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Protein

Histidinol dehydrogenase 2

Gene

hisD2

Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (SPO0669)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2 (hisA2), 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 1 (hisA1)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC), Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase 2 (hisD2), Histidinol dehydrogenase 3 (hisD3), Histidinol dehydrogenase 1 (hisD1)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei119NADUniRule annotation1
Binding sitei181NADUniRule annotation1
Binding sitei204NADUniRule annotation1
Binding sitei227SubstrateUniRule annotation1
Metal bindingi249ZincUniRule annotation1
Binding sitei249SubstrateUniRule annotation1
Metal bindingi252ZincUniRule annotation1
Binding sitei252SubstrateUniRule annotation1
Active sitei319Proton acceptorUniRule annotation1
Active sitei320Proton acceptorUniRule annotation1
Binding sitei320SubstrateUniRule annotation1
Metal bindingi353ZincUniRule annotation1
Binding sitei353SubstrateUniRule annotation1
Binding sitei407SubstrateUniRule annotation1
Metal bindingi412ZincUniRule annotation1
Binding sitei412SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciRPOM246200:G1G48-988-MONOMER
UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 2UniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDH 2UniRule annotation
Gene namesi
Name:hisD2UniRule annotation
Ordered Locus Names:SPO0981
OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Taxonomic identifieri246200 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
Proteomesi
  • UP000001023 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001358471 – 433Histidinol dehydrogenase 2Add BLAST433

Proteomic databases

PRIDEiQ5LUS2

Interactioni

Protein-protein interaction databases

STRINGi246200.SPO0981

Structurei

3D structure databases

ProteinModelPortaliQ5LUS2
SMRiQ5LUS2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEK Bacteria
COG0141 LUCA
HOGENOMiHOG000243914
KOiK15509
OMAiTEGMEGH
OrthoDBiPOG091H03YX

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q5LUS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITVLKSAP GLPPAPQGDA ADVVQVMLAR LRAEGEAAAR DYAARLDGWS
60 70 80 90 100
GEIVVSPDQV ARASEQVPED LKTQIRYAHD NIRRFAEAQR ASALDFQTEL
110 120 130 140 150
RPGLIAGQKQ IPLAAAGAYV PGGRYAHIAS ALMSIATARA AGVGQITAVS
160 170 180 190 200
PPQVGRGVHP AILYAMSLAG ADRILALGGV QGVAALAFGL FGAPPADILV
210 220 230 240 250
GPGNQFVAEA KRQLFGPVGI DMFAGPTDSL VIADSTADPL TVAWDLVGQA
260 270 280 290 300
EHGYNSPVWL VTDSAALAEA VLAHIPGCIA DLPEPNRSSA QAAWDALGEV
310 320 330 340 350
ILCTDREEMA ATADRYAPEH LHVQAADLDW WRGRLSAYGS LFLGELTTVA
360 370 380 390 400
FGDKASGPNH VLPTSGAARY TGGLSVHKFL KTVTWQQVAP QALPDLARAT
410 420 430
ATISRAEGME GHARTADIRL EKLRPTLRQV GTG
Length:433
Mass (Da):45,353
Last modified:February 1, 2005 - v1
Checksum:iB67DC5531FADA3A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000031 Genomic DNA Translation: AAV94285.1
RefSeqiWP_011046729.1, NC_003911.12

Genome annotation databases

EnsemblBacteriaiAAV94285; AAV94285; SPO0981
KEGGisil:SPO0981

Similar proteinsi

Entry informationi

Entry nameiHISX2_RUEPO
AccessioniPrimary (citable) accession number: Q5LUS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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