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Q5LVV1

- HISX1_RUEPO

UniProt

Q5LVV1 - HISX1_RUEPO

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Protein

Histidinol dehydrogenase 1

Gene

hisD1

Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei119 – 1191NADUniRule annotation
Binding sitei181 – 1811NADUniRule annotation
Binding sitei204 – 2041NADUniRule annotation
Binding sitei227 – 2271SubstrateUniRule annotation
Metal bindingi249 – 2491ZincUniRule annotation
Binding sitei249 – 2491SubstrateUniRule annotation
Metal bindingi252 – 2521ZincUniRule annotation
Binding sitei252 – 2521SubstrateUniRule annotation
Active sitei319 – 3191Proton acceptorUniRule annotation
Active sitei320 – 3201Proton acceptorUniRule annotation
Binding sitei320 – 3201SubstrateUniRule annotation
Metal bindingi353 – 3531ZincUniRule annotation
Binding sitei353 – 3531SubstrateUniRule annotation
Binding sitei407 – 4071SubstrateUniRule annotation
Metal bindingi412 – 4121ZincUniRule annotation
Binding sitei412 – 4121SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 1UniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDH 1UniRule annotation
Gene namesi
Name:hisD1UniRule annotation
Ordered Locus Names:SPO0594
OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Taxonomic identifieri246200 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
ProteomesiUP000001023: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Histidinol dehydrogenase 1PRO_0000135846Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246200.SPO0594.

Structurei

3D structure databases

ProteinModelPortaliQ5LVV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK15509.
OMAiISRLEGM.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5LVV1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIEYLKKAS LTSKSDASDV QETVRAILAD IEAGGDQVAL DYAAKFDRYE
60 70 80 90 100
GSIILSPEEI EAACAKVPEK LKADIRFAHD NVRRFAETQK ATLTDVELEV
110 120 130 140 150
VPGVITGQKA IPVDAAGCYV PGGRYSHIAS AIMTVTTAKV AGCKHIMACS
160 170 180 190 200
PPRPGVGVAP AIVYAAHICG ADTIMAIGGV QGVASMAFGL FGLPKAKILV
210 220 230 240 250
GPGNQFVAEA KRMLFGRVGI DMIAGPTDSL ILADRTADPH IVTTDLVSQA
260 270 280 290 300
EHGYNSPVWL VTDDRALAEK VIEMIPSYIA DLPEVNRDNA AAAWRDYAEV
310 320 330 340 350
ILCADREEMA ATSDRYAPEH LTVMAEDLDW WLDRLSCYGS LFLGEESTVS
360 370 380 390 400
YGDKAAGTNH VLPTSGAASY TGGLSVHKYM KIVTWQRGTR EGYKPVAEAT
410 420 430
ARIARLEGME GHARAADVRL AKYFPDETFD LTANG
Length:435
Mass (Da):46,644
Last modified:February 1, 2005 - v1
Checksum:i093DF7F337198357
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000031 Genomic DNA. Translation: AAV93909.1.
RefSeqiYP_165854.1. NC_003911.12.

Genome annotation databases

EnsemblBacteriaiAAV93909; AAV93909; SPO0594.
GeneIDi3193878.
KEGGisil:SPO0594.
PATRICi23374455. VBIRuePom114501_0602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000031 Genomic DNA. Translation: AAV93909.1 .
RefSeqi YP_165854.1. NC_003911.12.

3D structure databases

ProteinModelPortali Q5LVV1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246200.SPO0594.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV93909 ; AAV93909 ; SPO0594 .
GeneIDi 3193878.
KEGGi sil:SPO0594.
PATRICi 23374455. VBIRuePom114501_0602.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K15509.
OMAi ISRLEGM.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700808 / DSM 15171 / DSS-3.

Entry informationi

Entry nameiHISX1_RUEPO
AccessioniPrimary (citable) accession number: Q5LVV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: February 1, 2005
Last modified: November 26, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3