sitei126CitrullineUniRule annotation1
Binding sitei127AspartateUniRule annotation1
Binding sitei130CitrullineUniRule annotation1
Binding sitei181CitrullineUniRule annotation1
Binding sitei190CitrullineUniRule annotation1
Binding sitei266CitrullineUniRule annotation1
Binding sitei278CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRPOM246200:G1G48-18-MONOMER
UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:SPO0018
OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Taxonomic identifieri246200 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
Proteomesi
  • UP000001023 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001486341 – 409Argininosuccinate synthaseAdd BLAST409

Proteomic databases

PRIDEiQ5LWG3

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi246200.SPO0018

Structurei

3D structure databases

ProteinModelPortaliQ5LWG3
SMRiQ5LWG3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230093
KOiK01940
OMAiGVGRIDM
OrthoDBiPOG091H01U0

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5LWG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPKKVVLA YSGGLDTSII LKWLQTEYGC EVVTFTADLG QGEELEPARK
60 70 80 90 100
KAELLGIKPE NIHIEDVREE FVRDFVFPMF RANAVYEGLY LLGTSIARPL
110 120 130 140 150
ISKRLVEIAA EHGADAVAHG ATGKGNDQVR FELSAYALNP EIRVIAPWRL
160 170 180 190 200
WDLTSRTRLL EFAEAHQIPI SKDKRGEAPF SVDANLLHTS SEGKVLEDPG
210 220 230 240 250
VEAPDYVAQR IVAVEDAPDT PEFIEVTFEK GDAVAINGEA MSPATILTRL
260 270 280 290 300
NELGGKHGIG LLDFVENRFV GMKSRGVYET PGGTILLEAH RGIEQITLDS
310 320 330 340 350
GAGHLKDSIM PRYAELIYNG FWFSPEREML QALIDKSQEH VTGTVRLKLY
360 370 380 390 400
KGSARTVARW SDHSLYSEAH VTFEEDAGAY DQQDAKGFIQ LNALRLKLLA

TRNRRVAGK
Length:409
Mass (Da):45,288
Last modified:February 1, 2005 - v1
Checksum:iC86CDB6E926AE5DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000031 Genomic DNA Translation: AAV93349.1
RefSeqiWP_011045790.1, NC_003911.12

Genome annotation databases

EnsemblBacteriaiAAV93349; AAV93349; SPO0018
KEGGisil:SPO0018

Similar proteinsi

Entry informationi

Entry nameiASSY_RUEPO
AccessioniPrimary (citable) accession number: Q5LWG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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