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Q5LVN3 (SYH_RUEPO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidine--tRNA ligase

EC=6.1.1.21
Alternative name(s):
Histidyl-tRNA synthetase
Short name=HisRS
Gene names
Name:hisS
Ordered Locus Names:SPO0667
OrganismRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi) [Complete proteome] [HAMAP]
Taxonomic identifier246200 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria

Protein attributes

Sequence length495 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). HAMAP-Rule MF_00127

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00127

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00127.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

histidine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 495495Histidine--tRNA ligase HAMAP-Rule MF_00127
PRO_0000136248

Sequences

Sequence LengthMass (Da)Tools
Q5LVN3 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 0BD396AF615967FE

FASTA49553,962
        10         20         30         40         50         60 
MAKPKKTPRP KAETPKGFRD YFGAEVTQRT EMLRDIAGVY HRYGFEALES SAVETVEALG 

        70         80         90        100        110        120 
KFLPDVDRPN EGVFAWQESE DDGAGDWMAL RYDLTAPLAR VYAQHRNDLP TPYRRYAMGP 

       130        140        150        160        170        180 
VWRNEKPGPG RYRQFYQCDA DTVGSASMAA DAEICAMLSD TLETVGIPRG DYVVRVNNRK 

       190        200        210        220        230        240 
VLNGVLETMG LADEGQRDAV LRTIDKFDKV GEDGVRELLG KGRLDASGAF IDGVGLSDDQ 

       250        260        270        280        290        300 
AGPVLAFLTS RGADAATTVA NLRAAVGASQ IGVQGIDELE QIGDLLAAGG YGPDRIVIDP 

       310        320        330        340        350        360 
SVVRGLGYYT GPVYEAELTF EIFDEKGRKR QFGSVSGGGR YDDLVKRFTG QEVPATGVSI 

       370        380        390        400        410        420 
GVDRLLAALR EKGRIRTAER GPVVVTVMDR DRMADYQAMV AELRNAGIRA EVYLGNPKNF 

       430        440        450        460        470        480 
GNQLKYADKR NSPVAVIEGG DERANGVVQI KDLILGAQIA ANATLEEWKE RPSQYEVARA 

       490 
DLVAKVREIL AEQAG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000031 Genomic DNA. Translation: AAV93975.1.
RefSeqYP_165922.1. NC_003911.12.

3D structure databases

ProteinModelPortalQ5LVN3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246200.SPO0667.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV93975; AAV93975; SPO0667.
GeneID3192980.
KEGGsil:SPO0667.
PATRIC23374601. VBIRuePom114501_0674.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0124.
HOGENOMHOG000018071.
KOK01892.
OMANKIKRAC.
OrthoDBEOG6BPDH4.
ProtClustDBPRK00037.

Family and domain databases

Gene3D3.40.50.800. 1 hit.
HAMAPMF_00127. His_tRNA_synth.
InterProIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERPTHR11476. PTHR11476. 1 hit.
PfamPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMSSF52954. SSF52954. 1 hit.
TIGRFAMsTIGR00442. hisS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYH_RUEPO
AccessionPrimary (citable) accession number: Q5LVN3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: February 1, 2005
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries