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Q5LVN0 (DNAE2_SILPO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Error-prone DNA polymerase
EC=2.7.7.7
Gene names
Name:dnaE2
Ordered Locus Names:SPO0670
OrganismSilicibacter pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) [Complete proteome] [HAMAP]
Taxonomic identifier246200 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Ruegeria

Protein attributes

Sequence length1101 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity. HAMAP MF_01902

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902

Subcellular location

Cytoplasm By similarity HAMAP MF_01902.

Sequence similarities

Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
DNA replication
   Cellular componentCytoplasm
   Molecular functionDNA-directed DNA polymerase
Nucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processDNA repair

Inferred from electronic annotation. Source: UniProtKB-KW

DNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3'-5' exonuclease activity

Inferred from electronic annotation. Source: InterPro

DNA binding

Inferred from electronic annotation. Source: InterPro

DNA-directed DNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11011101Error-prone DNA polymerase HAMAP MF_01902
PRO_0000103399

Sequences

Sequence LengthMass (Da)Tools
Q5LVN0 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 5D732922EEE73E1F

FASTA1,101122,743
        10         20         30         40         50         60 
MTYAELCVTT NFTFLTGASH PEEMITRAAE LGLHAIAITD RNSLAGVVRA YAALKELRRE 

        70         80         90        100        110        120 
ADEAIRIRSQ HRIDSCSRQE VGHPQPIARP EAPRLPRLIT GCRLVLRDSP LHWIALPRDR 

       130        140        150        160        170        180 
AAYQRLTRLL TLGKRRAEKG DCHLDLADLL AGCTGMILIA LPQGRLDGAL PHLQQVQRRF 

       190        200        210        220        230        240 
PGHVFLGAAP RYDGSDQAWL AACARLALRS SAPMVAVGDA LMHRANRRQL ADVLTCMREH 

       250        260        270        280        290        300 
ITIDRIGTRA LPNAERRLKG HADMARLFRD HPAALRRTLD IAARCSFCLS ELSYEYPDEV 

       310        320        330        340        350        360 
AEGETPQARL ERLTAEGIVR RYPGGAPQRV HELVAKELKL VAELGFPAYF LTVHDIVQFA 

       370        380        390        400        410        420 
RSQGILCQGR GSAANSILCY LLGITDVSPD QIAMVFERFI SKYRGEPPDI DVDFEHERRE 

       430        440        450        460        470        480 
EVIQWIYQRY GRHRAGLCAT VIHFRSRAAI REVGKVMGLS QDVTASLSGQ IWGQSNGGAD 

       490        500        510        520        530        540 
PERMRELGLD PEDRRLALTI RLIGEIIGFP RHLSQHVGGF VITRGRLDEL APIENAAMED 

       550        560        570        580        590        600 
RTLIEWDKDD IDTLGILKVD VLGLGMLTCI RKAFDLMREH EQRHLSIDTV PQEDAATYDM 

       610        620        630        640        650        660 
LCAADAVGVF QVESRAQMNF LPRMRPRTFY DLVIEVAIVR PGPIQGGMVQ PYIRRRQGLE 

       670        680        690        700        710        720 
KAEPFGPELA AVTARTLGVP LFQEQALQIA VVGAGYTAEE ADHLRRSLAS FRRMGTIGAH 

       730        740        750        760        770        780 
RDTFIAGMRR NGYSQEVAER CFGQIEGFAD YGFPESHAAA FAMLAYVSAW LKCHHPAIFA 

       790        800        810        820        830        840 
CALLNAQPMG FYAPAQIVRD ARDHQVELRP ICVNASDWDN RLERRADGAL ALRLGFRQIK 

       850        860        870        880        890        900 
GFREEDAAWI VAARGNGYPD PQALWLRAGV TPAVLERLAE ADAFADMGIG RRDALWQVRA 

       910        920        930        940        950        960 
IRGQAPLPLF NDPLDGEIIH EPQVTLPAMH LGEEVVEDYV SMRLTLRAHP MELLRPAIPG 

       970        980        990       1000       1010       1020 
LTPHDKLASV AAHRVSVCGL VITRQRPGTA SGVIFLTLED ETGVSNVVVW PKIYEQFRRI 

      1030       1040       1050       1060       1070       1080 
VMGGRLLRVT GTLQREGIVV HLIAQRIEDL SPRLADLGHP MDSAVGQTTP QTDSAPRPRP 

      1090       1100 
QPRAMHPREQ AKRLFPSRDF H

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000031 Genomic DNA. Translation: AAV93978.1.
RefSeqYP_165925.1. NC_003911.11.

3D structure databases

ProteinModelPortalQ5LVN0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3195523.
GenomeReviewsGene locus SPO0670 in contig CP000031_GR.
KEGGsil:SPO0670.
NMPDRfig|246200.3.peg.576.
PATRIC23374607. VBIRuePom114501_0677.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG734490.
OMAADYCANG.
ProtClustDBCLSK933325.

Enzyme and pathway databases

BioCycRPOM246200:SPO_0670-MONOMER.

Family and domain databases

HAMAPMF_01902. DNApol_error_prone.
[Tree]
InterProIPR011708. DNA_pol3_alpha.
IPR023073. DNA_pol_error_prone.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA-helicase.
IPR004013. PHP_C.
IPR003141. Pol/His_phosphatase_N.
IPR016195. Pol/histidinol_Pase-like.
IPR004805. PolC_alpha.
[Graphical view]
Gene3DG3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KOK14162.
PfamPF07733. DNA_pol3_alpha. 1 hit.
PF02811. PHP. 1 hit.
PF01336. tRNA_anti. 1 hit.
[Graphical view]
SMARTSM00481. POLIIIAc. 1 hit.
[Graphical view]
SUPFAMSSF89550. PHP-like. 1 hit.
TIGRFAMsTIGR00594. Polc. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDNAE2_SILPO
AccessionPrimary (citable) accession number: Q5LVN0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: February 1, 2005
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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