ID   Q5LVX3_RUEPO            Unreviewed;       571 AA.
AC   Q5LVX3;
DT   01-FEB-2005, integrated into UniProtKB/TrEMBL.
DT   01-FEB-2005, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:AAV93887.1};
GN   OrderedLocusNames=SPO0572 {ECO:0000313|EMBL:AAV93887.1};
OS   Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter
OS   pomeroyi).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Ruegeria.
OX   NCBI_TaxID=246200 {ECO:0000313|EMBL:AAV93887.1, ECO:0000313|Proteomes:UP000001023};
RN   [1] {ECO:0000313|EMBL:AAV93887.1, ECO:0000313|Proteomes:UP000001023}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700808 / DSM 15171 / DSS-3
RC   {ECO:0000313|Proteomes:UP000001023};
RX   PubMed=15602564; DOI=10.1038/nature03170;
RA   Moran M.A., Buchan A., Gonzalez J.M., Heidelberg J.F., Whitman W.B.,
RA   Kiene R.P., Henriksen J.R., King G.M., Belas R., Fuqua C., Brinkac L.,
RA   Lewis M., Johri S., Weaver B., Pai G., Eisen J.A., Rahe E., Sheldon W.M.,
RA   Ye W., Miller T.R., Carlton J., Rasko D.A., Paulsen I.T., Ren Q.,
RA   Daugherty S.C., Deboy R.T., Dodson R.J., Durkin A.S., Madupu R.,
RA   Nelson W.C., Sullivan S.A., Rosovitz M.J., Haft D.H., Selengut J., Ward N.;
RT   "Genome sequence of Silicibacter pomeroyi reveals adaptations to the marine
RT   environment.";
RL   Nature 432:910-913(2004).
RN   [2] {ECO:0000313|EMBL:AAV93887.1, ECO:0000313|Proteomes:UP000001023}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 700808 / DSM 15171 / DSS-3
RC   {ECO:0000313|Proteomes:UP000001023};
RX   PubMed=25780504; DOI=10.1186/1944-3277-9-11;
RA   Rivers A.R., Smith C.B., Moran M.A.;
RT   "An updated genome annotation for the model marine bacterium Ruegeria
RT   pomeroyi DSS-3.";
RL   Stand. Genomic Sci. 9:11-11(2014).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000256|ARBA:ARBA00005381}.
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DR   EMBL; CP000031; AAV93887.1; -; Genomic_DNA.
DR   RefSeq; WP_011046328.1; NC_003911.12.
DR   AlphaFoldDB; Q5LVX3; -.
DR   STRING; 246200.SPO0572; -.
DR   PaxDb; 246200-SPO0572; -.
DR   KEGG; sil:SPO0572; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG2770; Bacteria.
DR   HOGENOM; CLU_477243_0_0_5; -.
DR   OrthoDB; 9789782at2; -.
DR   Proteomes; UP000001023; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF158472; HAMP domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001023};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        292..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          312..365
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          396..521
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   571 AA;  61618 MW;  28A23A03153DB042 CRC64;
     MRFPLRLKFF VFAVLLAMGP LALVGQNLTQ LTRDELKSAA NEDLTTVAAE LRATFDNTFQ
     GRWLTPLTVI RNGVDSADLG VPQKISLLTL GLQELSQVVA LQLSIEGSDL PIIVTNEGFA
     TRLSEAGLNP VEALATSSEL IKAIAGTGQY GRPVITRLEE TGDWLATLAL PLETRIAGRQ
     VTMAARIDLG LLGETVRRHP FAQRGEITVV DQAGRRVLTG TPELLDKRRI VASTLPLIVA
     GARADALEPY VRPDGTAMLG AYAFPDWFPW AVITELSEDN AYAVVNAITR QILTVGLVGF
     AVAAAAALLF ARQLTRPILM IGQVAQRVGE GDFSARVEDV RARDEIGDLA ARFNRMIAHL
     GERVELMKFV SHSTMSAIQS AERTGMARGG QRRRVSVIFT DIRGYTEFSE RVPPETVIEV
     LNSYFDAQTD IVEHYKGDVD KFVGDALVAV FEGDGMEARA VACAVGITEA MARLLEENPE
     HGLHVGIGVA SGEVVMGAMG ARDRMDFTVL GSTVNLSARL CSKAAADQVL IDRETRDAAV
     LEDIVYEPLE PIALKGYAAP VPAFAALRKA G
//