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Q5LUS2

- HISX2_RUEPO

UniProt

Q5LUS2 - HISX2_RUEPO

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Protein
Histidinol dehydrogenase 2
Gene
hisD2, SPO0981
Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei119 – 1191NAD By similarity
Binding sitei181 – 1811NAD By similarity
Binding sitei204 – 2041NAD By similarity
Binding sitei227 – 2271Substrate By similarity
Metal bindingi249 – 2491Zinc By similarity
Binding sitei249 – 2491Substrate By similarity
Metal bindingi252 – 2521Zinc By similarity
Binding sitei252 – 2521Substrate By similarity
Active sitei319 – 3191Proton acceptor By similarity
Active sitei320 – 3201Proton acceptor By similarity
Binding sitei320 – 3201Substrate By similarity
Metal bindingi353 – 3531Zinc By similarity
Binding sitei353 – 3531Substrate By similarity
Binding sitei407 – 4071Substrate By similarity
Metal bindingi412 – 4121Zinc By similarity
Binding sitei412 – 4121Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 2 (EC:1.1.1.23)
Short name:
HDH 2
Gene namesi
Name:hisD2
Ordered Locus Names:SPO0981
OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Taxonomic identifieri246200 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
ProteomesiUP000001023: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Histidinol dehydrogenase 2UniRule annotation
PRO_0000135847Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246200.SPO0981.

Structurei

3D structure databases

ProteinModelPortaliQ5LUS2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK15509.
OMAiIFIVADE.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5LUS2-1 [UniParc]FASTAAdd to Basket

« Hide

MTITVLKSAP GLPPAPQGDA ADVVQVMLAR LRAEGEAAAR DYAARLDGWS    50
GEIVVSPDQV ARASEQVPED LKTQIRYAHD NIRRFAEAQR ASALDFQTEL 100
RPGLIAGQKQ IPLAAAGAYV PGGRYAHIAS ALMSIATARA AGVGQITAVS 150
PPQVGRGVHP AILYAMSLAG ADRILALGGV QGVAALAFGL FGAPPADILV 200
GPGNQFVAEA KRQLFGPVGI DMFAGPTDSL VIADSTADPL TVAWDLVGQA 250
EHGYNSPVWL VTDSAALAEA VLAHIPGCIA DLPEPNRSSA QAAWDALGEV 300
ILCTDREEMA ATADRYAPEH LHVQAADLDW WRGRLSAYGS LFLGELTTVA 350
FGDKASGPNH VLPTSGAARY TGGLSVHKFL KTVTWQQVAP QALPDLARAT 400
ATISRAEGME GHARTADIRL EKLRPTLRQV GTG 433
Length:433
Mass (Da):45,353
Last modified:February 1, 2005 - v1
Checksum:iB67DC5531FADA3A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000031 Genomic DNA. Translation: AAV94285.1.
RefSeqiYP_166233.1. NC_003911.12.

Genome annotation databases

EnsemblBacteriaiAAV94285; AAV94285; SPO0981.
GeneIDi3193830.
KEGGisil:SPO0981.
PATRICi23375249. VBIRuePom114501_0996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000031 Genomic DNA. Translation: AAV94285.1 .
RefSeqi YP_166233.1. NC_003911.12.

3D structure databases

ProteinModelPortali Q5LUS2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246200.SPO0981.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV94285 ; AAV94285 ; SPO0981 .
GeneIDi 3193830.
KEGGi sil:SPO0981.
PATRICi 23375249. VBIRuePom114501_0996.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K15509.
OMAi IFIVADE.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700808 / DSM 15171 / DSS-3.

Entry informationi

Entry nameiHISX2_RUEPO
AccessioniPrimary (citable) accession number: Q5LUS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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