Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histidinol dehydrogenase 2

Gene

hisD2

Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei119 – 1191NADUniRule annotation
Binding sitei181 – 1811NADUniRule annotation
Binding sitei204 – 2041NADUniRule annotation
Binding sitei227 – 2271SubstrateUniRule annotation
Metal bindingi249 – 2491ZincUniRule annotation
Binding sitei249 – 2491SubstrateUniRule annotation
Metal bindingi252 – 2521ZincUniRule annotation
Binding sitei252 – 2521SubstrateUniRule annotation
Active sitei319 – 3191Proton acceptorUniRule annotation
Active sitei320 – 3201Proton acceptorUniRule annotation
Binding sitei320 – 3201SubstrateUniRule annotation
Metal bindingi353 – 3531ZincUniRule annotation
Binding sitei353 – 3531SubstrateUniRule annotation
Binding sitei407 – 4071SubstrateUniRule annotation
Metal bindingi412 – 4121ZincUniRule annotation
Binding sitei412 – 4121SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 2UniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDH 2UniRule annotation
Gene namesi
Name:hisD2UniRule annotation
Ordered Locus Names:SPO0981
OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Taxonomic identifieri246200 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
ProteomesiUP000001023: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Histidinol dehydrogenase 2PRO_0000135847Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246200.SPO0981.

Structurei

3D structure databases

ProteinModelPortaliQ5LUS2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK15509.
OMAiIFIVADE.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5LUS2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTITVLKSAP GLPPAPQGDA ADVVQVMLAR LRAEGEAAAR DYAARLDGWS
60 70 80 90 100
GEIVVSPDQV ARASEQVPED LKTQIRYAHD NIRRFAEAQR ASALDFQTEL
110 120 130 140 150
RPGLIAGQKQ IPLAAAGAYV PGGRYAHIAS ALMSIATARA AGVGQITAVS
160 170 180 190 200
PPQVGRGVHP AILYAMSLAG ADRILALGGV QGVAALAFGL FGAPPADILV
210 220 230 240 250
GPGNQFVAEA KRQLFGPVGI DMFAGPTDSL VIADSTADPL TVAWDLVGQA
260 270 280 290 300
EHGYNSPVWL VTDSAALAEA VLAHIPGCIA DLPEPNRSSA QAAWDALGEV
310 320 330 340 350
ILCTDREEMA ATADRYAPEH LHVQAADLDW WRGRLSAYGS LFLGELTTVA
360 370 380 390 400
FGDKASGPNH VLPTSGAARY TGGLSVHKFL KTVTWQQVAP QALPDLARAT
410 420 430
ATISRAEGME GHARTADIRL EKLRPTLRQV GTG
Length:433
Mass (Da):45,353
Last modified:February 1, 2005 - v1
Checksum:iB67DC5531FADA3A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000031 Genomic DNA. Translation: AAV94285.1.
RefSeqiYP_166233.1. NC_003911.12.

Genome annotation databases

EnsemblBacteriaiAAV94285; AAV94285; SPO0981.
GeneIDi3193830.
KEGGisil:SPO0981.
PATRICi23375249. VBIRuePom114501_0996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000031 Genomic DNA. Translation: AAV94285.1.
RefSeqiYP_166233.1. NC_003911.12.

3D structure databases

ProteinModelPortaliQ5LUS2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246200.SPO0981.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV94285; AAV94285; SPO0981.
GeneIDi3193830.
KEGGisil:SPO0981.
PATRICi23375249. VBIRuePom114501_0996.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK15509.
OMAiIFIVADE.
OrthoDBiEOG6CVVCR.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700808 / DSM 15171 / DSS-3.

Entry informationi

Entry nameiHISX2_RUEPO
AccessioniPrimary (citable) accession number: Q5LUS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: February 1, 2005
Last modified: February 4, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.